Congenital dyserythropoietic anemia type I (CDA I): molecular genetics, clinical appearance, and prognosis based on long-term observation.

Congenital dyserythropoietic anemia type I (CDA I) is a rare autosomal recessive disorder with ineffective erythropoiesis and iron overloading. More than 100 cases have been described, but with the exception of a report on a large Bedouin tribe, these reports include only small numbers of cases, and no data on the lifetime evolution of the disease are available. Since 1967, we have been able to follow 21 cases from 19 families for up to 37 years.

Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82.

Purpose: To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity.

Patients And Methods: Selection criteria was as follows: stage pT1-3a, N+ or N-, M0, less than 72 years of age. Eligible patients were randomized to receive either CMF (cyclophosphamide 100 mg/m2 orally on days 1 to 14, methotrexate 40 mg/m2 intravenously (I.

[May-Hegglin anomaly: further studies on thrombocyte dysfunction].

The May-Hegglin anomaly is an extremely rare, autosomal dominant inherited disorder characterized by alterations in white cells and in blood platelets. The granulocytes show basophilic inclusion bodies of no clinical importance. Usually moderate thrombocytopenia with variable platelet size, including giant platelets, is also found.

[Malignant non-Hodgkin lymphoma of the stomach (author's transl)].

Between 1970 and 1978 467 malignant non-Hodgkin lymphomas were newly registered by the St. Gallen-Appenzell cancer registry. Among these 23 (4.

[Primary malignant lymphomas of the gastrointestial system].

In a retrospective analysis of 25 cases of primary non-Hodgkin's lymphoma of the gastrointestinal tract, tumors with diffuse histologic pattern predominated. Among the lymphomas of the small and large bowel there was an increased percentage of tumors of lympho-plasmocytoid type. The course of gastric lymphomas is less favourable than that of intestinal lymphomas.

Proliferation activity and bacteriostatic potential of human blood monocytes, macrophages in pleural effusions, ascites, and of alveolar macrophages.

Human blood monocytes, macrophages from pleural effusions, ascites, and alveolar macrophages obtained by bronchopulmonary lavage were investigated. The proliferative activity of these cells was determined by the 3H-thymidine labeling index in vitro (3H-TDR L.I.

[Proliferative activity and bacteriostatic capacity of human alveolar macrophages (proceedings)].

Human alveolar macrophages were collected by bronchopulmonary lavage and their proliferation activity and bacteriostatic capacity determined in vitro. Compared with blood monocytes the alveolar macrophages show a higher degree of differentiation with a very high bacteriostatic capacity and no proliferation acitivity. There were no major differences between alveolar macrophages from healthy individuals, heavy smokers and patients with bronchogenic cancer.