Publications by authors named "Schroeder P"

Article Synopsis
  • The All of Us Research Program (AoU) aims to collect a diverse dataset from over one million people in the USA to enhance research on human diseases, focusing on genetic and phenotypic information.
  • This study developed and validated algorithms to identify cases of type 1 and type 2 diabetes using electronic health records and survey data, striving for improved accuracy in case-control studies.
  • The results showed the EHR-only algorithm had a better association with type 1 diabetes genetic scores, while the EHR+ algorithm was superior for type 2 diabetes, identifying significantly more cases than previous definitions and providing new validated definitions for both diabetes types.
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Background: Bovine tuberculosis (bTB) is the most important animal health concern in Wales. Annual testing across all cattle herds in Wales commenced in 2010. In 2017, a new geographic division of Wales was conceived, with bespoke cattle controls and eradication milestones reflecting the geographical heterogeneity of bTB distribution.

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  • Type 2 diabetes (T2D) genome-wide association studies (GWASs) typically miss rare genetic variants due to limitations in previous imputation methods and insufficient whole-genome sequencing data.
  • In a large-scale study involving over half a million individuals, researchers uncovered 12 new genetic variants linked to T2D, including a rare enhancer variant near the LEP gene that significantly increases risk.
  • The study also analyzed ClinVar variants related to monogenic diabetes, identifying additional rare variants that affect T2D risk and offering new insights into the pathogenicity of certain variants previously deemed uncertain.
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Plastic waste poses a significant challenge to achieving sustainable production and consumption of resources, particularly in sub-Saharan Africa where effective governance and waste management systems are lacking. In this paper, we develop an empirical understanding of the influence of public governance system on promoting circular economy (CE) for plastic actions among individuals. Through a survey of 1475 participants across five sub-Saharan African countries, we tested five hypotheses drawing on New Governance Theory and CE Action Recipe to explore the relationship between governance and individual's actions supporting CE for plastic.

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Objective: Electronic medical records (EMRs) have streamlined workflows for health care professionals, yet their full potential is not always actualized. Modern EMRs are often capable of generating automated prepopulated inpatient lists, however if these capabilities are not made available to inpatient teams or not designed with the end user in mind, resident physicians may be left to create alternative, manual solutions to ensure reliable and efficient care. The purpose of the current study was to longitudinally compare the impact of both manual and automated inpatient lists on resident education, wellness, and patient safety.

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Background: Overeating and obesity have been linked to deficient self-control and recent evidence suggests that the inhibitory spillover effect (ISE) may be an effective means to improve self-control. Specifically, it was shown that the ISE increases self-control by transfer of self-control capacity from one domain to another unrelated domain. Against this backdrop, our aim was to reduce hedonic food intake and body weight in non-dieting participants with overweight and obesity by transferring inhibitory control abilities from a food-unrelated domain to the food domain by means of an attribute conditioning procedure in a novel cognitive training (vs.

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Background: Mindfulness-based, in-person programs are effective at reducing stress and enhancing resilience in military and civilian samples, yet few studies have examined or compared training offered via real-time, interactive social media. Such a program would have a wider-reach and could include those unable to attend in-person. There is also interest in resolving ambiguity about the effects of mindfulness training on individual difference variables, such as self-compassion.

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Article Synopsis
  • * The study analyzed data from nearly 30,000 type 2 diabetes patients to see how genetic factors, particularly a specific variant, correlated with retinopathy risk, regardless of measured HbA1c levels.
  • * Findings revealed that those in the lowest genetic risk group experienced 20%-50% more retinopathy compared to higher-risk individuals, suggesting that genetic factors should inform personalized HbA1c targets for better diabetes management across different ancestries.
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  • Diabetes complications, like retinopathy and neuropathy, occur more frequently in individuals of African ancestry, partly due to G6PD deficiency which is associated with malaria resistance and lowers HbA1c levels by affecting red blood cell lifespan.
  • A study discovered a specific variant (rs1050828-T) linked to G6PD deficiency that increases the risk of diabetes complications, showing that glucose levels influence retinopathy risk significantly.
  • The findings suggest that adjusting diabetes management based on glucose levels or genetic factors could improve diagnosis and treatment, potentially reducing complications for those with G6PD deficiency.
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Background: Theoretical models and behavioural studies indicate faster approach behaviour for high-calorie food (approach bias) among healthy participants. A previous study with Virtual Reality (VR) and online motion-capture quantified this approach bias towards food and non-food cues in a controlled VR environment with hand movements. The aim of this study was to test the specificity of a manual approach bias for high-calorie food in grasp movements compared to low-calorie food and neutral objects of different complexity, namely, simple balls and geometrically more complex office tools.

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Article Synopsis
  • - The study evaluates the effectiveness of polygenic scores (PGS) in predicting type 2 diabetes (T2D) risk in diverse populations within US healthcare systems, focusing on patients who may seem low-risk based on their clinical traits.
  • - Researchers analyzed data from nearly 15,000 patients over 16 years, exploring how PGS correlates with T2D incidence under different clinical scenarios that included various health metrics and lifestyle factors.
  • - Findings indicate that PGS is a significant predictor of T2D risk, identifying individuals at high risk even when clinical evaluations suggest they are low risk, thus highlighting the potential of genetic information in patient assessments.
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Article Synopsis
  • The study aimed to find genetic risk factors for cardiovascular disease (CVD) in individuals with type 2 diabetes (T2D) through a genome-wide association approach.
  • Out of 49,230 T2D participants, 8,956 experienced incident CVD events, revealing three new genetic loci associated with increased CVD risk and confirming five known coronary artery disease variants.
  • The findings suggest both novel and established genetic factors contribute to CVD risk in T2D patients, highlighting the importance of genetic screening in this population.
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Etavopivat is an investigational, once daily, oral, selective erythrocyte pyruvate kinase (PKR) activator. A multicenter, randomized, placebo-controlled, double-blind, 3-part, phase 1 study was conducted to characterize the safety and clinical activity of etavopivat. Thirty-six patients with sickle cell disease (SCD) were enrolled into 4 cohorts: 1 single-dose, 2 multiple ascending doses, and 1 open-label (OL).

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Neuromodulation with transcranial direct current stimulation (tDCS) can transiently alter neural activity, but its spatial precision is low. High-definition (HD) tDCS was introduced to increase spatial precision by placing additional electrodes over the scalp. Initial evaluations of HD tDCS indicated polarity-specific neurophysiological effects-similar to conventional tDCS albeit with greater spatial precision.

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Article Synopsis
  • Type 2 diabetes (T2D) has a strong genetic component, and this study examined genetic data from over 1.4 million individuals across diverse populations to identify genetic clusters related to T2D.
  • Researchers used 650 T2D-related genetic variants to categorize individuals into 12 genetic clusters associated with different cardiometabolic traits, revealing variations in risk factors across populations including African, East Asian, and European ancestry.
  • The findings suggest that T2D risk varies by genetic background, with East Asians needing a lower body mass index (BMI) to have a similar T2D risk as Europeans, highlighting the complexity of genetic factors influencing T2D across different ancestries.
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Sewage sludge (biosolids) management represents a worldwide issue. Due to its valuable properties, approximately one half of the EU production is recovered in agriculture. Nevertheless, growing attention is given to potential negative effects deriving from the presence of harmful pollutants.

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Article Synopsis
  • Type 2 diabetes (T2D) is a complex disease influenced by various genetic factors and molecular mechanisms that vary by cell type and ancestry.
  • In a large study involving over 2.5 million individuals, researchers identified 1,289 significant genetic associations linked to T2D, including 145 new loci not previously reported.
  • The study categorized T2D signals into eight distinct clusters based on their connections to cardiometabolic traits and showed that these genetic profiles are linked to vascular complications, emphasizing the role of obesity-related processes across different ancestry groups.
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Neuromodulation with transcranial direct current stimulation (tDCS) is an increasingly popular research tool to experimentally manipulate cortical areas and probe their causal involvements in behavior, but its replicability and regional specificity are not clear. This registered report investigated cathodal tDCS effects on spatial-numerical associations (i.e.

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Objective: Food avoidance is central to patients with anorexia nervosa-restrictive type (AN-R). Competing accounts in experimental psychopathology research suggest that food avoidance may result from automatic, habitual responses or from elevated inhibitory control abilities. This study investigated behavioral trajectories of food avoidance in a novel virtual reality stopping task.

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Objectives: Tibiotalocalcaneal (TTC) nailing in the setting of acute ankle trauma has become increasingly popular. No consensus exists as to whether formal joint preparation is necessary, although there is some concern that residual motion at unprepared joints may lead to implant loosening and/or breakage. The objective of this study was to quantify the proportion of tibiotalar and subtalar articular surface destruction that occurs during reaming for TTC nail fixation.

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Recent upgrades providing two-dimensional divertor Thomson scattering (DTS-2D) measurements of Te and ne during a DIII-D plasma shot and a thorough description of system components and their functionality are presented. This system expands the capabilities of the existing single divertor Floor measurement location by introducing seven additional laser beam path options in the poloidal plane, spanning major radii from 1.062 to 1.

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Empirical evidence suggests fishes meet the criteria for experiencing pain beyond a reasonable doubt and zebrafish are being increasingly used in studies of pain and nociception. Zebrafish are adopted across a wide range of experimental fields and their use is growing particularly in biomedical studies. Many laboratory procedures in zebrafish involve tissue damage and this may give rise to pain.

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Human agents immersed in metaverse technologies such as virtual reality (VR) are routinely disconnected from their actual physical appearance and embodied in another virtual body, referred to as self-avatar. Such body transformations can have implications for patients with eating disorders, or persons with extreme body dissatisfaction (BD). Changes in BD, weight anxiety, or body image are theoretically linked to visual selective attention, which can be measured with eye tracking.

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