Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19.

Although initial immunophenotypical studies on peripheral blood and bronchoalveolar lavage samples have provided a glimpse into the immunopathology of COVID-19, analyses of pulmonary draining lymph nodes are currently scarce. 22 lethal COVID-19 cases and 28 controls were enrolled in this study. Pulmonary draining lymph nodes (mediastinal, tracheal, peribronchial) were collected at autopsy.

[Weight discordance of the second twin: effect on perinatal morbidity and mortality. An 8-year analysis of 213 twin deliveries].

In this retrospective eight-years-study we examine factors to be considered responsible for higher perinatal mortality in twins, especially in twins with discordant body weight. As a main risk factor for this we find vaginal delivery, i.e.

[Epidemiological indications for the etiology of proteinuria, hypertension in pregnancy and pre-eclampsia--a longitudinal cohort studies of all Swedish women giving birth between 1973 and 1981 to 3 singleton infants].

Based on centrally recorded data about all pregnancies that led to delivery in Sweden in the years from 1973 to 1981 this longitudinal study considers the course of pregnancies of all women who gave birth to their first three single babies during observation time especially regarding hypertension, proteinuria, pre-eclampsia and eclampsia-here subsumized under HP-disease. Incidence of HP-disease is shown to be 8.1% of all observed women, depending on the theoretical approach at a minimum of 34% and a maximum of 44% being due to primary, pregnancy-induced HP-disease.

Capillary versus arterial plasma catecholamines as markers for sympatho-adrenal activity in infants.

In this study, we investigated whether capillary plasma catecholamines can be used as a suitable substitute for arterial catecholamines. Analysis was done radioenzymatically. Catecholamine concentrations were not different in arterial and simultaneously collected "arterialized" (warmed foot) capillary plasma obtained by heel-prick from 18 neonatal intensive care patients as assessed by linear regression analysis (correlation coefficient: 0.

[Exogenous allergic alveolitis (bird fancier's lung)].

A 13 year old boy was admitted to our clinic because of caugh, dyspnoe, tachypnoe and bilateral fine moist rales since more than 6 months. Pulmonary function studies showed a restrictive lung disease. Lung biopsy revealed an interstitial pneumonitis.

[Juvenile nonspecific spondylodiscitis].

In the case of an 11-years old boy, diagnosis "Juvenile Spondylodiscitis" finally was established by MRI. X-Ray investigation was negative and bone scintigraphy was interpreted negative or not conclusive. In recently published studies using MRI for diagnosis of spondylodiscitis in children younger than six years, a typically MCR signal of involved disc and vertebral body was found at a stage of investigation when bone scintigraphy had already also been conclusive.

Antimicrobial chemotherapy in patients with cystic fibrosis.

The treatment of exacerbations of pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis is unsatisfactory. Serum concentrations and urinary excretion of cephalexin, epicillin, azlocillin, ticarcillin, trimethoprim-sulfa and gentamicin useful in the treatment of these infections were investigated in cystic fibrosis patients suffering from pulmonary infections. The data were compared to those found in non-cystic fibrosis children treated with antibiotics for other reasons.

Breath holding in divers and non-divers--a reappraisal.

The two phases of breath holding, the voluntary inactive and involuntary active phases, were identified by non-invasive methods using the induction plethysmograph. Eight trained divers and 7 non-diving control subjects familiar with respiratory apparatus were studied. During breath holding from normocapnia and total lung capacity it was not possible to distinguish between the two groups in respect of the pattern or duration of breath holding or alveolar gas tensions at the breakpoint.

Rheumatoid non-lymphoid synovial cells and the induction of mixed leukocyte reactions. Low-density preparations containing Ia+ macrophages and dendritic cells are less stimulatory than peripheral blood non-T cells.

Interactions of autologous or allogeneic T cells with non-lymphoid synovial cells were investigated to study the mechanisms of T-cell activation in rheumatoid arthritis. The synovial cell fraction obtained by Percoll gradients contained an average of 31% cells positive for monocyte antigens and 62% intensely Ia-positive cells. Tissue cultures demonstrated large numbers of cells with a dendritic morphology.

Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study.

The presence of contractile proteins in human cancer cells has been studied by means of: a) immunofluorescent staining using specific antibodies, and b) electron microscopy in order to detect the presence of cytoplasmic filaments. The tissues examined were: normal human skin, basal cell carcinoma of the skin, squamous cell carcinomas (of skin, oral cavity, and larynx), normal nonlactating mammary gland, and infiltrating mammary carcinoma with or without fibrosis. Normal tissues were negative after immunnoflurosescent staining of contractile proteins and contained no or minimal amounts of microfilaments as judged by electron microscopy.