Fecal blood loss in patients with colonic polyps: a comparison of measurements with 51chromium-labeled erythrocytes and with the Haemoccult test.

The quantitative determinations of fecal daily blood loss after intravenous administration of 51Cr-labeled erythrocytes in 44 patients with colonic polyps and in 11 controls were compared with the results of the daily performed Haemoccult test without dietary restrictions. A total of 642 stool specimens was analyzed for 51Cr loss and the Haemoccult test. The mean fecal daily blood loss in the 34 patients with adenomatous polyps of the descending colon and rectosigmoid was 1.

Immunoselection of tumor cell variants by mice suppressed with ultraviolet radiation.

It has previously been shown that mice exposed to ultraviolet radiation (UV) fail to reject highly immunogenic UV-induced tumors, which are regularly rejected by normal mice. The present study shows, however, that this immunosuppresion is incomplete, as UV-treated mice can still mount certain tumor-specific immune responses and reject smaller inocula of tumor cells that regularly grow progressively in athymic nude mice. Furthermore, all tumor cell lines that were reisolated from the tumor mass resulting from one tumor passage through UV-treated recipients heritably lost a tumor-specific determinant present on the parental tumor cells used for transplantation, and a large percentage of these reisolated variant tumors had changed to progressively growing tumors, in that they were no longer rejected by normal mice.

[Angiography after interventions on the pancreas].

The angiograms of 35 patients who had had surgery of the pancreas were evaluated. One must distinguish between the changes due to the procedure and those due to the original disease or to progress or recurrence of tumours. Out of four patients with recurrence of a pancreatic carcinoma, the angiogram failed to show any evidence in three.

Changes in susceptibility to cytotoxic antibody among tumor cells surviving exposure to chemotherapeutic agents.

We determined that myeloma cells which survived drug treatment had an altered sensitivity to cytotoxic antibody. The effects of several chemotherapeutic agents differing in drug action were compared. The antiserum was directed against viral determinants on the surface of S107 myeloma cells.

[Gastroesophageal reflux and gastric secretion].

In 47 patients with reflux complaints and pH-metrically recognizable gastrooesophageal reflux (glass-calomel-electrode system) we succeeded in proving the fact that a large volume of gastric secretion and a lower intragastric pH-value are concomitant with a significant prolongation of the total reflux duration by increase of the reflux frequency.

Mechanisms of syngeneic tumor rejection. Susceptibility of host-selected progressor variants to various immunological effector cells.

The ultraviolet radiation-induced fibrosarcoma 1591 generally is rejected by normal syngeneic mice and only rarely exhibits progressive growth. We isolated five of these rare progressor tumors from normal animals to determine the selective pressures that had been exerted upon the parental tumor by normal immunocompetent hosts. We found that the variant tumor cell lines could neither induce nor be killed by tumor-specific lymphocytes, suggesting that selection had been exerted against tumor cells expressing the tumor-specific antigen.

[Bauhin's valve syndrome].

The syndrome of the ileocecal valve is a rare and rather unknown disease. Its clinical diagnosis is very difficult. The symptoms are those of the transient, periodic small bowel obstruction.

[Prognostic criteria for ulcer closure (author's transl)].

A retrospective study was made based on 243 patients with simple closure of a perforated peptic ulcer in order to analyse factors influencing the results. Complications and mortality showed a good correlation with age, time between onset of symptoms and operation and size of the perforation, but no correlation with ulcer localization and history. Between 1 and 15 years after the operation, 39,4% of the patients were asymptomatic, 34,8% under conservative treatment, whilst 25,8% had to be reoperated on in the meantime.

Loss of tumor-specific and idiotype-specific immunity with age.

The ultraviolet light-induced fibrosarcoma 1591 undergoes "first-set rejection" when transplanted into normal syngeneic mice. We found, however, that the primary resistance of normal mice decreases with age, beginning at 9--12 mo, equivalent to middle age for mice. Mice lose with age the capacity to mount both idiotypic and anti-idiotypic responses responsible for controlling the growth of tumor.

[Survival in heat (author's transl)].

The clinical characteristics of heat effect are presented in detail, the significance of risk factors emphasized. The demands on an optimal system for treatment of heat are discussed. Medical measures include cooling, treatment for shock, supply of water and salt, controlling acidosis, treatment of coagulation disorders.

Gut-hormone profile in totally pancreatectomised patients.

In eight totally pancreatectomised patients the release of the relevant gut hormones was determined after a standard test meal. Plasma levels of pancreatic glucagon were not significantly different from zero in our series of pancreatectomised patients. Pancreatic polypeptide was undetectable.

[The effect of neostigmine and atropine on gastro-oesophageal reflux (author's transl)].

During 6 hours continuous pH-measurements were undertaken to study the effect of neostigmine (0,5 mg s.c.) and atropine (0,5 mg s.