Publications by authors named "Scott B Millar"
Article Synopsis
- Next-generation antimalarials need to be able to cure malaria and block its transmission, highlighting the importance of discovering new druggable molecular pathways.
- Researchers identified CLK3 as a promising drug target, using a selective inhibitor that affected multiple life stages of the malaria parasite and validated its role through chemogenetics.
- Inhibiting CLK3 led to the down-regulation of over 400 key parasite genes, resulting in rapid killing of the parasite and prevention of gametocyte development, suggesting potential for both curing and preventing malaria transmission.
Plasmodium knowlesi is a newly described zoonosis that causes malaria in the human population that can be severe and fatal. The study of P. knowlesi parasites from human clinical isolates is relatively new and, in order to obtain maximum information from patient sample collections, we explored the possibility of generating P.
View Article and Find Full Text PDFEmerging pathogens undermine initiatives to control the global health impact of infectious diseases. Zoonotic malaria is no exception. Plasmodium knowlesi, a malaria parasite of Southeast Asian macaques, has entered the human population.
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