Publications by authors named "Scott Conary"
J Biomol Screen
June 2003
Article Synopsis
- Dxr is a crucial enzyme in the isoprenoid biosynthesis pathway unique to bacteria and plants, converting 1-deoxy-D-xylulose 5-phosphate into 2-C-methyl-D-erythritol 4-phosphate.
- Researchers purified Dxr from Escherichia coli and created a high-throughput screening method to find compounds that bind to its functional site, improving the detection of binding interactions compared to traditional assays.
- After screening 32,000 compounds, they identified 89 potent inhibitors, suggesting that peptide surrogates can enhance high-throughput screenings for challenging proteins or those with unknown functions.
