Are Nomograms Useful for Predicting Sentinel Lymph Node Status in Melanoma Patients?

Background And Objectives: Clinical nomograms have been developed to predict sentinel lymph node (SLN) status in early-stage melanoma patients, but the clinical utility of these tools remains debatable. We created and validated a nomogram using data from a randomized clinical trial and assessed its accuracy against the well-validated Melanoma Institute Australia (MIA) nomogram.

Methods: We developed our model to predict SLN status using logistic regression on clinicopathological patient data from the Multicenter Selective Lymphadenectomy Trial-I.

Phosphonium SF Salts Derived from Sulfur Hexafluoride as Deoxyfluorination Reagents.

Sulfur based deoxyfluorination reagents are usually derived from the corrosive gas SF. Herein, we report the synthesis and properties of an easily accessible phosphonium salt [(tmg)PF]SF (1) which was obtained from the reaction of sulfur hexafluoride (SF) with tris(tetramethylguanidinyl)phosphine. The performance of this crystalline SF salt as a reagent in deoxyfluorination reactions was investigated together with a second SF salt [(R)PF]SF (2) containing bulky substituents (R=1,3-di-tert-butylimidazolidin-2-ylidenamino).

Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine.

Histone deacetylase 6 (HDAC6) is an emerging drug target to treat oncological and non-oncological conditions. Since highly selective HDAC6 inhibitors display limited anticancer activity when used as single agent, they usually require combination therapies with other chemotherapeutics. In this work, we synthesized a mini library of analogues of the preferential HDAC6 inhibitor HPOB in only two steps via an Ugi four-component reaction as the key step.

The role of conflict representation in abstinence versus moderation in self-control.

Self-control-the prioritization of valued global goals over immediate local rewards-is typically conceptualized and studied as isolated decisions. Goal pursuit, however, generally requires people to make repeated self-control decisions across contexts. We adopt a higher order, strategic level of analysis of self-control and explore, for the first time, people's preferences for abstinence (a pattern of choices in which one never indulges) versus moderation (a pattern of choices in which one indulges when doing so does not harm one's goals or even helps promote the pursuit of those goals).

Exploring the Genomic Landscape of Hepatobiliary Cancers to Establish a Novel Molecular Classification System.

Taxonomy of hepatobiliary cancer (HBC) categorizes tumors by location or histopathology (tissue of origin, TO). Tumors originating from different TOs can also be grouped by overlapping genomic alterations (GA) into molecular subtypes (MS). The aim of this study was to create novel HBC MSs.

Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties.

Histone deacetylases (HDACs) are a class of enzymes that cleave acyl groups from lysine residues of histone and non-histone proteins. There are 18 human HDAC isoforms with different cellular targets and functions. Among them, HDAC6 was found to be overexpressed in different types of cancer.

Detecting Protein-Ligand Interactions with Nitroxide Based Paramagnetic Cosolutes.

NMR spectroscopy techniques can provide important information about protein-ligand interactions. Here we tested an NMR approach which relies on the measurement of paramagnetic relaxation enhancements (PREs) arising from analogous cationic, anionic or neutral soluble nitroxide molecules, which distribute around the protein-ligand complex depending on near-surface electrostatic potentials. We applied this approach to two protein-ligand systems, interleukin-8 interacting with highly charged glycosaminoglycans and the SH2 domain of Grb2 interacting with less charged phospho-tyrosine tripeptides.

Metamotivational beliefs about intrinsic and extrinsic motivation.

Although intrinsic motivation is often viewed as preferable to more extrinsic forms of motivation, there is evidence that the adaptiveness of these motivational states depends on the nature of the task being completed (e.g., Cerasoli et al.

Corrigendum: The relationship between metamotivational knowledge and performance.

[This corrects the article DOI: 10.3389/fpsyg.2023.

In it together: Shared reality with instrumental others is linked to goal success.

[Correction Notice: An Erratum for this article was reported online in on Sep 07 2023 (see record 2024-05962-001). In the original article, the abstract was revised. Specifically, there were errors in the the second and third sentences of the fifth paragraph of the Shared Reality section, fifth sentence of the Present Research section, An updated Figure 1 now appears in the erratum.

The relationship between metamotivational knowledge and performance.

Self-regulation research highlights the performance trade-offs of different motivational states. For instance, within the context of regulatory focus theory, promotion motivation enhances performance on eager tasks and prevention motivation enhances performance on vigilant tasks (i.e.

Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors.

Multi-target drugs (MTDs) are emerging alternatives to combination therapies. Since both histone deacetylases (HDACs) and cyclooxygenase-2 (COX-2) are known to be overexpressed in several cancer types, we herein report the design, synthesis, and biological evaluation of a library of dual HDAC-COX inhibitors. The designed compounds were synthesized via an efficient parallel synthesis approach using preloaded solid-phase resins.

Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity.

In this work, we utilized the proteolysis targeting chimera (PROTAC) technology to achieve the chemical knock-down of histone deacetylase 6 (HDAC6). Two series of cereblon-recruiting PROTACs were synthesized via a solid-phase parallel synthesis approach, which allowed the rapid preparation of two HDAC6 degrader mini libraries. The PROTACs were either based on an unselective vorinostat-like HDAC ligand or derived from a selective HDAC6 inhibitor.

Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.

Using a microwave-assisted protocol, we synthesized 16 peptoid-capped HDAC inhibitors (HDACi) with fluorinated linkers and identified two hit compounds. In biochemical and cellular assays, stood out as a potent unselective HDACi with remarkable cytotoxic potential against different therapy-resistant leukemia cell lines. demonstrated prominent antileukemic activity with low cytotoxic activity toward healthy cells.

Examining Beliefs About the Benefits of Self-Affirmation for Mitigating Self-Threat.

Self-affirmation-reflecting on a source of global self-integrity outside of the threatened domain-can mitigate self-threat in education, health, relationships, and more. Whether people recognize these benefits is unknown. Inspired by the metamotivational approach, we examined people's beliefs about the benefits of self-affirmation and whether individual differences in these beliefs predict how people cope with self-threat.

Tailored GuideLine Implementation in STrokE Rehabilitation (GLISTER) in Germany. Protocol of a Mixed Methods Study Using the Behavior Change Wheel and the Theoretical Domains Framework.

Objective: Evidence-based guidelines are important for informing clinical decision-making and improving patient outcomes. There is inconsistent usage of guidelines among physical therapists involved in stroke rehabilitation, suggesting the existence of a gap between theory and practice. Addressing the German guideline "evidence-based rehabilitation of mobility after stroke (ReMoS)," the aims of this project are (1) to describe the current physical therapy practice within the context of stroke rehabilitation in Germany, (2) to evaluate barriers and facilitators of guideline usage, (3) to develop, and (4) to pilot test a theory-based, tailored implementation intervention for the benefit of guideline recommendations.

Current physical therapy practice and implementation factors regarding the evidence-based 'Rehabilitation of Mobility after Stroke (ReMoS)' guideline in Germany: a cross-sectional online survey.

Background: Evaluation of the current physical therapy practice for German stroke rehabilitation with respect to the 'Rehabilitation of Mobility after Stroke (ReMoS)' guideline recommendations and the associated implementation factors.

Methods: A descriptive cross-sectional study employing an online survey was performed among German physical therapists in 2019. The survey consisted of three sections with open and closed questions: 1) self-reported use of ReMoS recommendations, 2) barriers of guideline use and 3) socio-demographic characteristics.

Goal progress velocity as a determinant of shortcut behaviors.

Employees often have a great deal of work to accomplish within stringent deadlines. Therefore, employees may engage in which involve eschewing standard procedures during goal pursuit to save time. However, shortcuts can lead to negative consequences such as poor-quality work, accidents, and even large-scale disasters.

Melting COVID-frozen goals: How goal disengagement supports well-being during the COVID-19 pandemic.

Unlabelled: The current research addresses dynamics of the COVID-19 pandemic's disruption to goal pursuit. Specifically, we examined the effects of disengaging from frozen goals (goals for which progress had been disrupted due to COVID-19). In May 2021, we asked participants ( = 226) what percentage of their goals were COVID-frozen goals and asked them to report their engagement in one such goal (vs.

Disparities in the impact of the AJCC 8th edition staging system on differentiated thyroid cancer outcomes.

Background: The impact of AJCC8 among self-reported racial/ethnic groups on differentiated thyroid cancer (DTC) outcomes is unknown.

Methods: Multivariate-regression evaluated the association between AJCC7 to AJCC8 stage change and race/ethnicity in patients with DTC in the NCDB. Cox-proportional-regression evaluated whether AJCC7 to AJCC8 stage change affects overall survival (OS) differently based on reported race/ethnicity.

Creativity, Boredom Proneness and Well-Being in the Pandemic.

Throughout the course of the pandemic, it has become clear that the strictures of social isolation and various levels of lockdown constraints have impacted people's well-being. Here, our aim was to explore relations between trait dispositions associated with boredom proneness, self-regulation and well-being using data collected early in the pandemic. Specifically, we explored whether the tendency to engage in everyday creative pursuits (e.

Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors.

Herein we report the structure-activity and structure-physicochemical property relationships of a series of class I selective ortho-aminoanilides targeting the "foot-pocket" in HDAC1&2. To balance the structural benefits and the physicochemical disadvantages of these substances, we started with a set of HDACi related to tacedinaline (CI-994) and evaluated their solubility, lipophilicity (log D ) and inhibition of selected HDAC isoforms. Subsequently, we selected the most promising "capless" HDACi and transferred its ZBG to our previously published scaffold featuring a peptoid-based cap group.