Rhabdomyolysis Caused by Isotretinoin and Exercise in an Otherwise Healthy Female Patient.

Acne vulgaris is one of the most common skin conditions treated by healthcare providers. Isotretinoin is a well-known and effective treatment for nodulocystic and scarring acne. Rarely, and usually in combination with exercise, patients treated with isotretinoin can develop rhabdomyolysis, a potentially life-threatening breakdown of muscle associated with elevated creatine kinase (CK).

Painful Scalp Nodules on an Active-Duty Sailor.

Lesions of the scalp can present a challenging differential diagnosis to the primary care provider, especially in remote military settings where specialist care is not immediately available. Scalp lesions can be painful and disfiguring, and cause duty limitations if they interfere with the donning of personal protective equipment such as helmets, hardhats, or firefighting gear. We present a case of dissecting scalp cellulitis on an active- duty Navy Sailor who was leaving on an extended underway period on his ship the next day.

Protein kinase D1 is essential for bone acquisition during pubertal growth.

Bone formation and maintenance represents the summation of the balance of local and endocrine hormonal stimuli within a complex organ. Protein kinase D (PKD) is a member of the Ca(2+)/calmodulin-dependent kinase superfamily of serine/threonine kinases and has been described as the crossroads for the bone morphogenetic protein (BMP)-IGF-I signaling axis, which plays a major role in bone formation. The current study exploits the PKD1-deficient mouse model to examine the role of PKD in vivo in the skeleton.