[The value of parameters of iron metabolism in the differential diagnosis of anemias].

As a result of investigations into the diagnostic validity of selected haematologic-morphological and clinical-chemical test factors of iron metabolism in the diagnosis of hypochromic anaemia, the examined test faktora are differently evaluated as individual parameters and in their combination. 1. Haematocrit (PCV) is equal to the determination of haemoglobin concentration as a search parameter.

[The first clinical experience with cryopreserved erythrocyte concentrate].

After a brief illustration of the manufacturing procedure for frozen stored erythrocyte concentrate (GK-EK) the compatibility and transfusion success are assessed by means of clinical and laboratory-chemical parameters. Ensured febrile transfusion responses could not be observed. Indications for GK-EK are given.

[Optimizing the diagnosis of anemia].

The specific value of the erythrocyte parameters MCH and MCV for the differential-diagnostic arrangement of anaemias to the use of the haematological automations of analysis PHA 1/2 is represented. A prerequisite is the precise determination of haemoglobin concentration and erythrocyte number. MCHC has no sufficient discriminatory capacity.

[Comparative study of the efficacy of the DBVCy protocol (daunoblastin, bleomycin, vincristine, cytostasan) and the ABVD protocol in advanced Hodgkin's lymphoma. A prospective inter-clinic study within the framework of the Hauptforschungsrichtung Geschwulsterkrankungen].

In MOPP-resistant patients with Hodgkin-lymphoma stage III B and IV the well known ABVD-protocol was compared with the DBVCy-protocol (daunorubicin, bleomycin, vincristine, cytostasan) in a randomized prospective trial. 73 patients were evaluable, 35 received ABVD, 38 DBVCy. 4 out of 35 (11%) in the ABVD-group and 9 out of 38(24%) in the DBVCy-group reached complete remission.

Winding anomalies in nuclear DNA from malignant cells. I. Experimental evidence.

The superhelical properties of nuclear DNA from malignant cells of human origin (leukemic cell lines Reh and D-562, mesothelioma cell line, and peripheral blood monocytes from acute monocytic leukemia) were investigated in neutral sucrose gradients with ethidium bromide. As compared with the universal superhelical density of nuclear DNA from normal cells, the DNA released from malignant cells showed a substantially higher negative superhelix content, equivalent to an increased deficiency in right-handed DNA duplex turns. In regard to analogous results obtained from other malignant cell systems, the extremely underwound structural state of nuclear DNA appears to be a feature common to malignant cells.

[The use of erythrocyte concentrates, preserved at low temperature, in hematologic patients].

The transfusion protocols of 70 patients with haematological diseases were evaluated and compared. 68 patients of them received frozen erythrocyte concentrates stored at low temperatures (TTK-EK). A total of 1,183 courses of transfusion with 2,744 transfusion units (TE) were examined for erythrocyte substitution.