Publications by authors named "Schlager O"

Article Synopsis
  • - The European Society of Cardiology (ESC) has released new guidelines that combine recommendations for peripheral arterial disease (PAD) and aortic diseases into one document for the first time.
  • - These guidelines promote a holistic view of the arterial vascular system, emphasizing the importance of considering the entire circulatory system for patients dealing with vascular diseases.
  • - The focus is on a multidisciplinary, patient-centered approach, particularly highlighting exercise training, management of chronic wounds, and the importance of risk assessment for aortic hereditary diseases.
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Background: Timely and economic provision of revascularisation procedures is a major healthcare need. We aimed to examine the safety and efficacy of daycase-based lower extremity endovascular revascularisation procedures in patients with peripheral artery disease.

Methods: In this systematic review and meta-analysis, we searched MEDLINE and Embase for studies from Jan 01, 2000 through Apr 01, 2024 reporting complications of lower limb endovascular revascularisation procedures with same-day discharge.

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Article Synopsis
  • Venous thromboembolism (VTE) can lead to long-term complications, prompting a study to evaluate the relationship between initial clinical characteristics at diagnosis and functional limitations at 3 and 12 months post-diagnosis.
  • The study involved 307 patients (mostly middle-aged), where assessments showed improvements in functional status over time, but scores remained below pre-VTE levels.
  • Female sex, higher body mass index, older age, and pre-existing health conditions were identified as significant factors predicting ongoing functional limitations after VTE.
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Endovascular interventions and diagnostic examinations using iodinated contrast media (ICM) are standard of care in current vascular medicine. Although ICM use is generally considered safe, it may be associated with adverse reactions, vary from minor disturbances to rare, but severe life-threatening complications. This position paper of European Society of Vascular Medicine integrates current knowledge and summarizes the key information related to the use of intravascular ICM, serving as recommendation on prevention and management of acute, late, and very late adverse reactions.

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Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views of experts and propose clinical practice recommendations on the possible applications of telemedicine in vascular medicine. A clinical guidance group proposed a set of 67 clinical practice recommendations based on the synthesis of current evidence and expert opinion.

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: We aimed to study the long-term safety and efficacy of oblique venous stents for post-thrombotic syndrome (PTS) with iliac vein compression. : In the multinational, prospective, single-arm TOPOS study, PTS patients scheduled for endovascular therapy with the sinus-Obliquus stent and optional distal extension with the sinus-Venous or sinus-XL Flex stent were enrolled at eight European vascular centres between October 2016 and December 2020. The primary outcome was primary stent patency at 24 months, and secondary outcomes included the clinical course of PTS (Villalta score, revised Venous Clinical Severity Score [rVCSS], Visual Analog Scale [VAS] of pain), quality of life changes (Chronic Venous Insufficiency Quality of Life Questionnaire, CIVIQ-20), and device-related complications.

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Article Synopsis
  • Guidelines worldwide endorse exercise as a key treatment for patients with lower extremity peripheral artery disease (PAD).
  • Structured exercise programs yield the best outcomes, and this paper aims to help establish these programs for patients with chronic PAD.
  • It discusses specific exercise protocols, assesses patient outcomes based on evidence, and addresses disparities in access to supervised programs across Europe, pointing out areas needing further research.
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  • Exercise is highly recommended globally as an essential part of managing lower extremity peripheral artery disease (PAD) to improve patient outcomes.
  • This paper aims to help clinicians create effective structured exercise programs tailored for patients with symptomatic chronic PAD, detailing various training protocols and assessment methods.
  • It also addresses the unequal access to supervised exercise programs across Europe and points out the need for more research in this area.
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Article Synopsis
  • Exercise is essential for managing lower extremity peripheral artery disease (PAD), and guidelines worldwide strongly support its use.
  • A structured exercise program is crucial for achieving the best results in patients with symptomatic chronic PAD, with various training protocols outlined.
  • The document also addresses disparities in access to supervised exercise programs in Europe and identifies areas where more research is needed.
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Background: Data on walking impairment during the acute phase of deep vein thrombosis (DVT) are limited.

Objectives: This study aimed to assess the degree of walking impairment in patients with acute DVT, with a particular focus on the relation to the DVT's anatomical location.

Methods: Patients with sonographically confirmed DVT were eligible for inclusion in this cohort study.

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  • A 33-year-old man with lupus membranous nephropathy experienced painful leg swelling and acute kidney injury due to extensive thrombosis in significant venous structures, including both renal veins and the inferior vena cava.
  • Initial treatment with pharmacomechanical thrombolysis was ineffective, but catheter-based mechanical thrombectomy successfully cleared the thrombus and improved the patient’s condition.
  • Despite a recurrent thrombosis after one week, further treatment adjustments led to another thrombectomy, resulting in sustained improvement and preservation of kidney function, highlighting the importance of combining catheter-based procedures with targeted medical therapy.
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Background: For primary Raynaud phenomenon (PRP), an otherwise unexplained vasospastic disposition is assumed. To test the hypothesis of an additional involvement of distinct ultrastructural microvascular alterations, we compared the nailfold capillary pattern of patients with PRP and healthy controls.

Methods: A total of 120 patients with PRP (with a median duration of vasospastic symptoms of 60 [IQR: 3-120] months) were compared against 125 controls.

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Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammatory pathways also contributing to pro-coagulability and a prothrombotic state.

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Introduction: Radial access is the standard of care for nearly all cardiac catheterization procedures. It improves patient satisfaction, reduces the length of stay, and is associated with fewer complications. However, few devices and tools are available for the treatment of peripheral arterial disease via a transradial approach (TRA).

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Purpose: To determine the diagnostic accuracy of preinterventional imaging modalities in patients being evaluated for iliocaval venous recanalization and stent placement.

Methods: Consecutive patients with iliocaval postthrombotic obstructions or nonthrombotic iliac vein lesions (NIVL), who were scheduled for recanalization, underwent duplex ultrasound (DUS), magnetic resonance venography (MRV), multiplanar venography (MPV), and intravascular ultrasound (IVUS). The diagnostic accuracies of DUS, MRV, and MPV were analyzed using IVUS as reference.

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Venous valve aplasia (or valvular rarefication) is a rare cause of chronic venous insufficiency. In the present report, we have described the case of a 33-year-old man with severe symmetric lower leg edema and heaviness and pain in both lower legs. Duplex ultrasound demonstrated severe venous insufficiency in the superficial and deep venous system of both legs.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is reported to induce and augment autoimmune processes. Moreover, postinfectious effects of coronavirus disease 2019 (COVID-19) are still poorly understood and often resemble symptoms of the acute infection phase. A patient with swollen extremities was presented to the Department of Angiology at the Medical University of Vienna with complaints of muscle and joint pain, paresthesia, and arterial hypertension with intense headache.

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Objective: To characterise associations between individual nailfold capillary aberrations with autoantibodies in a cross-sectional study on children and adults with Raynaud's phenomenon (RP).

Methods: Consecutive children and adults with RP and without previously known connective tissue disease (CTD) systemically underwent nailfold capillaroscopy and laboratory tests for the presence of antinuclear antibodies (ANA). The prevalence of individual nailfold capillary aberrations and ANA was assessed, and the associations between individual nailfold capillary aberrations and ANA were analysed separately in children and adolescents.

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Background: A large proportion of patients experience functional limitations after an acute episode of venous thromboembolism (VTE). Recently, the post-VTE functional status (PVFS) scale was proposed to capture these limitations. We performed a prospective cohort study to validate this scale.

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Aims: Chronic limb-threatening ischaemia (CLTI) entails dismal outcomes and is an absolute indication to lower extremity revascularization (LER) whenever possible. Antithrombotic therapy is here crucial, but available evidence on best strategies (choice of drugs, combinations, duration) is scarce. We conducted a European internet-based survey on physicians' use of antithrombotic therapy after revascularization for CLTI, under the aegis of the ESC Working Group on Aorta and Peripheral Vascular Disease in collaboration with other European scientific societies involved in CLTI management and agreeing to send the survey to their affiliates.

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Purpose: The purpose of this study was to report the closure of iliac arteriovenous fistulas associated with a post-thrombotic iliac vein occlusion by iliac venous stent recanalization.

Case Report: An 80-year-old woman presented with a worsening painful swelling of her left leg after an iliofemoral deep vein thrombosis 6 months ago. Duplex ultrasound and magnetic resonance venography revealed a post-thrombotic obstruction of her iliac veins as well as several arteriovenous fistulas between branches of her left external and internal iliac arteries and adjacent diseased venous segments.

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