A partially debonded rigid elliptical inclusion with a liquid slit inclusion occupying the debonded portion.

We derive a closed-form solution to the plane strain problem of a partially debonded rigid elliptical inclusion in which the debonded portion is filled with a liquid slit inclusion when the infinite isotropic elastic matrix is subjected to uniform remote in-plane stresses. The original boundary value problem is reduced to a Riemann-Hilbert problem with discontinuous coefficients, and its analytical solution is derived. By imposing the incompressibility condition of the liquid slit inclusion and balance of moment on a circular disk of infinite radius, we obtain a set of two coupled linear algebraic equations for the two unknowns characterizing the internal uniform hydrostatic tension within the liquid slit inclusion and the rigid body rotation of the rigid elliptical inclusion.

Phase II randomized trial comparing metronomic anthracycline-containing chemotherapy versus standard schedule in untreated HER2 negative advanced breast cancer: activity and quality of life results of the GOIM 21003 trial.

Background: Optimizing chemotherapy to achieve disease and symptoms control is a noteworthy purpose in advanced breast cancer (ABC). We reported the activity and quality of life of a phase II study, comparing metronomic regimen with standard schedule as first line chemotherapy for ABC.

Methods: Patients with HER2 negative ABC were randomized to non-pegylated liposomal doxorubicin (NPLD, 60 mg/m2 every 3 weeks) and cyclophosphamide (CTX, 600 mg/m2 every 3 weeks) (Arm A) or NPLD (20 mg/m2 day, on day 1, 8 and 15 every 4 weeks) and metronomic daily oral CTX 50 mg (ARM B).

Interaction between an edge dislocation and a circular incompressible liquid inclusion.

We use Muskhelishvili's complex variable formulation to study the interaction problem associated with a circular incompressible liquid inclusion embedded in an infinite isotropic elastic matrix subjected to the action of an edge dislocation at an arbitrary position. A closed-form solution to the problem is derived largely with the aid of analytic continuation. We obtain, in explicit form, expressions for the internal uniform hydrostatic stresses, nonuniform strains and nonuniform rigid body rotation within the liquid inclusion; the hoop stress along the liquid-solid interface on the matrix side and the image force acting on the edge dislocation.

Evaluation of Biofilm Production and Antifungal Susceptibility to Fluconazole in Clinical Isolates of spp. in Both Planktonic and Biofilm Form.

spp. are an important opportunistic pathogen that can represent a possible cause of severe infections, especially in immunocompromised individuals. The clinical impact of spp.

Uniformity of anti-plane stresses inside a nonlinear elastic elliptical or parabolic inhomogeneity.

We study the anti-plane strain problem associated with a -Laplacian nonlinear elastic elliptical inhomogeneity embedded in an infinite linear elastic matrix subjected to uniform remote anti-plane stresses. A full-field exact solution is derived using complex variable techniques. It is proved that the stress field inside the elliptical inhomogeneity is nevertheless uniform.

Effect of Inevitable Heat Leap on the Conversion Efficiency of Thermoelectric Generators.

Discrepancies between experimental and theoretical results in the study of thermoelectric generators (TEGs) have been a major long-standing problem in thermoelectric technology. In this Letter, we report that, besides interfacial resistance, the inevitable heat leap caused by the Peltier effect is the main factor affecting the conversion efficiency of TEGs. In fact, the heat leap is proven to have an impact of approximately 10% on the conversion efficiency of common TEGs.

Interaction between an edge dislocation and a circular elastic inhomogeneity with Steigmann-Ogden interface.

We propose an effective method for the solution of the plane problem of an edge dislocation in the vicinity of a circular inhomogeneity with Steigmann-Ogden interface. Using analytic continuation, the pair of analytic functions defined in the infinite matrix surrounding the inhomogeneity can be expressed in terms of the pair of analytic functions defined inside the circular inhomogeneity. Once the two analytic functions defined in the circular inhomogeneity are expanded in Taylor series with unknown complex coefficients, the Steigmann-Ogden interface condition can be written explicitly in complex form.

Clarification of Faber series and related applications to complex variable methods in two-dimensional elasticity.

Faber series are used extensively in the application of complex variable methods to two-dimensional elasticity theory, for example, in the mechanical analysis of composite materials where Faber series representations of complex potentials lead to convenient expressions for the corresponding displacement and stress distributions. In many cases, the use of the Faber series is combined with conformal mapping techniques which "transfer" a boundary value problem defined in the elastic body (physical plane) to a simpler problem posed in an imaginary plane characterized by the conformal mapping. In several instances in the literature, however, little attention has been paid to the domain of definition of the Faber series in the imaginary plane leading often to misunderstandings and erroneous conclusions regarding the concept and feasibility of the use of the Faber series.

An elliptical inhomogeneity under nonuniform heat flux.

We use complex variable techniques to study the decoupled two-dimensional steady-state heat conduction and thermoelastic problems associated with an elliptical elastic inhomogeneity perfectly bonded to an infinite matrix subjected to a nonuniform heat flux at infinity. Specifically, the nonuniform remote heat flux takes the form of a linear distribution. It is found that the internal temperature and thermal stresses inside the elliptical inhomogeneity are quadratic functions of the two in-plane coordinates.

Kinetics of dried blood spot-measured anti-SARS-CoV2 Spike IgG in mRNA-vaccinated healthcare workers.

Introduction: One of the major criticisms facing the research community during SARS-CoV2 pandemic was the lack of large-scale, longitudinal data on the efficacy of the SARS-CoV2 mRNA vaccines. Currently, even if COVID-19 antiviral treatments have been authorized by European Medicine Agency, prevention through approved specific vaccines is the best approach available in order to contain the ongoing pandemic.

Objectives: Here, we studied the antibody kinetic over a one-year period from vaccination with the Pfizer-BioNTech (Pfizer) vaccines and subsequent boosting with either the BioNTech or Moderna (Spikevax) vaccines in a large cohort of 8,071 healthcare workers (HCW).

Persistence of Antibody Responses to the SARS-CoV-2 in Dialysis Patients and Renal Transplant Recipients Recovered from COVID-19.

Nephropathic subjects with impaired immune responses show dramatically high infection rates of coronavirus disease 2019 (COVID-19). This work evaluated the ability to acquire and maintain protective antibodies over time in 26 hemodialysis patients and 21 kidney transplant recipients. The subjects were followed-up through quantitative determination of circulating SARS-CoV-2 S1/S2 IgG and neutralizing antibodies in the 6-month period after clinical and laboratory recovery.

Metronomic oral chemotherapy with cyclophosphamide plus capecitabine combined with trastuzumab (HEX) as first line therapy of HER-2 positive advanced breast cancer: A phase II trial of the Gruppo Oncologico Italia Meridionale (GOIM).

Background: The combination of chemotherapy plus anti HER-2 agents is the mainstay of HER-2 positive advanced breast cancer (ABC) therapy. We conducted a phase II trial testing activity and safety of trastuzumab and metronomic capecitabine/cyclophosphamide (HEX) as first-line therapy in HER-2 positive ABC.
Methods.

Factors Associated With Central Line-Associated Bloodstream Infections in a Cohort of Adult Home Parenteral Nutrition Patients.

Background: Central line-associated bloodstream infection (CLABSI) is a potentially life-threatening complication in home parenteral nutrition (HPN) patients. We investigated potential predictors of CLABSI in a cohort of adult HPN patients METHODS: Patients managed by the HPN service at the Hospital of University of Pennsylvania on January 1, 2018, were included and followed through June 30, 2019, using existing medical records to collect demographic and clinical data. CLABSIs were adjudicated prospectively by infectious disease experts.

Multicenter Evaluation of the C6 Lyme ELISA Kit for the Diagnosis of Lyme Disease.

Lyme disease (LD), caused by infection with , is the most common tick-borne infection in many regions of Eurasia. Antibody detection is the most frequently used laboratory test, favoring a two-step serodiagnostic algorithm; immunoenzymatic detection of antibodies to C6 has been shown to perform similarly to a standard two-step workflow. The aim of this study was the performance evaluation of the C6 Lyme ELISA kit compared to a standard two-step algorithm in three laboratories located in the northeastern region of Italy which cater to areas with different LD epidemiology.

Eribulin plus trastuzumab in pretreated HER2-positive advanced breast cancer patients: safety and efficacy. An Italian experience.

Background: Chemotherapy plus targeted therapy is the established treatment for human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer (BC). Limited data regarding the safety and activity of the combination of eribulin and trastuzumab (E/T) in pretreated HER2-positive advanced BC (ABC) are available. The aim of this observational, retrospective, multicenter study was to examine the tolerability and the clinical activity of E/T in this setting.

Preparing the Patient for Home Parenteral Nutrition and for a Successful Course of Therapy.

Preparing the patient for home parenteral nutrition (HPN) is a collaborative effort among many different clinicians. Identifying patients who will transition home with parenteral nutrition (PN) as early as possible allows for a thoughtful and safe approach. Communication regarding the HPN goals is critical to the patient's success, whether the requirement for PN is temporary or permanent.

Final results of a prospective study of scalp cooling in preventing chemotherapy-induced alopecia.

Alopecia is a distressing effect of cancer treatments. Our study examined efficacy and safety of scalp cooling to prevent chemotherapy-induced alopecia. Early breast cancer patients candidate to anthracycline and/or taxane were eligible.

infection in Italy: report of 3 years' evaluation along the coast of the northern Adriatic Sea.

algae are Gram-negative, nonfermentative, motile bacilli, classified in the genus in 1985. These environmental bacteria are occasionally identified in human infections, with a relatively strong association with exposure to seawater during warm seasons. This report describes a case series of 17 patients with infection correlated to in the coastal area of Romagna, Italy, from 2013 to 2016.

Comparison of 'time to detection' values between BacT/ALERT VIRTUO and BacT/ALERT 3D instruments for clinical blood culture samples.

Objectives: The early detection of bacteraemia and fungemia is of paramount importance to guide antimicrobial therapy in septic patients. In this study the 'time to detection' (TTD) value for the new blood culture system BacT/ALERT VIRTUO (VIRTUO) was evaluated in 1462 positive clinical bottles and compared with the TTD for 1601 positive clinical bottles incubated in the BacT/ALERT 3D system (BTA-3D).

Methods: The most representative microorganisms isolated from bottles incubated in both blood culture systems were divided into eight categories (in order of frequency): coagulase-negative staphylococci (CoNS), Escherichia coli, Enterobacteriaceae (other than E.

Response of extensive breast cancer skin metastases to rechallenge with trastuzumab together with low-dose chemotherapy and insulin.

Introduction: Cutaneous metastasis occurs in about 29% of breast cancer patients and has a deep impact on patient quality of life.

Methods: A 60-year-old woman with cutaneous metastases from heavily pretreated HER2-positive breast cancer received CMFVP (oral cyclophosphamide 100 mg daily; oral prednisone 12.5 mg daily for 2 weeks, then 7.

Discordance in pathology report after central pathology review: Implications for breast cancer adjuvant treatment.

Aim: Pathological predictive factors are the most important markers when selecting early breast cancer adjuvant therapy. In randomized clinical trials the variability in pathology report after central pathology review is noteworthy. We evaluated the discordance rate (DR) and inter-rater agreement between local and central histopathological report and the clinical implication on treatment decision.

Clinical Management of Patients With Parenteral Nutrition-Dependent Short Bowel Syndrome During Teduglutide Therapy.

Background: Patients with intestinal failure, who are dependent on parenteral nutrition (PN) to supplement their limited absorption of dietary nutrients, are subject to complications associated with long-term PN therapy. Medication therapy that results in improved dietary nutrient absorption may enable these patients to reduce or even become independent from PN therapy and its related complications. The glucagon-like peptide 2 (GLP-2) analogue teduglutide was approved for use in such patients by the U.

Panitumumab after progression on cetuximab in KRAS wild-type metastatic colorectal cancer patients: a single institution experience.

Aims And Background: Few data describe the activity of panitumumab after cetuximab-irinotecan-based regimen failure in patients with KRAS wild-type metastatic colorectal cancer (WT MCRC).

Methods: The aim of this study is to assess if panitumumab has some activity in this setting.

Results: We retrospectively analyzed 25 patients with KRAS WT MCRC who received panitumumab from July 2009 to January 2013 after progression on cetuximab.