The bactericidal effect of vancomycin is not altered by tranexamic acid, adrenalin, dexamethasone, or lidocaine in vitro.

One of the most challenging complications of total knee arthroplasty (TKA) is periprosthetic joint infection (PJI). There is growing evidence of a good anti-infective effect of intrawound vancomycin powder in total joint arthroplasty. At the same time, various different locally applied substances have become popular in total joint arthroplasty.

Effect of additional distal femoral resection on flexion deformity in posterior-stabilized total knee arthroplasty.

Purpose: Flexion deformity after total knee arthroplasty (TKA) is associated with poor function and dissatisfaction and should, therefore, be avoided. In the case of preoperative flexion deformity, an increased distal resection of the femur may be necessary. The degree of resection required has only been determined for cruciate-retaining (CR) prostheses to date and varies considerably from study to study.

Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.

Dysregulated intestinal epithelial apoptosis initiates gut injury, alters the intestinal barrier, and can facilitate bacterial translocation leading to a systemic inflammatory response syndrome (SIRS) and/or multi-organ dysfunction syndrome (MODS). A variety of gastrointestinal disorders, including inflammatory bowel disease, have been linked to intestinal apoptosis. Similarly, intestinal hyperpermeability and gut failure occur in critically ill patients, putting the gut at the center of SIRS pathology.

Local Anesthetics' Toxicity toward Human Cultured Chondrocytes: A Comparative Study between Lidocaine, Bupivacaine, and Ropivacaine.

Objective: In orthopedic joint injection, the most frequently used local anesthetics are ropivacaine, bupivacaine, and 1% or 2% lidocaine. The aim of this study was to examine effects of these various anesthetics on the viability of human chondrocytes. Our hypothesis was that all local anesthetics tested damage human chondrocytes .

Right-heart failure after right heart catheterization in a patient with scleroderma and suspected pulmonary hypertension.

The case presented here describes the fatal outcome of a right heart catheterization of a female patient with scleroderma. At autopsy, a massive fibrosis of the cardial muscle, the atrioventricular, and the sinoatrial node was described. Patients with scleroderma are prone to cardiac involvement and have an increased risk of sudden cardiac death.

[The clinical picture of the chronic pain patient-Analysis of a pain outpatient clinic using headache as an example.].

Introduction: Patients with chronic headache are seen in an interdisciplinary pain clinic after many years of treatment. Compared with other pain syndromes, the standards for diagnosis and treatment are widely accepted according to the guidelines of the International Headache Society. Nevertheless, many patients continue to suffer.

Effect of ascorbic acid on rhinovirus replication in WI-38 cells.

Exposure of WI-38 cells to ascorbic acid plus glutathione mixtures in growth medium for 2 days prior to infection with rhinovirus serotype 20 and during virus replication suppressed multicyclic but not single-cycle growth of the virus. Multicyclic growth was suppressed over the range of multiplicity of infection (m.o.

Shope fibroma virus growth curve in suspended tissue culture.

As a tumour-producing agent, Shope's rabbit fibroma virus (a member of the myxoma-fibroma subgroup of the poxviruses) is endowed with potentialities which differ from those of vaccinia virus. This work attemps to find, by the technique of the one-step growth curve in suspended cells, if the virus replication scheme is similar to other poxviruses. Fibroma virus seems to multiply rather slowly and to a limited level, but the pattern is characteristic of the poxviruses: eclipse phase, exponential multiplication, reduced release of virus in the medium are the main features.

The intracellular distribution of Lansing poliomyelitis virus in the central nervous system of infected cotton rats.

A procedure has been described for the centrifugal fractionation of the cellular particulate components of CNS tissue infected with poliomyelitis virus. A study of the distribution of infectivity among these components revealed that approximately four-fifths of the virus is found free in the submicroscopic particle fraction. The validity of the conclusion that the virus is located in this fraction of the intact neuron is discussed.