Improved survival in variceal hemorrhage with emergent sclerotherapy.

Over a 2-yr period (1984-1985) we performed emergent endoscopic injection sclerotherapy (EIS) within 12 h in 25 consecutive episodes of variceal hemorrhage (VH). The outcome was compared to the preemergent period (1982-1984) when 22 episodes of VH were treated first with vasopressin and balloon tamponade, and then by EIS, in cases which failed to resolve. In those with decompensated liver disease, average transfusions dropped from 12.

Talc liver.

Talc in the liver is highly suggestive of intravenous drug abuse. We report three patients in whom finding talc or talc granuloma on liver biopsy led to the diagnosis of unsuspected i.v.

Phenytoin hypersensitivity hepatitis and mononucleosis syndrome.

We present a patient who developed a mononucleosis syndrome 6 weeks after starting phenytoin therapy for a seizure disorder. Improvement followed initial discontinuation of the phenytoin, but near-fatal hepatic necrosis resulted from intravenous phenytoin rechallenge. A serious reaction with a 18% overall mortality, phenytoin hepatitis may closely resemble infectious mononucleosis with fever, pharyngitis, lymphadenopathy, and atypical lymphocytosis.

Gastric cancer in a young adult.

We report a case of gastric adenocarcinoma in a 23-yr-old white man. Since only 1% of gastric cancers occur in patients under 35 yr or age, the diagnosis is often overlooked. The presence of persistent pain, weight loss, early satiety, anemia, and vomiting are clues to the underlying disorder.

Hepatobiliary system in sickle cell disease.

This paper reviews the literature reports concerning sickle cell disease and the hepatobiliary system. Sickle cell disease can cause progressive injury to the liver with significant fibrosis, often cirrhosis, and decreased liver function by adulthood. Asymptomatic patients commonly have hepatomegaly and elevated liver enzyme levels.

[Results of fluorescence microscopy studies of bone healing by direct stimulation with bipolar impulse currents and with the interference current procedure in the animal experiment].

42 cross-breed rabbit bastards of either sex were osteotomized on the left proximal third of the tibia. A teflonisolated stable plating was made by means of the polychromatically KF-AO-instrumentarium. The animals were fluorescentlabelled in weekly intervals.

Salicylate-induced seizures in a dog.

A 10-year-old, mixed-breed, castrated male dog was examined because of acute onset of vomiting followed by severe generalized seizures. The dog had been on a treatment regimen that included a salicylate-containing drug, and the owners unknowingly supplemented aspirin. Supportive treatment utilizing sodium bicarbonate resulted in return to normal within 24 hours.

Acute renal failure secondary to myoglobinuria associated with Legionnaires' disease.

A case of nonfatal Legionnaires' disease was complicated by rhabdomyolysis, myoglobinuria, and acute nonoliguric renal failure. It was not determined whether the rhabdomyolysis was secondary to direct toxic effect of the organism or due to a circulating factor causing muscle necrosis. This case provides additional evidence that rhabdomyolysis with subsequent renal failure may be a serious complication of Legionnaires' disease.

[Rate of maturation of osteons].

This paper examines the dynamics of Havers'ian remodelling and the concept of maturation rate of poly-chrome fluorescence-labeling osteons by means measurements of bone formation. It was used cortical bone of rabbit and merino sheep on various experimental conditions (Normal bone growth in the diaphysis of large bone and cortical bone of iliac crest, secondary fracture healing in tibia osteosyntheses with external fixation and oligotrophic pseudoarthrosis in rabbit. Gap healing of fractures in tibia osteosyntheses with external fixation and compression in the sheep).

The role of endoneurial fibroblasts in myelin degradation.

Counts of nuclei in electron micrographs of rat sciatic nerve show that approximately one third of the nuclear population is fibroblasts. Comparison of these figures with counts in teased fibers indicates that the majority of fibroblasts adheres tightly to myelinated nerve fibers. The early reactions and cellular transformations of the endoneurial fibroblast population upon intraneurial injections of india ink or of a purified preparation of rat sciatic myelin were studied for intervals of from 6 hours to 3 days after injection.

Phycomycosis of the gastrointestinal tract.

A case of gastrointestinal phycomycosis, a highly lethal fungal infection, is presented. Radiographic, operative and histopathologic features are discussed. Pathogenesis of the disease and the importance of underlying illness, malnutrition, immunosuppression and antibiotic therapy are considered.

Hemoperitoneum from a ruptured varix in cirrhosis. Case report and literature review.

A cirrhotic patient with hemoperitoneum is presented. The diagnosis of ruptured retroperitoneal varices was made at laparotomy and the patient becomes the second reported case to survive hospitalization for bleeding intra-abdominal varices. The formation of varices as a consequence of portal hypertension is discussed; the differential diagnosis and evaluation of hemoperitoneum is considered and the seven previously reported cases of intra-abdominal variceal hemorrhage are reviewed.

Palatability studies of snail and slug poison baits, using dogs.

In 1975, the California Department of Food and Agriculture required registered manufacturers of snail and slug baits to present data showing the unattractiveness of these products to dogs, in order to reduce the number deaths in dogs due to poisoning by eating these baits. A cooperative project involving the University of California, the California Department of Food and Agriculture, and the snail and slug bait manufacturers was designed to assist the manufacturers in assessing the palatability of their products by dogs and to develop criteria for the regulatory agencies to use to ensure that the products they were registering were unattractive to dogs. The studies showed that most recently formulated baits were relatively unpalatable for dogs.