The Theoretical and Methodological Opportunities Afforded by Guided Play With Young Children.

For infants and young children, learning takes place all the time and everywhere. How children learn best both in and out of school has been a long-standing topic of debate in education, cognitive development, and cognitive science. Recently, has been proposed as an integrative approach for thinking about learning as a child-led, adult-assisted playful activity.

Replication timing is regulated by the number of MCMs loaded at origins.

Replication timing is a crucial aspect of genome regulation that is strongly correlated with chromatin structure, gene expression, DNA repair, and genome evolution. Replication timing is determined by the timing of replication origin firing, which involves activation of MCM helicase complexes loaded at replication origins. Nonetheless, how the timing of such origin firing is regulated remains mysterious.