Left ventricular rigor mortis interferes with postmortem aortic root geometry.

Aortic regurgitation is a common valve disease and can be caused by delineated findings such as fenestrations or hardly discernible alterations of the aortic root geometry. Therefore, aortic regurgitation can be a challenging diagnosis during an autopsy. Cardiac surgeons, however, are confronted with comparable problems during surgery and have developed a refined knowledge of the anatomy of the aortic root including its geometry.

Ultra-stable transportable ultraviolet clock laser using cancellation between photo-thermal and photo-birefringence noise.

Optical clocks require an ultra-stable laser to probe and precisely measure the frequency of the narrow-linewidth clock transition. We introduce a portable ultraviolet (UV) laser system for use in an aluminum quantum logic clock, demonstrating a fractional frequency instability of approximately mod   = 2 × 10. The system is based on an ultra-stable cavity with crystalline AlGaAs/GaAs mirror coatings, with a frequency quadrupling system employing two single-pass second-harmonic generation (SHG) stages.

Examining Gravettian and Magdalenian mobility and technological organization with IR spectroscopy.

Archaeologists can use the provenance of lithic raw materials to examine the movements, territories, and settlement dynamics of hunter-gatherers. Several studies have used macroscopic analyses to propose the long-distance transport of raw material during the Gravettian and the Magdalenian of the Swabian Jura in Central Europe. Until now hypotheses about raw material transport in this region were not based on reproducible analyses.

Differentially expressed messenger RNA isoforms in beef cattle skeletal muscle with different fatty acid profiles.

This study aimed to identify mRNA isoforms that were expressed differently in the muscle tissue of Nellore cattle based on their intramuscular fatty acid profile. Forty-eight young bulls were used to quantify beef fatty acids (FA) and perform RNA sequencing analysis. The young bulls were divided into three different groups based on quantifying FA using k-means analysis.

Association Between Unemployment and Mental Disorders: A Narrative Update of the Literature.

The relationship between unemployment and mental disorders has been a significant subject of study since at least the Industrial Revolution. However, most data show associations of unemployment and isolated mental disorders, and this study field has been neglected in the last years. Therefore, this narrative review aims to provide an updated overview of the association between unemployment and mental health in general as well as the most prevalent mental disorders.

Efficacy of different intraarticular injection materials in the arthrocentesis of arthrogenic temporomandibular disorders: A systematic review and network meta-analysis of randomized controlled trials.

Purpose: Arthrogenic temporomandibular disorders (TMDs) that do not respond to conservative treatment necessitate the use of semi-conservative methods, such as arthrocentesis. However, the ranking of intraarticular devices used in arthrocentesis remains controversial. Therefore, a network meta-analysis and systematic review were conducted to compare the different materials used for arthrocentesis.

N-mixture models with camera trap imagery produce accurate abundance estimates of ungulates.

Abundance estimates inform ungulate management and recovery efforts. Yet effective and affordable estimation techniques remain absent for most ungulates lacking identifiable marks and inhabiting rugged or highly vegetated terrain. Methods using N-mixture models with camera trap imagery form an appealing solution but remain unvalidated.

Loneliness and social anxiety in the general population over time - results of a cross-lagged panel analysis.

Background: Loneliness has become a major public health issue of the recent decades due to its severe impact on health and mortality. Little is known about the relation between loneliness and social anxiety. This study aimed (1) to explore levels of loneliness and social anxiety in the general population, and (2) to assess whether and how loneliness affects symptoms of social anxiety and vice versa over a period of five years.

Lymphoplasmacytic Lymphoma Presenting as Severe Secondary Raynaud's Phenomenon.

Primary Raynaud's phenomenon (RP) is a common and self-limiting condition, which is not secondary to any other disease process. In contrast, secondary RP has an underlying etiology. Several conditions can lead to secondary RP, which creates a challenging landscape for clinicians.

A review of Malipatilius (Hemiptera: Heteroptera: Rhyparochromidae), with a checklist of Lygaeoidea occurring in the Papuan Subregion.

The genus Malipatilius Kondorosy, 2013 is redescribed, 8 new species are described (M. batantensis sp. nov.

Cortisol and ACTH response to Dex/CRH testing and 24-hour urine free cortisol levels in women with and without premenstrual dysphoric disorder.

Hyperactive and hyperreactive HPA axis functions are frequently reported in depressive disorders, particularly in major depression. However, research into HPA axis function in women with premenstrual dysphoric disorder (PMDD), which is also classified as a depressive disorder, has shown inconsistent results. This study aimed to characterize the HPA axis in women with PMDD using the combined dexamethasone suppression and CRH stimulation (Dex/CRH) test, alongside measurements of 24-hour urine free cortisol (UFC).

Elemental stoichiometry and insect chill tolerance: evolved and plastic changes in organismal Na+ and K+ content in Drosophila.

Acclimation and evolutionary adaptation can produce phenotypic changes that allow organisms to cope with challenges. Determining the relative contributions and the underlying mechanisms driving phenotypic shifts from acclimation and adaptation is of central importance to understanding animal responses to change. Rates of evolution have traditionally been considered slow relative to ecological processes that shape biodiversity.

Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs.

Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modifications in their chemical structure, e.g.

Definitional Challenges in Understanding Hypertrophic Cardiomyopathy.

Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy. It is often caused by mutations of genes encoding for sarcomeric or sarcomere-associated proteins. Despite its clinical importance, divergent definitions are published by major cardiology societies.

Ultra-low frequency noise external cavity diode laser systems for quantum applications.

We present two distinct ultra-low frequency noise lasers at 729 nm with a fast frequency noise of 30 Hz/Hz, corresponding to a Lorentzian linewidth of 0.1 kHz. The characteristics of both lasers, which are based on different types of laser diodes, are investigated using experimental and theoretical analysis with a focus on identifying the advantages and disadvantages of each type of system.

Toxicokinetic modelling of the synthetic cannabinoid 5F-MDMB-P7AICA and its main metabolite in pigs following pulmonary administration.

Aims: Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so-called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.

Adamantane-Type Nitridophosphate Phosphors AELiPN : Eu2 via Medium-Pressure Ion-Exchange Reactions.

Nitridophosphates have emerged as promising host compounds in the field of solid-state lighting. Their industrial relevance has increased significantly, mainly due to recent advances in synthetic approaches under medium-pressure (MP) conditions, including ammonothermal synthesis and hot isostatic pressing (HIP). In this study, we report on the synthesis and characterization of the quaternary representatives CaLiPN (x=2, 2.

Evaluation of the therapeutic relevance of architectural aspects in child and adolescent psychiatric institutions from the perspective of architects and senior physicians.

Objective: The concept of "Healing Architecture" addresses the relevance of design and architectural issues on the outcome of medical and therapeutic treatment in hospitals. The questionnaire ARCHI was developed to record data on the opinion of different groups of users on the architectural design of their therapeutic environment in departments of child and adolescent psychiatry.

Method: A Questionnaire-based cross-sectional study was conducted in two phases between 2020 and 2022 using ARCHI to gather the perspectives of senior physicians and architects on the significance of architectural design in German child and adolescent psychiatric facilities.

Pervasive fitness trade-offs revealed by rapid adaptation in large experimental populations of .

Life-history trade-offs are an inherent feature of organismal biology that evolutionary theory posits play a key role in patterns of divergence within and between species. Efforts to quantify trade-offs are largely confined to phenotypic measurements and the identification of negative genetic-correlations among fitness-relevant traits. Here, we use time-series genomic data collected during experimental evolution in large, genetically diverse populations of to directly measure the manifestation of trade-offs in response to temporally fluctuating selection pressures on ecological timescales.

Dominance reversal maintains large-effect resistance polymorphism in temporally varying environments.

A central challenge in evolutionary biology is to uncover mechanisms maintaining functional genetic variation1. Theory suggests that dominance reversal, whereby alleles subject to fluctuating selection are dominant when beneficial and recessive when deleterious, can help stabilize large-effect functional variation in temporally varying environments2,3. However, empirical evidence for dominance reversal is scarce because testing requires both knowing the genetic architecture of relevant traits and measuring the dominance effects on fitness in natural conditions4.

Circular dichroism in multiphoton ionization of resonantly excited helium ions near channel closing.

The circular dichroism (CD) of photoelectrons generated by near-infrared (NIR) laser pulses using multiphoton ionization of excited He ions in the 3p(m= +1) state is investigated. The ions were prepared by circularly polarized extreme ultraviolet (XUV) pulses. For circularly polarized NIR pulses co- and counter-rotating relative to the polarization of the XUV pulse, a complex variation of the CD is observed as a result of intensity- and polarization-dependent Freeman resonances, with and without additional dichroic AC-Stark shifts.

Implementing Competency-Based Veterinary Education: A Survey of AAVMC Member Institutions on Opportunities, Challenges, and Strategies for Success.

Competency-based education is increasingly being adopted across the health professions. A model for competency-based education in veterinary medicine was recently developed by a working group of the American Association of Veterinary Medical Colleges (AAVMC) and is being used in institutions worldwide. The purpose of this study was to gather information on progress in and barriers to implementing competency-based education (including use of the AAVMC competency-based veterinary education [CBVE] Model) by AAVMC member schools to inform the development of strategies to support institutions in successful implementation of the CBVE Model.

Clinical Year Veterinary Students' Expectations of New Graduate Independence Exceed Their Self-Perceived Competence and Expectations of Community Practitioners.

Veterinary medicine is unique in that graduating veterinarians can be licensed to practice independently at the time of graduation. A veterinary curriculum needs to not only prepare graduate veterinarians to meet the expectations of their professional community but also ensure those veterinarians have an accurate perception of expected job requirements. This paper evaluates and compares veterinary students' perceived expectations of graduate-level independence with their self-perceived competence over their clinical (fourth) year.

Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood-brain barrier permeability in female CLP mice.

Background: Septic encephalopathy is frequent but its pathophysiology is enigmatic. We studied expression of neurotransmitters, inflammation and integrity of the blood-brain barrier (BBB) in several brain regions during abdominal sepsis. We compared mice with either lethal or surviving phenotype in the first 4 sepsis days.