Probing the nature of black holes: Deep in the mHz gravitational-wave sky.

Black holes are unique among astrophysical sources: they are the simplest macroscopic objects in the Universe, and they are extraordinary in terms of their ability to convert energy into electromagnetic and gravitational radiation. Our capacity to probe their nature is limited by the sensitivity of our detectors. The LIGO/Virgo interferometers are the gravitational-wave equivalent of Galileo's telescope.

Rapid Generation of Fully Relativistic Extreme-Mass-Ratio-Inspiral Waveform Templates for LISA Data Analysis.

The future space mission LISA will observe a wealth of gravitational-wave sources at millihertz frequencies. Of these, the extreme-mass-ratio inspirals of compact objects into massive black holes are the only sources that combine the challenges of strong-field complexity with that of long-lived signals. Such signals are found and characterized by comparing them against a large number of accurate waveform templates during data analysis, but the rapid generation of templates is hindered by computing the ∼10^{3}-10^{5} harmonic modes in a fully relativistic waveform.

Learning about Black Hole Binaries from their Ringdown Spectra.

The coalescence of two black holes generates gravitational waves that carry detailed information about the properties of those black holes and their binary configuration. The final coalescence cycles are in the form of a ringdown: a superposition of quasinormal modes of the merged remnant black hole. Each mode has an oscillation frequency and decay time that in general relativity is determined by the remnant's mass and spin.

Tidal Resonance in Extreme Mass-Ratio Inspirals.

We describe a new class of resonances for extreme mass-ratio inspirals (EMRIs): tidal resonances, induced by the tidal field of nearby stars or stellar-mass black holes. A tidal resonance can be viewed as a general relativistic extension of the Kozai-Lidov resonances in Newtonian systems and is distinct from the transient resonance already known for EMRI systems. Tidal resonances will generically occur for EMRIs.

Modeling extreme mass ratio inspirals within the effective-one-body approach.

We present the first models of extreme-mass-ratio inspirals within the effective-one-body (EOB) formalism, focusing on quasicircular orbits into nonrotating black holes. We show that the phase difference and (Newtonian-normalized) amplitude difference between analytical EOB and numerical Teukolsky-based gravitational waveforms can be reduced to less than or approximately 10{-1} rad and less than or approximately 2x10{-3}, respectively, after a 2-year evolution. The inclusion of post-Newtonian self-force terms in the EOB approach leads to a phase disagreement of approximately 6-27 rad after a 2-year evolution.

Gravitational radiation reaction and inspiral waveforms in the adiabatic limit.

We describe progress evolving an important limit of binaries in general relativity: stellar mass compact objects spiraling into much larger black holes. Such systems are of great observational interest. We have developed tools to compute for the first time the radiation from generic orbits.

Transgenic mouse model for echovirus myocarditis and paralysis.

Echoviruses have been implicated in multiple human disease syndromes, including aseptic meningitis, paralysis, and heart disease, but no animal model is available for studying the pathogenesis of infection. Production of human integrin very late antigen 2, a receptor for echovirus type 1, in transgenic mice conferred susceptibility to viral infection. Intracerebral inoculation of newborn transgenic mice with echovirus leads to paralysis and wasting.