Publications by authors named "Schleich C"

There is a growing recognition of the influence of both genetic and ecological context in shaping different cognitive traits. The hippocampal region is identified as a critical area for memory and learning in mammals, susceptible to modification by environmental influences. Although previous studies have identified the effects of various factors on cognitive parameters during early development, comparatively few research was conducted on wild species to analyze the role of natural environmental stimuli in the formation of spatial learning and memory abilities.

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One of the main selection pressures to which animals are exposed in nature is predation, which affects a wide variety of biological traits. When the mother experiences this stressor during pregnancy and/or lactation, behavioral and physiological responses may be triggered in the offspring as well. Thus, in order to broaden and deepen knowledge on the transgenerational effects of predation stress, we evaluated how maternal stress experienced during pregnancy and/or lactation affects the spatial abilities of progeny at the onset of adulthood in the subterranean rodent Ctenomys talarum.

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Background: In diagnosing rotator cuff tears (RCTs), magnetic resonance imaging (MRI) is the imaging modality of choice, and its accuracy is improving constantly.

Purpose: To evaluate the diagnostic performance of a high-resolution 3D double-echo steady-state (DESS) sequence with radial and paracoronal 3-T MRI regarding the grading of RCTs in correlation with conventional 2D MRI and arthroscopic findings.

Material And Methods: We retrospectively compared arthroscopic findings of RCTs with preoperative MRI, including conventional 2D sequences and radial and paracoronal DESS images in 20 patients.

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Introduction: Posttraumatic MRI of ACL tears show a high prevalence of bone bruise (BB) without macroscopic proof of chondral damage. Controversial results are described concerning the association between BB and outcome after ACL tear. Aim of this study is to evaluate the influence of distribution, severity and volume of BB in isolated ACL injuries on function, quality of life and muscle strength following ACL reconstruction (ACLR).

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  • * This study investigated the effect of treatment with methotrexate combined with adalimumab versus methotrexate alone on cartilage health over 24 weeks in early rheumatoid arthritis patients.
  • * Results showed a significant increase in dGEMRIC levels in the combination therapy group after 12 and 24 weeks, suggesting improved cartilage composition, whereas the methotrexate-only group did not show significant changes.
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Background: Femoroacetabular impingement (FAI) syndrome is an established pre-osteoarthritic condition. Diagnosis is based on both clinical and radiographic parameters. An abnormal manually calculated alpha angle in magnetic resonance imaging (MRI) is traditionally utilized to diagnose abnormal femoral head-neck offset.

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  • Elite rowers face heightened risk for back injuries due to repetitive loading; this study investigates how their intervertebral disks compare to nonrowers using MRI imaging.
  • The hypothesis suggests that asymptomatic elite rowers would show unique IVD alterations, indicated by lower T2* values on magnetic resonance imaging.
  • Results confirmed that rowers had significantly lower T2* values and higher IVD damage grades compared to controls, suggesting potential early degeneration despite being asymptomatic.
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Aim: Plantar enthesophyte is a common degenerative disorder. Surgical and medical treatment options are associated with either poor outcome or high percentage of relapse. Observations have indicated a beneficial effect of radiation therapy.

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Objectives: As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).

Design: Prospective case-control study.

Methods: Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.

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  • This study focuses on improving the diagnosis of wrist injuries by using real-time MRI instead of traditional static MRI, which can't detect dynamic instability.
  • Researchers developed an automatic technique utilizing convolutional neural networks (CNNs) to analyze wrist movement and measure specific gaps between bones during motion.
  • The results showed strong accuracy compared to manual methods, and the technique successfully identified increased gap widths in a patient with a known wrist ligament injury, suggesting it could enhance diagnosis in clinical settings.
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Lumbar intervertebral disc (IVD) degeneration is characterized by structural and compositional changes. This study aimed to assess the glycosaminoglycan (GAG) content of IVDs of patients with adolescent idiopathic scoliosis (AIS) and healthy controls using GAG chemical exchange saturation transfer (gagCEST) imaging. Ten AIS patients (mean age 18.

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Using glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) magnetic resonance imaging (MRI), this study comparatively evaluated the GAG contents of lumbar intervertebral disks (IVDs) of patients with non-specific low back pain (nsLBP), radiculopathy, and asymptomatic volunteers to elucidate the association of clinical manifestation and compositional correlate. A total of 18 patients (mean age 57.5 ± 22.

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  • A study was conducted to investigate the biochemical changes in cartilage among patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using a technique called delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC).
  • The research involved 17 PsA patients and 20 RA patients, and while dGEMRIC values were similar between the two groups, the proximal interphalangeal (PIP) joints showed lower values compared to metacarpophalangeal (MCP) joints in both groups.
  • The findings indicate that the molecular composition of cartilage in PsA and RA patients is comparable, suggesting that advanced imaging techniques like dGEMRIC can be valuable for understanding and monitoring
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Purpose: Reports on heterogenous groups of patients have indicated that pedicle screw insertion guided by navigation (PIN) leads to, for the patient, higher doses of radiation compared with pedicle screw insertion guided by fluoroscopy (PIF). This would be a major concern, especially in paediatric deformity correction.

Methods: After a power analysis (aiming at > 0.

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Background: To evaluate whether a simplified (s) version of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS), sPsAMRIS, is a potential tool for therapy monitoring in psoriatic arthritis (PsA).

Methods: Seventeen patients with active psoriatic arthritis (PsA) underwent magnetic resonance imaging (MRI) at 3 T of the clinically dominant hand at baseline and after 6 months. Scoring was performed by two musculoskeletal radiologists in terms of the PsAMRIS and sPsAMRIS, which is a simplified version with reduced item numbers based on prior evaluation of responsiveness to change by standardized response means (SRMs).

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Even though cartilage loss is a known feature of psoriatic arthritis (PsA), research is sparse on its role in the pathogenesis of PsA and its potential use for disease detection and monitoring. Using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and dynamic contrast-enhanced MRI (DCE MRI), research has shown that early cartilage loss is strongly associated with synovial inflammation in rheumatoid arthritis (RA). The aim of this study was to determine if acute inflammation is associated with early cartilage loss in small finger joints of patients with PsA.

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Background: To compare the glycosaminoglycan (GAG) content of lumbar intervertebral disks (IVDs) of patients with ankylosing spondylitis (AS) and healthy volunteers and to investigate the association of GAG depletion and disease-related clinical and imaging features.

Methods: Lumbar spines of 50 AS patients (mean age 50 ± 10.5 years) and 30 age-matched volunteers were studied with 3-T magnetic resonance imaging (MRI) and conventional radiographs (CR).

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Background: Because of overlapping phenotypical presentations, the diagnostic differentiation of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) remains challenging. Thus, this study aimed to examine the diagnostic value of distinct imaging features obtained by high-resolution 3-T MRI for the diagnostic differentiation.

Materials And Methods: Seventeen patients with PsA and 28 patients with RA were imaged at high resolution using 3-T MRI scanners and a dedicated 16-channel hand coil.

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Objective: To establish and optimize a stable 3 Tesla (T) glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging protocol for assessing the articular cartilage of the tibiotalar joint in healthy volunteers and patients after a sustained injury to the ankle.

Methods: Using Bloch-McConnell simulations, we optimized the sequence protocol for a 3 T MRI scanner for maximum gagCEST effect size within a clinically feasible time frame of less than 07:30 min. This protocol was then used to analyze the gagCEST effect of the articular cartilage of the tibiotalar joint of 17 healthy volunteers and five patients with osteochondral lesions of the talus following ankle trauma.

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Background: Patients with a lumbar disc herniation (LDH) without high-grade neurological deficit (PWN) are usually treated non-operatively. If non-operative treatment is not successful, a postponed surgical treatment is performed. Postponed surgery is reported to show later improvement of pain and health-related quality of life and later return to work than early surgery.

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Objective: To measure sodium relaxation times and concentrations in human wrists on a clinical magnetic resonance imaging (MRI) scanner with a density-adapted radial sequence.

Materials And Methods: Sodium MRI of human wrists was conducted on a 3T MR system using a dual-tuned H/Na surface coil. We performed two studies with 10 volunteers each investigating either sodium T (study 1) or sodium T* (study 2) relaxation times in the radiocarpal joint (RCJ) and midcarpal joint (MCJ).

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Background: Even though cartilage loss is a known feature of psoriatic arthritis (PsA), little is known about its role in the pathogenesis of PsA. Using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) as a non-invasive marker of the tissue's proteoglycan content, such early (i.e.

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Background: It is presently unknown if lumbar lordosis (LL) might be applied to monitor low back pain (LBP) in patients with lumbar disc herniation (LDH). There is presently only conflicting data that does not show a correlation of LL with LBP: Previous studies do either include chronic LBP or do not consider that each patient has an individual value of LL that cannot be compared to other patients.

Methods: Power analysis: At least 32 patients had to be enrolled in the study.

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Purpose: To assess radiocarpal articular cartilage after distal radius fracture, with and without intra-articular extension, compared with healthy controls using multiparametric, nonenhanced magnetic resonance imaging (MRI).

Methods: In this prospective study, multiparametric MRI of the radiocarpal articular cartilage was performed in 26 participants (16 males and 10 females; mean age, 39.5 ± 14.

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