Occupational adjustments and work ability of young adult cancer survivors: results from the AYA-Leipzig study.

Purpose: Adolescent and young adult cancer survivors (AYA-CS) face a long working life after treatment, yet factors related to a successful return to work remain largely unexplored. We therefore aimed to investigate the use of occupational adjustments and their impact on work ability upon return to work.

Methods: As part of the AYA-LE study, we surveyed AYA-CS (aged 18-39 at diagnosis) who returned to work and assessed work ability (Work Ability Index) as well as use and benefit of occupational adjustments.

The utility of using Volunteered Geographic Information (VGI) for evaluating pluvial flood models.

Pluvial floods are increasingly threatening urban environments worldwide due to human-induced climate change. High-resolution, state-of-the-art pluvial flood models are urgently needed to inform climate change adaptation and disaster risk reduction measures but are generally not empirically tested because of the rarity of local high-intensity precipitation events and the lack of monitoring capabilities. Volunteered Geographic Information (VGI) collected by professionals, non-professionals and citizens and made available on the internet can be used to monitor the dynamic extent of a pluvial flood during and after an extreme rain event but is sometimes considered to be unreliable.

The challenge of unprecedented floods and droughts in risk management.

Risk management has reduced vulnerability to floods and droughts globally, yet their impacts are still increasing. An improved understanding of the causes of changing impacts is therefore needed, but has been hampered by a lack of empirical data. On the basis of a global dataset of 45 pairs of events that occurred within the same area, we show that risk management generally reduces the impacts of floods and droughts but faces difficulties in reducing the impacts of unprecedented events of a magnitude not previously experienced.

Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder.

Unlabelled: Changes of sphingolipid metabolism were suggested to contribute to the patho-etiology of major depression (MD) and bipolar disorder (BD). In a pilot study we assessed if lipid allostasis manifested in pathological plasma concentrations of bioactive lipids i.e.

Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder.

Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the BDNF val66met genotype, BDNF DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. We found a significant difference of methylation levels at CpG site 1-1-1 and 3-1-1 between MDD and healthy controls (p < 0.

Deprivation of root-derived resources affects microbial biomass but not community structure in litter and soil.

The input of plant leaf litter has been assumed to be the most important resource for soil organisms of forest ecosystems, but there is increasing evidence that root-derived resources may be more important. By trenching roots of trees in deciduous and coniferous forests, we cut-off the input of root-derived resources and investigated the response of microorganisms using substrate-induced respiration and phospholipid fatty acid (PLFA) analysis. After one and three years, root trenching strongly decreased microbial biomass and concentrations of PLFAs by about 20%, but the microbial community structure was little affected and the effects were similar in deciduous and coniferous forests.

The role of pre-, peri-, and postnatal risk factors in bipolar disorder and adult ADHD.

Gene-environment-development interactions are suggested to play a crucial role in psychiatric disorders. However, it is not clear if there are specific risk gene interactions with particular pre-, peri-, and postnatal risk factors for distinct disorders, such as adult attention-deficit-/hyperactivity disorder (aADHD) and bipolar disorder (BD). In this pilot study, the first aim was to investigate retrospective self-reports of pre-, peri-, and postnatal complications and risk factors from 126 participants (aADHD, BD, and healthy controls) and their mothers.

Assembly processes of trophic guilds in the root mycobiome of temperate forests.

Root-associated mycobiomes (RAMs) link plant and soil ecological processes, thereby supporting ecosystem functions. Understanding the forces that govern the assembly of RAMs is key to sustainable ecosystem management. Here, we dissected RAMs according to functional guilds and combined phylogenetic and multivariate analyses to distinguish and quantify the forces driving RAM assembly processes.

[Outpatient Psychosocial Cancer Care at a University Medical Center - Study Results Concerning Patient Characteristics and Care Needs].

Background: Psychosocial care for cancer patients has gained importance in recent years and psycho-oncological counselling centers (POCC's) offer a wide range of services in this area. We investigated the scope and content of a POCC at a university medical center.

Methods: The presented data were collected at the POCC at University Medical Center Leipzig in 2014.

Probabilistic, Multivariable Flood Loss Modeling on the Mesoscale with BT-FLEMO.

Flood loss modeling is an important component for risk analyses and decision support in flood risk management. Commonly, flood loss models describe complex damaging processes by simple, deterministic approaches like depth-damage functions and are associated with large uncertainty. To improve flood loss estimation and to provide quantitative information about the uncertainty associated with loss modeling, a probabilistic, multivariable Bagging decision Tree Flood Loss Estimation MOdel (BT-FLEMO) for residential buildings was developed.

Unveiling the molecular mechanism of self-healing in a telechelic, supramolecular polymer network.

Reversible polymeric networks can show self-healing properties due to their ability to reassemble after application of stress and fracture, but typically the relation between equilibrium molecular dynamics and self-healing kinetics has been difficult to disentangle. Here we present a well-characterized, self-assembled bulk network based on supramolecular assemblies, that allows a clear distinction between chain dynamics and network relaxation. Small angle x-ray scattering and rheological measurements provide evidence for a structurally well-defined, dense network of interconnected aggregates giving mechanical strength to the material.

Divergent habitat filtering of root and soil fungal communities in temperate beech forests.

Distance decay, the general reduction in similarity of community composition with increasing geographical distance, is known as predictor of spatial variation and distribution patterns of organisms. However, changes in fungal communities along environmental gradients are little known. Here we show that distance decays of soil-inhabiting and root-associated fungal assemblages differ, and identify explanatory environmental variables.

A Review of Flood Loss Models as Basis for Harmonization and Benchmarking.

Risk-based approaches have been increasingly accepted and operationalized in flood risk management during recent decades. For instance, commercial flood risk models are used by the insurance industry to assess potential losses, establish the pricing of policies and determine reinsurance needs. Despite considerable progress in the development of loss estimation tools since the 1980s, loss estimates still reflect high uncertainties and disparities that often lead to questioning their quality.

Early retirement in cancer patients with or without comorbid mental health conditions: a prospective cohort study.

Background: The authors investigated whether cancer patients who have comorbid mental health disorders (MD) are at greater risk of early retirement compared with those who do not have MD.

Methods: Individuals ages 18 to 55 years from a consecutive sample of patients who were admitted for inpatient oncologic treatment were interviewed using structured clinical interviews to ascertain MD. The patients were followed for 15 months, and the date of early retirement was documented.

Investigation of the different stable states of the cantilever oscillation in an atomic force microscope.

We present an algorithm which allows us to identify all possible stable states of the cantilever oscillation of an AFM operated in the intermittent contact mode within the harmonic approximation. The oscillatory states are qualified as quasi-free, net-attractive and net-repulsive solutions. Using a generic model for the tip-sample interaction the influence of a number of important experimental parameters on the state of oscillation is systematically studied.

Perspectives for motorcycle stability control systems.

On a global scale, motorcyclists are typically over-represented in crash statistics. This trend is increasing as although total road crashes and fatalities have decreased over the last fifteen years, motorcycle crash volumes have not. This paper describes the potential of stability control systems to help save motorcyclists' lives.

[Counselling centres for patients with cancer--analysis of service provision in Saxony].

Objectives: The aim of this study was to understand the quantity and quality of psychosocial services offered at counselling centres for outpatients with cancer in Saxony, a federal state of Germany.

Methods: Structured interviews with employees on site at the counselling centres in Saxony (N=30) and an analysis of their yearly reports were undertaken.

Results: The majority of the counselling centres (N=25) was situated at local health departments.

Interfacial polarization and field-induced orientation in nanostructured soft-ion conductors.

We study the effects of interfacial polarization in and upon a self-assembled ion conductor based on a lamellar block copolymer and a lithium salt. Impedance spectroscopy combined with orientation experiments enable a quantitative analysis of ionic polarization and a direct demonstration of its aligning effect on the interfaces. The time constant of the ionic polarization is larger as expected from Maxwell-Wagner-Sillars theory and attributed to diffusion effects.

Sewer modelling based on highly distributed calibration data sets and multi-objective auto-calibration schemes.

Pollutant load modelling for sewer systems is state-of-the-art, especially for the estimation of discharged pollutant loads and development of sewer management strategies. However, conventionally obtained calibration data sets are often not exhaustive and have significant drawbacks. In the Graz West catchment area (Graz, Austria), continuous high-resolution long-term online measurements for discharge and pollutant concentration have been carried out since 2002.

Determining the mobility of ions by transient current measurements at high voltages.

We present polarization and transient current experiments that allow an independent determination of the charge carrier density and the mobility of ions in polymer electrolytes at low charge carrier density. The method relies on a complete depletion of ions in the bulk electrolyte achieved by applying high voltages. Based on a qualitative model for the charge dynamics in this nonlinear regime, the method is exemplarily applied to a system of polymethylmethacrylate doped with small amounts of a lithium salt.

Dynamic shear modulus of glycerol: corrections due to instrument compliance.

A recent article by Shi et al. [J. Chem.

[Health promotion aspects in reorganization of a centralized operating department].

In many health care institutions (eg, hospitals), employees' health and satisfaction are not the main concern. However, if health and productivity are affected by high sickness rates and low motivation, health and satisfaction of the employees become important. This applies especially to hospitals engaged in acute patient care.

[Alfred Döblin (1878-1957). Notes on the cover picture].

Alfred Döblin studied medicine after completing his Abitur (A-levels). In 1905 he earned his doctorate under Alfred Hoche, director of the psychiatric clinic, by presenting a study on "Memory disorders in Korsakoff's psychosis." He subsequently worked as an assistant doctor in various psychiatric clinics until he switched to internal medicine in 1908.