ABVD in older patients with early-stage Hodgkin lymphoma treated within the German Hodgkin Study Group HD10 and HD11 trials.

Purpose: Older patients with Hodgkin lymphoma (HL) account for approximately 20% of all HL patients. ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy is regarded as standard of care in these patients. However, little is known on feasibility and efficacy of ABVD in this age group.

[Effect of chemotherapy on the survival of patients with far-advanced squamous cell carcinoma of the head and neck. A comparative matched-pair analysis of conventional therapeutic procedures with and without chemotherapy].

Forty-four patients, surgically and/or radiologically treated after primary cytostatic treatment, were compared by matched-pair analysis with a historical control group of patients who had been conventionally treated by surgery and/or radiotherapy only. Both groups were largely identical with respect of tumour localisation and classification, regional metastases, and conventional treatment. The disease-free survival and overall survival times did not differ significantly between both groups.

[Results of primary chemotherapy in 44 patients with advanced squamous cell carcinoma in the area of the head and neck].

44 patients with advanced squamous cell carcinoma of the head and neck were randomized and treated preoperatively either with arm "A": cis-DDP (3 mg/kg iv day 1) and BLM (15-20 mg iv continuously day 2-6) or arm "B": MTX (30 mg/m2 iv day 1 + 6) and VDS (3 mg/m2 iv day 2 + 7). Treatment with arm "A" was superior producing 73% complete and partial remissions (CR + PR) compared to 40% for arm "B" (p = 0,05). The number of patients with CR could be increased from 2 to 26 by surgery and/or radiotherapy.

[Results of drug therapy with cisplatin and 5-fluorouracil in squamous cell carcinoma of the head and neck region].

30 patients with advanced squamous cell carcinoma of the head and neck received initial chemotherapy with Cisplatin (100 mg/m2 i.v. day 1) and 5-Fluorouracil (1000 mg/m2 as 24-hour-infusion day 2-6).

[Indications for cytostatic therapy of recurrent cancer].

28 patients with recurrent squamous cell carcinoma of the Head and Neck underwent consecutive chemotherapy. Two different regimens were used: cis-platinum plus bleomycin and methotrexate plus vindesine. The former seemed to produce a better response to the latter, but neither differed in its influence on survival.

[Cytostatic therapy of advanced squamous cell carcinoma of the head and neck. A randomized study comparing cis-dichlorodiammineplatinum(II) and bleomycin with methotrexate and vindesine].

79 patients were randomized and treated either with cis-DDP 33 mg/kg i.v. day 1 and BLM 15 mg/m2 i.

[2d interim evaluation of a chemotherapy study on patients with squamous cell carcinomas of the head-neck area. A comparison of 2 therapy regimens: cis-diamminedichloroplatinum (II) and bleomycin versus methotrexate and vindesine].

52 patients with epidermoid cancer of the head and neck region were either treated with cis-DDP and bleomycin (arm A) or with methotrexate and vindesine (arm B). In case of resistance patients were further treated with the alternative regimen (A leads to B or B leads to A). Treatment results are superior in arm A.

[Chemotherapy of esophageal and cardial carcinomas].

In esophageal carcinoma chemotherapeutic agents such as bleomycin, methotrexate, cisplatin, VP-16, and vindesine produce remission rates up to 30%. Combination chemotherapy resulting in remission rates of about 50% has so far been insufficiently tested. Selection of patients with favorable prognostic criteria is mandatory for optimal treatment results.

Experimental hyperthyroidism IV. Myocardial muscle mechanics and oxygen consumption in euand hyperthyroidism.

Myocardial mechanics and oxygen consumption were studied in right ventricular papillary muscles taken from cats pretreated with cristalline L-thyroxine (1 mg/kg/day, i.p.) 8-18 days prior to the examination.

Experimental hyperthyroidism III: Contractile responses to propranolol of the intact heart and of the isolated ventricular myocardium.

The effect of propranolol on cardiac mechanics and haemodynamics was examined on isolated papillary muscle as well as in situ in the closed thorax in euthyroid and hyperthyroid cats. Under propranolol there occurred on isolated papillary muscle significant decreases of muscle contraction, contraction velocity, isometric tension rise velocity and load and velocity values of simultaneously determined force-velocity relations. The 50% decrease of the values found was demonstrable at ca.

Experimental hyperthyroidism II. Mechanics of contraction and relaxation of isolated ventricular myocardium.

The effect of experimental hyperthyroidism on myocardial mechanics was examined on isolated ventricular myocardium (right ventricular papillary muscle) of cats. 1. Isotonic muscle contraction and isometric tension development were largely unchanged compared with euthyroidism.

Experimental hyperthyroidism I. Hemodynamics and contractility in situ.

The influence of experimental hyperthyroidism (intraperitoneal injection of crystalline L-thyroxine 1 mg/kg/day, 8-18 days) on cardiac mechanics in contractility in situ were studied in 30 hyperthyroid cats and compared with an euthyroid control group (n equals 30). 1. In hyperthyroidism left ventricular weight was considerably increased.

Myocardial mechanics and oxygen consumption in experimental hyperthyroidism.

Myocardial mechanics and oxygen consumption were studied in right ventricular papillary muscles taken from cats (N = 15), pretreated with cristaline L-thyroxine (1 mg/kg/day, i.p.) 8-18 days prior to the examination.