Can bone morphogenetic protein binding peptide increase efficiency of bone formation?

Study Design: The role of bone morphogenetic protein binding peptide (BBP) in bone formation is reviewed from basic science studies and potential clinical application.

Objective: We review the discovery and early scientific studies of BBP with emphasis on potential future clinical applications.

Summary Of Background Data: Biologics delivered locally to enhance bone formation are of increasing importance, particularly in spinal fusion.

Surgical treatment of early wound complications following primary total knee arthroplasty.

Background: Wound-healing problems are a known complication after primary total knee arthroplasty. However, little is known about the clinical outcomes for patients who require surgical treatment of these early wound-healing problems. The purpose of the present study was to determine the incidence, risk factors, and long-term sequelae of early wound complications requiring surgical treatment.

Early return to surgery for evacuation of a postoperative hematoma after primary total knee arthroplasty.

Background: Development of a postoperative hematoma is a reported complication after primary total knee arthroplasty. However, little is known about the clinical outcomes in patients who require surgical evacuation of an acute hematoma. The purpose of this study was to determine the incidence, risk factors, and long-term sequelae of postoperative hematomas requiring surgical evacuation.

Reactivation of Hox gene expression during bone regeneration.

Previous studies have explored the link between bone regeneration and skeletogenesis. Although a great deal is known regarding tissue and cell based events, especially those involving ossification and chondrogenesis, much remains unknown about the molecular similarity of repair and development. Since the functional significance of Homeobox (Hox) genes in embryonic skeletogenesis has been well documented through knockout and deficiency studies, we chose to investigate whether members of this family are reactivated during fracture repair.