Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na/H exchange, but apical proton uptake is undefined. We found high expression of the Cl/H exchanger ClC3 at the bone apical surface.
View Article and Find Full Text PDFBackground: Rental assistance programs have been linked to better housing quality, stability, healthcare access, and reduced likelihood of uncontrolled diabetes. However, its direct association with diabetes screening is uncertain.
Objective: To determine whether federal rental assistance programs are associated with lower odds of undiagnosed diabetes.
The phosphodiesterase enzymes mediate calcium-phosphate deposition in various tissues, although which enzymes are active in bone mineralization is unclear. Using gene array analysis, we found that a member of ecto-nucleotide pyrophosphatase/phosphodiesterase family, ENPP2, was strongly down-regulated with age in stromal stem cells that produce osteoblasts and make bone. This is in keeping with reduced bone formation in older animals.
View Article and Find Full Text PDFWe review unique properties of bone formation including current understanding of mechanisms of bone mineral transport. We focus on formation only; mechanism of bone degradation is a separate topic not considered. Bone matrix is compared to other connective tissues composed mainly of the same proteins, but without the specialized mechanism for continuous transport and deposition of mineral.
View Article and Find Full Text PDFWe studied osteoblast bone mineral transport and matrix proteins as a function of age. In isolated bone marrow cells from long bones of young (3 or 4 mo) and old (18 or 19 mo) mice, age correlated with reduced mRNA of mineral transport proteins: alkaline phosphatase (ALP), ankylosis (ANK), the Cl/H exchanger ClC3, and matrix proteins collagen 1 (Col1) and osteocalcin (BGLAP). Some proteins, including the neutral phosphate transporter2 (NPT2), were not reduced.
View Article and Find Full Text PDFAim: To reveal the heterogeneity of ex vivo-cultured human mesenchymal stromal cells derived from either masticatory or lining oral mucosa.
Materials And Methods: Cells were retrieved from the lamina propria of the hard palate and alveolar mucosa of three individuals. The analysis of transcriptomic-level differences was accomplished using single-cell RNA sequencing.
In 2016, only one in five eligible U.S. households received rental assistance and waiting lists averaged two years nationally.
View Article and Find Full Text PDFBackground: Despite the limitations the carceral environment may impose on mental wellness, mental healthcare is increasingly becoming a carceral endeavor. Over the course of the last several decades, prisons and jails have become the de facto mental healthcare provider for thousands of incarcerated individuals. Furthermore, practices like mandated mental healthcare for supervised individuals further broaden the population experiencing mental healthcare within the criminal legal system at large.
View Article and Find Full Text PDFImportance: Programs that provide affordable and stable housing, such as federal rental assistance, may be associated with improved mean blood glucose levels and related diabetes outcomes.
Objective: To assess whether 2 different types of federal rental assistance programs are associated with glycated hemoglobin A1c (HbA1c) levels among middle-aged and older US adults.
Design, Setting, And Participants: This cohort study used data from the National Health and Nutrition Examination Survey (NHANES) linked with US Department of Housing and Urban Development records of rental assistance participation.
Malaria and other apicomplexan-caused diseases affect millions of humans, agricultural animals, and pets. Cell traversal is a common feature used by multiple apicomplexan parasites to migrate through host cells and can be exploited to develop therapeutics against these deadly parasites. Here, we provide insights into the mechanism of the Cell-traversal protein for ookinetes and sporozoites (CelTOS), a conserved cell-traversal protein in apicomplexan parasites and malaria vaccine candidate.
View Article and Find Full Text PDFThe authors examine the experiences of informal housing providers, defined as those who provide housing and shelter to family, friends, and acquaintances in the context of a severe affordable rental housing crisis. Forty-five semistructured interviews were conducted with informal housing providers in and around New Haven, Connecticut, in 2021. The data describe the critical role informal housing providers play in addressing gaps in the housing safety net.
View Article and Find Full Text PDFOsteoblasts in vivo form an epithelial-like layer with tight junctions between cells. Bone formation involves mineral transport into the matrix and acid transport to balance pH levels. To study the importance of the pH gradient in vitro, we used Transwell inserts composed of polyethylene terephthalate (PET) membranes with 0.
View Article and Find Full Text PDFAlmost half of renters in the United States are rent-burdened, meaning that they pay more than 30% of their income toward housing costs. Rental assistance through programs administered by the U.S.
View Article and Find Full Text PDFHousing is central to health equity, and mass incarceration is an important but understudied aspect of housing vulnerability and health inequity. One way in which housing can be linked to health and health inequity is through ontological security. Ontological security, or a sense of feeling at home, is comprised of constancy, daily routines, privacy, and a basic security that enables the development of one's identity.
View Article and Find Full Text PDFOsteocalcin is a bone matrix protein that acts like a hormone when it reaches the blood, and has different effects in mice and humans.
View Article and Find Full Text PDFThe study purpose is to comprehensively measure landlord-related forced moves (inclusive of, but not restricted to, legal eviction), and to examine whether landlord-related forced moves is associated with HIV risk. Baseline survey data was collected between 2017 and 2018 among 360 low-income participants in New Haven, Connecticut. We used multivariable logistic regression analyses to examine associations between landlord-related forced moves and HIV sexual risk outcomes.
View Article and Find Full Text PDFThree physiologically mineralizing tissues - teeth, cartilage and bone - have critical common elements and important evolutionary relationships. Phylogenetically the most ancient densely mineralized tissue is teeth. In jawless fishes without skeletons, tooth formation included epithelial transport of phosphates, a process echoed later in bone physiology.
View Article and Find Full Text PDFHealth researchers increasingly recognize the influence of spatial stigma, or negative reputation of place, as a social determinant of health. Drawing from a New Haven-based cohort study (n = 251), we assessed the relationships between spatial stigma, self-rated health, and psychological distress using generalized estimating equation models. Adjusting for neighborhood-level poverty and racial composition, those who perceived living in spatially stigmatized neighborhoods were significantly more likely to report severe psychological distress compared to those that did not perceive their neighborhoods to be stigmatized (B = 1.
View Article and Find Full Text PDFChemical investigation of the Mediterranean Sea sponge, , collected off the Tel Aviv coast, yielded eight new bromopyrrole metabolites, agesamine C (), dioroidamide A (), slagenin D (), (-)-monobromoagelaspongin (), (-)-11-deoxymonobromoagelaspongin (), (-)-11--methylmonobromoagelaspongin (), -dispacamide (), and pyrrolosine (), along with 18 known bromopyrrole alkaloids and a known bromotyrosine derivative. The structures of the new metabolites were elucidated by analysis of the spectroscopic and spectrometric data, including 1D and 2D NMR, ECD, and high-resolution mass spectrometry. The sponge extract exhibited antimicrobial activity against pathogenic and environmental bacteria, and quorum sensing inhibitory activity (QSI) against .
View Article and Find Full Text PDFRental assistance, in the form of vouchers and project-based subsidized housing, is a primary source of affordable housing for low-income Americans, given a growing and severe shortage of private-market rental units. However, due to supply constraints, fewer than one in four eligible households receive this kind of assistance. In this paper, we examine associations between receipt of rental assistance and self-rated health among a sample of 400 low-income adults in one U.
View Article and Find Full Text PDFTo quantify variation in the restrictiveness of local public housing authority policies related to the admission and eviction of people with criminal justice histories. We conducted content analysis of housing authority policy documents for US cities with a population of 100 000 or more (n = 152). Factor analysis identified policy provisions to create a restrictiveness score (range = 0-8).
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