Publications by authors named "Schlegel P"
Anti-CD19 chimeric antigen receptor T cells (CAR) are a well-established treatment option for children and young adults suffering from relapsed/refractory B-lineage acute lymphoblastic leukemia. Bridging therapy is used to control disease prior to start of lymphodepletion before CAR infusion and thereby improve efficacy of CAR therapy. However, the effect of different bridging strategies on outcome, side effects and response to CAR therapy is still poorly understood.
View Article and Find Full Text PDFBackground: The incorporation of anti-GD2 antibodies such as ch14.18/SP2/0 into the multimodal treatment of high-risk neuroblastoma (HR-NB) patients has improved their outcomes. As studies assessing the long-term outcomes, long-term sequelae, and health-related quality of life (HRQoL) of this treatment are limited, this retrospective analysis aimed to explore these.
View Article and Find Full Text PDFAtrial Secondary Tricuspid Regurgitation: Insights Into the EuroTR Registry.
JACC Cardiovasc Interv
December 2024
Article Synopsis
- Atrial secondary tricuspid regurgitation (A-STR) is a subtype of secondary tricuspid regurgitation (STR) that is often treated with transcatheter tricuspid valve edge-to-edge repair (T-TEER), showing distinct patient characteristics and treatment outcomes.
- A study involving 641 patients revealed that 31% had A-STR, which was linked to better heart function, a higher presence of atrial fibrillation, and more effective TR reduction post-procedure compared to nonatrial STR patients.
- A-STR patients experienced improved survival rates and lower symptomatic burdens after treatment; only 38% remained symptomatic (NYHA class ≥III) after 2 years, compared to 46
Article Synopsis
- Stability is essential for using recombinant proteins in therapeutics and biotechnology, and deep learning methods like ProteinMPNN can help design and stabilize proteins.
- Despite these advancements, conventional designs still struggle to outperform the stability of natural proteins, particularly those from hyperthermophiles with unique amino acid compositions.
- The new model, HyperMPNN, effectively captures this unique composition and shows promise for designing highly thermostable proteins, achieving stability at much higher temperatures than previously possible.
Aims: Conventional parameters of right ventricular (RV) function are load-dependent and therefore do not accurately reflect contractility in patients with relevant tricuspid regurgitation (TR). RV adaptability to load has been characterized using the Dandel's index in patients with heart failure, but its prognostic value in patients undergoing tricuspid transcatheter edge-to-edge repair (T-TEER) has not been investigated so far.
Methods And Results: From the EuroTR registry (2019 to 2022), patients with complete datasets and a minimum of 2-years of follow-up were included.
Article Synopsis
- Treosulfan is an important treatment in allogeneic haematopoietic stem cell transplantation (allo-HSCT) for children, offering lower toxicity than traditional drugs.
- Researchers studied the effects of treosulfan on 83 pediatric patients to see how it impacts survival, graft failure, and graft-versus-host disease.
- The results showed no significant correlation between treosulfan exposure and clinical outcomes or toxicity, indicating that standardized dosing is effective for pediatric allo-HSCT.
Article Synopsis
- The study examined the effects of pulmonary hypertension (PH) on patients receiving transcatheter tricuspid valve edge-to-edge repair (T-TEER), focusing on survival rates and heart failure hospitalization outcomes.
- Results showed that higher systolic pulmonary artery pressure (sPAP) was linked to increased risks of death or hospitalization within two years, with a notable threshold of sPAP > 46 mmHg identifying those at greater risk.
- However, both the severity of heart failure symptoms and tricuspid regurgitation improved after T-TEER, regardless of whether patients had pre- or postcapillary PH.
Article Synopsis
- The study explores the complex networks of neurons in the brain, highlighting their similarities to artificial networks and how these connections influence perception and behavior.* -
- Researchers completed the first comprehensive wiring diagram of an adult fly's brain, consisting of over 130,000 neurons, enabling analysis of its statistical properties and structural organization.* -
- Findings reveal that the fly brain has a "rich-club" organization with a significant number of highly connected neurons, and the data can be accessed through the FlyWire Codex for further research on neural activity and brain structure.*
Article Synopsis
- Neuroscience aims to create a causal model of the nervous system, and recent research on the fly connectome maps the synaptic connections between neurons but lacks details on their signaling strength in real conditions.
- A new integrated approach combines experimental data from optogenetic perturbations with statistical methods to estimate the causal relationships in the fly brain, referred to as the 'effectome'.
- The findings suggest that the fly’s brain dynamics are primarily governed by small, independent circuits of neurons, making it feasible to develop a causal model for its brain activity.
Article Synopsis
- The research focuses on the fruit fly Drosophila melanogaster as a crucial model in neuroscience, aided by extensive resources like the FlyWire whole-brain connectome and a hierarchical annotation of neuron classes and types.
- The study reveals 8,453 annotated cell types, with 4,581 being newly identified, highlighting the complexity of the fly brain and emphasizing the difficulty in reidentifying some hemibrain cell types in FlyWire.
- A new definition of cell type is proposed based on cell similarities across different brains, and the study illustrates findings related to neuron connectivity, structural stability, and a consensus atlas for the fly brain's neuroanatomy, supporting future comparative studies.
Article Synopsis
- - The assembly of the Drosophila melanogaster brain connectome, featuring over 125,000 neurons and 50 million synaptic connections, serves as a framework to study sensory processing across the brain.
- - A computational model simulating the fly's brain was created to investigate the neural circuits involved in feeding and grooming behaviors, accurately predicting neuron responses to taste and motor activity.
- - The model also extends to mechanosensory circuits, confirming its ability to predict neuronal activation patterns and providing valuable insights into how the brain processes different sensory stimuli for behaviors.
Article Synopsis
- Researchers have created a detailed neuronal wiring diagram of the whole brain of a fruit fly (Drosophila melanogaster), mapping over 5 billion chemical synapses between more than 139,000 neurons, to better understand brain function.
- The study includes detailed annotations about various cell types, nerve pathways, and neurotransmitter identities, and the data is freely available for other researchers to use and explore.
- By analyzing synaptic pathways and connections, the project helps illustrate how neural structures relate to sensorimotor behaviors, paving the way for similar studies in other species.
Pig manure with high copper (Cu) and zinc (Zn) concentration is applied to the soil, and these trace minerals can accumulate in the topsoil and decrease its fertility. Thus, adjusting concentrations of Cu and Zn in pig diets below current maximum allowance can prevent this risk. Reduction of dietary concentrations of Cu and Zn reduces their faecal excretion since only a small portion is retained in the pig's body.
View Article and Find Full Text PDFHow the body interacts with the brain to perform vital life functions, such as feeding, is a fundamental issue in physiology and neuroscience. Here, we use a whole-animal scanning transmission electron microscopy volume of Drosophila to map the neuronal circuits that connect the entire enteric nervous system to the brain via the insect vagus nerve at synaptic resolution. We identify a gut-brain feedback loop in which Piezo-expressing mechanosensory neurons in the esophagus convey food passage information to a cluster of six serotonergic neurons in the brain.
View Article and Find Full Text PDFThe COVID-19 pandemic affected daily life significantly and had massive consequences for healthcare systems with tremendous regional differences. This retrospective study aimed to investigate whether the pandemic and resulting societal changes impacted the diagnosis of pediatric malignancies in a distinct region. Pediatric cancer cases in Bavaria (2016-2021) and SARS-CoV-2 proceedings during the peak phase of the pandemic (2020-2021) were retrospectively analyzed.
View Article and Find Full Text PDFObjective: Sex differences in response to trauma and physiologic stressors have been identified in numerous organ systems but have not yet been defined in the larynx. The objective of this study was to develop an endoscopic vocal fold injury model in rabbits and to compare structural and functional outcomes between male and female subjects.
Study Design: Basic science study.
Background: Transcatheter edge-to-edge repair for severe tricuspid regurgitation (TR) is a new treatment option (t-TEER). Data on optimal antithrombotic therapy after t-TEER in patients with an indication for anticoagulation are scarce and evidence-based guideline recommendations are lacking. We sought to investigate efficacy and safety of novel oral anticoagulation (NOAC) and vitamin-K-antagonists (VKA) in patients undergoing t-TEER.
View Article and Find Full Text PDFSkeleton bones, distinguished by trabecular and cortical bone tissue content, exhibit varied growth and composition, in response to modified dietary calcium and phosphorus levels. The study investigated how gilts adapt their individual bone and bone region mineralisation kinetics in response to changing intake of Ca and P. A total of 24 gilts were fed according to a two-phase (Depletion (D) 60-95 and Repletion (R) 95-140 kg BW, respectively).
View Article and Find Full Text PDFArticle Synopsis
- Targeting acute myeloid leukemia (AML) with CAR-T cells is complex due to the widespread expression of AML antigens in healthy cells and the variability between different patients and even within the same patient's tumor cells.
- Single-cell analysis of 30 pediatric AML samples highlighted CD33, CD38, CD371, IL1RAP, and CD123 as key antigens, underscoring the need for multiple targeting strategies.
- The study introduces a modular Adapter CAR platform that allows for flexible and effective targeting of these antigens, showing that combining targets can lead to better treatment outcomes in heterogeneous AML populations.