Exophthalmos, global luxation, rapid weight gain: differential diagnosis.

Exophthalmos is an uncommon finding in the clinical setting; exophthalmos with global luxation is distinctly rare. Although the differential diagnosis of exophthalmos can be extensive, the most common causes are thyroid dysfunction and orbital neoplasia. We recently encountered a patient with exophthalmos and global luxation, the onset of which coincided with a weight gain of 45.