Publications by authors named "Scott Carey"

Empowering the Participant Voice (EPV) is an NCATS-funded six-CTSA collaboration to develop, demonstrate, and disseminate a low-cost infrastructure for collecting timely feedback from research participants, fostering trust, and providing data for improving clinical translational research. EPV leverages the validated Research Participant Perception Survey (RPPS) and the popular REDCap electronic data-capture platform. This report describes the development of infrastructure designed to overcome identified institutional barriers to routinely collecting participant feedback using RPPS and demonstration use cases.

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Objective: To determine if maternal cardiac disease affects delivery mode and to investigate maternal morbidity.

Study Design: Retrospective cohort study performed using electronic medical record data. Primary outcome was mode of delivery; secondary outcomes included indication for cesarean delivery, and rates of severe maternal morbidity.

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Background: The Coronavirus Disease 2019 (COVID-19) pandemic has had substantial global morbidity and mortality. Clinical research related to prevention, diagnosis, and treatment of COVID-19 is a top priority. Effective and efficient recruitment is challenging even without added constraints of a global pandemic.

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Article Synopsis
  • The study focused on the prevalence of hyperthermia (high body temperature) in children who experience cardiac arrest in hospitals within the first 24 hours after resuscitation.
  • About 43.5% of the 547 pediatric patients showed temperatures of 38°C or higher, with 5.5% experiencing persistent hyperthermia (sustained high temperatures), which later correlated with worse neurological outcomes.
  • Although persistent hyperthermia was linked to unfavorable neurological results, it did not show a significant relationship with the likelihood of death before hospital discharge.
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Objective: We hypothesized that childhood obesity would be associated with decreased likelihood of survival to hospital discharge after in-hospital, pediatric cardiopulmonary resuscitation (CPR).

Methods: We reviewed 1477 consecutive, pediatric, CPR index events (defined as the first CPR event during a hospitalization in that facility for a patient <18 years of age) reported to the American Heart Association National Registry of Cardiopulmonary Resuscitation between January 2000 and July 2004. The primary outcome was survival to hospital discharge.

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Article Synopsis
  • The study investigates how the timing of invasive airway placement (TTIA) affects outcomes in adults after in-hospital cardiac arrest.
  • Researchers analyzed data from over 25,000 cases, focusing on various outcomes like return of spontaneous circulation (ROSC) and survival rates.
  • Findings indicated that while early TTIA did not significantly improve ROSC, it was linked to better odds of survival 24 hours post-arrest, but no conclusions could be drawn regarding survival to hospital discharge.
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Article Synopsis
  • The study examines survival rates for in-hospital cardiac arrest occurrences, comparing outcomes based on time of day (day/evening vs. night) and weekdays vs. weekends using data from over 86,000 cases.* -
  • Key findings indicate lower survival rates during night hours and weekends, with percentages for survival to discharge at 14.7% during nights versus 19.8% during days/evenings, and other critical survival metrics also showing similar patterns.* -
  • The research highlights a potential impact of hospital staffing and resource availability on patient outcomes during off-peak times, suggesting the need for improved care strategies during these periods.*
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Background: Ventricular fibrillation and ventricular tachycardia are less common causes of cardiac arrest in children than in adults. These tachyarrhythmias can also begin during cardiopulmonary resuscitation (CPR), presumably as reperfusion arrhythmias. We determined whether the outcome is better for initial than for subsequent ventricular fibrillation or tachycardia.

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Article Synopsis
  • Cardiac arrests in adults often involve ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT), leading to better survival rates compared to asystole or pulseless electrical activity (PEA), while in children, cardiac arrests are usually asystole or PEA.
  • A study of over 36,000 adults and 880 children across 253 hospitals found that children had a higher survival rate to hospital discharge (27%) compared to adults (18%) following pulseless cardiac arrest.
  • Children had lower rates of VF or pulseless VT (14% vs. 23% in adults), and higher rates of asystole (40% vs. 35% in adults);
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