Non-neoplastic and neoplastic scrotal pathologies on magnetic resonance imaging: a pictorial essay.

Magnetic resonance imaging is an essential tool for the assessment of the scrotum, particularly in cases with inconclusive ultrasound findings. It has a great capacity to differentiate between intratesticular and extratesticular lesions, as well as between neoplastic and non-neoplastic lesions. By providing an accurate characterization of lesions, magnetic resonance imaging plays a crucial role in preoperative tumor staging and decision-making.

Cocoa ( L.) photobiological effect on human fibroblast cells (HFF-1) exposed to ultraviolet B (UVB) radiation.

This study aimed to investigate the photobiological action of cocoa solution on a human fibroblast cell line (HFF-1) exposed to ultraviolet B (UVB) radiation. Three experimental models were utilized, where fibroblast cells were treated with different concentrations of cocoa as follows: 50; 100; 250; 500; 750; 1000 or 1500 µg/ml and concomitantly exposed to UVB 7 kJ/m for 10 min. The following parameters were examined 1) analysis of the pre-treatment action of cocoa; 2) investigation of the co-treatment activity of cocoa at the time of exposure; and 3) study the effect of cocoa in the post-treatment of the damage initiated by UVB.

Treatment adherence and effectiveness in patients treated with carfilzomib-based therapy combinations for relapsed/refractory multiple myeloma in Germany: interim results from the non-interventional CARO study.

Therapy adherence can significantly influence the outcome of cancer patients. The prospective, non-interventional CARO study (NCT02970747) investigated adherence, effectiveness, and safety of carfilzomib in patients with relapsed/refractory multiple myeloma (RRMM) in the German real-world setting. In total, 359 patients were included at 69 sites.

Light exposure of tetra-cationic porphyrins containing peripheral Pd(II)-bipyridyl complexes and the induced effects on purified DNA molecule, fibroblast and melanoma cell lines.

Photodynamic therapy (PDT) combines a light source, oxygen, and a photosensitizer (PS) to generate reactive oxygen species (ROS) for treating diseases. In this study, we evaluated two meso-tetra-pyridyl porphyrins with [Pd(bpy)Cl], namely 3-PdTPyP and 4-PdTPyP, as PS for PDT application. DNA interaction was assessed by spectroscopic measurements (UV-Vis and fluorescence emission), viscosity analysis, and molecular docking simulations.

Color Biomimetics in Textile Design: Reproduction of Natural Plant Colors through Instrumental Colorant Formulation.

This paper explores the intersection of colorimetry and biomimetics in textile design, focusing on mimicking natural plant colors in dyed textiles via instrumental colorant formulation. The experimental work was conducted with two polyester substrates dyed with disperse dyes using the exhaustion process. Textiles dyed with different dye colors and concentrations were measured in a spectrophotometer and a database was created in Datacolor Match Textile software version 2.

Limited contribution of photoenzymatic DNA repair in mitigating carry-over effects from larval UVB exposure: Implications for frog recruitment.

Solar ultraviolet-B (UVB) radiation has increased due to stratospheric ozone depletion, climate and ecosystem changes and is a driver of amphibian population declines. Photoenzymatic repair (PER) is a critical mechanism for limiting UVB lethality in amphibian larvae. However, the link between PER and the UVB-induced effects remains understudied through long-term investigations in vivo.

Practical Guide to VI-RADS: MRI Protocols, Lesion Characterization, and Pitfalls.

Urothelial carcinoma is the most common type of bladder cancer (BC), accounting for approximately 90% of all cases. Evaluating the depth of tumor invasion in the bladder wall (tumor staging) is essential for determining the treatment and prognosis in patients with BC. Neoadjuvant therapy followed by radical cystectomy is the most common treatment of localized muscle-invasive BC (MIBC).

The Brazilian national prospective active surveillance (AS) cohort of patients with low-risk prostate cancer in the public health system: vigiaSUS study protocol.

Background: Prostate cancer exhibits a very diverse behaviour, with some patients dying from the disease and others never needing treatment. Active surveillance (AS) consists of periodic PSA assessment (prostate-specific antigen), DRE (digital rectal examination) and periodic prostate biopsies. According to the main guidelines, AS is the preferred strategy for low-risk patients, to avoid or delay definitive treatment.

[Utilization of video consultation in cardiovascular lipid treatment].

Background: Video consultation is a possibility for physician-patient communication independent of the location; however, only limited information is available for the possibility of sole use since 2018.

Methods: After the implementation of video consultation (Viomedi) in lipid consultations at the Medical University Mainz, the patients in the first quarter of 2022 were assessed depending on the possibility, suitability and readiness to participate. Included were patients under lipid management and long COVID patients.

DNA-Interactive and Damage Study with -Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes.

We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (, and ). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule.

Heart rate variability: reference values and role for clinical profile and mortality in individuals with heart failure.

Aims: To establish reference values and clinically relevant determinants for measures of heart rate variability (HRV) and to assess their relevance for clinical outcome prediction in individuals with heart failure.

Methods: Data from the MyoVasc study (NCT04064450; N = 3289), a prospective cohort on chronic heart failure with a highly standardized, 5 h examination, and Holter ECG recording were investigated. HRV markers were selected using a systematic literature screen and a data-driven approach.

Genotoxicity of surface waters in Brazil.

Brazil has abundant surface water resources, huge aquatic biodiversity and is home to 213 million people. Genotoxicity assays are sensitive tools to detect the effects of contaminants in surface waters and wastewaters, as well as to determine potential risks of contaminated waters to aquatic organisms and human health. This work aimed to survey the articles published in 2000-2021 that evaluated the genotoxicity of surface waters within Brazilian territory to unveil the profile and trends of this topic over time.

Toxicological and behavioral analyses indicates the safety of a biofertilizer in the non-target D. melanogaster.

The demand for food to feed the growing world population has been promoting the indiscriminate use of chemical fertilizers, which can be detrimental to the environment. In order to maintain high crop productivity without damaging the ecosystem, biofertilizers have emerged as alternative to reduce the use of chemical fertilizers. So, environmentally safer biofertilizer can replace the exploitation of more toxic chemical fertilizer.

Effects of isolated and combined exposures of Boana curupi (Anura: Hylidae) tadpoles to environmental doses of trichlorfon and ultraviolet radiation.

The biodiversity collapse strongly affects the amphibian group and many factors have been pointed out as catalytic agents. It is estimated that several events in the amphibian population decline worldwide may have been caused by the interaction of multiple drivers. Thus, this study aimed to evaluate the stressful effects of the exposure to environmental doses of trichlorfon (TCF) pesticide (0.

New FIB-4 and NFS cutoffs to guide sequential non-invasive assessment of liver fibrosis by magnetic resonance elastography in NAFLD.

Introduction And Objectives: Liver fibrosis is an important prognosis marker in non-alcoholic fatty liver disease (NAFLD). Biopsy has been considered the gold-standard method for measuring liver fibrosis; however, it is an invasive procedure. Non-invasive diagnostic tools have been developed, such as clinical scores and magnetic resonance elastography (MRE), which is the most accurate non-invasive method to determine liver fibrosis.

Magnetic resonance imaging findings in placenta accreta spectrum disorders: pictorial essay.

Placenta accreta spectrum disorders are characterized by abnormal adhesion of the placenta that can be subdivided into three categories according to degree of invasion: placenta accreta (passing through the decidua basalis and adhering to the myometrium); placenta increta (penetrating the myometrium); and placenta percreta (invading the uterine serosa or adjacent tissues or organs). The incidence of placenta accreta has increased significantly in recent decades, mainly because of an increase in the rates of cesarean section, which is its main risk factor. Accurate prenatal identification makes it possible to institute the ideal treatment with a multidisciplinary team, significantly minimizing maternal morbidity and mortality.

FEV Predicts Cardiac Status and Outcome in Chronic Heart Failure.

Background: COPD is an established predictor of clinical outcome in patients with chronic heart failure (HF). However, little evidence is available about the predictive value of FEV in chronic HF.

Research Question: Is pulmonary function related to the progression of chronic HF?

Study Design And Methods: The MyoVasc study (ClinicalTrials.

Imaging findings of melanoma metastasis in the gallbladder.

We present the case of a 40-year-old male with a previous diagnosis of cutaneous melanoma in the dorsal region, with metastases in axillary and mesenteric lymph nodes and in the central nervous system. He presented focal areas of increased radiopharmaceutical uptake in the topography of the gallbladder infundibulum on a control positron emission tomography/computed tomography (PET/CT), which corresponded to a nodular lesion in an abdominal ultrasound.

Adaptive Subsets Limit the Anti-Tumoral NK-Cell Activity in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a global health burden with increasing incidence, poor prognosis and limited therapeutic options. Natural killer (NK) cells exhibit potent anti-tumoral activity and therefore represent potential targets for immunotherapeutic approaches in HCC treatment. However, the anti-tumoral activity of NK cells in HCC associated with different etiologies, and the impact of the heterogeneous NK cell subset, e.