Publications by authors named "Scott C Lowe"
Article Synopsis
- In vivo calcium imaging is a popular technique for visualizing neuron activity, generating extensive image data that requires complex analysis methods.
- The FISSA toolbox (Fast Image Signal Separation Analysis) is introduced to improve the analysis process by effectively removing contamination from surrounding neuropil during fluorescence signal extraction.
- FISSA is efficient, requiring minimal RAM for processing large datasets, and is user-friendly as it can be integrated into existing workflows with options for Python and MATLAB outputs, available on Github.
Neural oscillations are ubiquitously observed in cortical activity, and are widely believed to be crucial for mediating transmission of information across the cortex. Yet, the neural phenomena contributing to each oscillation band, and their effect on information coding and transmission, are largely unknown. Here, we investigated whether individual frequency bands specifically reflect changes in the concentrations of dopamine, an important neuromodulator, and how dopamine affects oscillatory information processing.
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- Cortical responses to sensory stimuli, particularly in the primary visual cortex (V1), are influenced by the animal's state of locomotion, with pyramidal neurons showing increased visual activity during movement.
- The study used in vivo two-photon calcium imaging to examine different types of interneurons (VIP, SST, and PV) in mouse V1 and found that all showed varying levels of activity during locomotion, contradicting the idea that disinhibition solely controls sensory response gain.
- Results indicated that the responsiveness of these interneurons to locomotion depends on the context, with somatostatin (SST) neurons exhibiting the most distinct variations, suggesting a more complex modulation of neuronal activity than previously thought.
Distributed neural processing likely entails the capability of networks to reconfigure dynamically the directionality and strength of their functional connections. Yet, the neural mechanisms that may allow such dynamic routing of the information flow are not yet fully understood. We investigated the role of gamma band (50-80 Hz) oscillations in transient modulations of communication among neural populations by using measures of direction-specific causal information transfer.
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