[Comparative elimination of pirprofen from the plasma and synovial fluid of the knee. 26 cases].

Twenty-six patients with various inflammatory diseases of the knee were treated with a 400 mg dose of pirprofen orally twice a day for 2 days. On the third day, samples of blood and synovial fluid were taken 3 h and 10 h approximately after a fifth 400 mg dose of the drug. Pirprofen concentrations, as determined by gas-liquid chromatography, were higher in plasma than in synovial fluid during the 2-5 h period post-dosing.

[Anti-perinuclear antibodies in the diagnosis and prognosis of rheumatoid polyarthritis].

Anti-perinuclear antibodies (APN) were studied in 547 subjects, 123 of whom suffered from rheumatoid polyarthritis (RP). They were detected 88 times in the latter group (72 percent). 26 percent of RP were without serological abnormalities when only rheumatoid factors were considered (latex, Waaler-Rose, Waaler-Rose LOR, rheumatoid factors by indirect immunofluorescence).

[Muscular involvement in adult Still's disease. Apropos of 5 new cases].

Still disease was first described in adults ten years ago. Muscular involvement was already mentioned in the first reports. However, it's incidence is underestimated as it is often mistaken for arthralgia.

[Still disease in adults].

In 1971, less than one-hundred years after Still's publication (1897) concerning children, Bywaters described the adult-onset form of Still disease. Over one-hundred cases of this disorder have been recorded since. In adults, Still disease affects mainly women, and the average age at onset is twenty-seven.

[The neuro-ophthalmological complications in SLE (author's transl)].

In a 44 years old woman, a flare up of polyarthritis becoming positive for sero-reaction at the time of hospitalization, is referred to an earlier unknown SLE. The bilateral optic neuritis which began 15 years earlier, while she was pregnant, simultaneously with a bilateral carpal tunnel syndrome is retrospectively related to the SLE. Such an optic neuritis is rare, its clinical features are specified among the neuro-ophthalmological complications in SLE.