Histologic evaluation of wound healing in experimental intestinal anastomoses: effects of antineoplastic agents.

Histologic evaluation of intestinal wound healing with and without cytostatics was performed in 36 rats. Variables were the relative position of the wound edges in mucosa and muscularis, necrosis, exudate, granulation tissue, granulocytes, macrophages, fibroblasts, restoration of the mucosal epithelium, and repair of the muscularis propria. The relative position of the wound edges in the mucosa and the muscularis in the initial phase of wound healing depended on technique but appeared to improve in the later phases of wound healing.

Morphometric analysis of the effects of antineoplastic drugs on mucosa of normal ileum and ileal anastomoses in rats.

Antineoplastic agents affect the healing of intestinal anastomoses. They often induce anorexia and diarrhea, possibly caused by morphological changes in the small intestinal mucosa. These changes were evaluated in the rat ileum.

[Pathological anatomy in The Netherlands showing new ways].

In the early nineteenth century microscopical examination gained a lasting place in medicine, due especially to support by a more dynamic way of thinking in pathology. Morbid anatomy discovered new ways of examination which were reflected in the illustrations. In the first 70 volumes of the Nederlandsch Tijdschrift voor Geneeskunde the artist still played an important part in representing microscopical findings; it was only recently that this part was definitely terminated.

Neutrophil function and lipid peroxidation in a rat model of multiple organ failure.

Multiple organ failure (MOF) was induced by sterile intraperitoneal inoculation of zymosan in the rat. This results in a typical triphasic illness with maximal clinical signs at Days 2 and 14. In this study, granulocyte superoxide production (unstimulated and phorbol myristic acid stimulated) was studied as well as lipid peroxidation (TBAR) in plasma, liver, and lung tissue.

[Gastric polyps and their relations with gastric carcinoma].

In 31 of 33 patients with polyps of the stomach who underwent gastroscopy and x-ray examination the polyps could be diagnosed roentgenologically. 11 patients had multiple polyps, which were in 8 cases hyperplastic polyps, in 3 "other polyps", whereas in 20 patients with solitary polyps 11 cases showed hyperplastic, in 5 cases adenomatous and in 4 cases "other" polyps. After x-ray analysis it can be stated that in our cases the premalignant adenomatous polyp always occurred solitary.

Multiple-organ failure and sepsis without bacteria. An experimental model.

Multiple-organ failure is generally attributed to bacterial infection, although a correlation with positive blood cultures is not consistently found. Consequently, we studied the effects of a local nonbacterial inflammatory stimulus on distant organ functions and metabolism. Wistar rats were inoculated intraperitoneally with zymosan.

Acute generalized microvascular injury by activated complement and hypoxia: the basis of the adult respiratory distress syndrome and multiple organ failure?

It has been suggested that generalized endothelial damage and permeability changes, induced by prolonged activation of the complement system and ensuing release of lysosomal enzymes, prostaglandins and toxic oxygen products, underlie the genesis of the Adult Respiratory Distress Syndrome (ARDS) and Multiple Organ Failure (MOF). The effects in New Zealand white rabbits were investigated of a 4 h infusion of activated complement and its combination with a short hypoxic episode on respiratory function, leukocyte count, platelet count and morphology of the lungs, heart, liver, kidney and spleen. Prolonged activation of the complement system induced hyperventilation with respiratory alkalosis and hypocapnia, depletion of granulocytes (PMN), and a variable accumulation PMN in the capillaries of all organs examined, in combination with interstitial, and, in the liver, cellular oedema.

Histological features of wound repair: a comparison between experimental ileal and colonic anastomoses.

Various histological parameters of wound repair have been studied in intestinal anastomoses in the rabbit in order to compare the healing processes in ileum and colon. The sequentional appearance of granulocytes, macrophages and fibroblasts has been studied from 3 h to 7 days after operation. Also, degree of necrosis, formation of capillaries and mucosal repair were analysed semi-quantitatively.

Loss of collagen from experimental intestinal anastomoses: early events.

Collagen lysis, which always occurs to some extent in the wound area, is thought to be the underlying cause for breakdown of intestinal anastomoses. Therefore, we have studied the loss of collagen around ileal and colonic anastomoses in New Zealand White rabbits during the first 48 hr after operation. In the ileum, significant lysis of collagen in the anastomotic area, as represented by a decreased level of hydroxyproline, occurs from 12 hr postoperatively onward.

Comparison of saphir infrared coagulation and YAG-laser in the surgery of parenchymatous organs: an experimental study.

In an experimental study the efficiency of infrared coagulation and the neodymium-yttrium-aluminium and garnet laser (YAG-laser) were compared in operations on the liver, spleen and kidney in the dog. In surgery of the liver, both the YAG-laser and infrared coagulation gave good results. In surgery of the spleen, results with infrared coagulation were excellent, allowing extensive transections and partial resections.

Tumores rari et inusitati. Adenoid cystic carcinoma of the oesophagus: report of a case not responding to combination chemotherapy.

A case of a 62-year-old man with an adenoid cystic carcinoma of the oesophagus with liver metastases is described. The patient was treated with adriamycin, cisplatin and bleomycin. This combination chemotherapy failed to induce a remission.

[Double and multiple carcinomas of the colon (author's transl)].

Double or multiple carcinomas of the colon represent approximately 4% of all colon carcinomas. They may arise spontaneously or occur as a result of some predisposing disease. It is necessary to distinguish between double or multiple carcinomas arising synchronously or in sequence.