Publications by authors named "Schelbert H"
Article Synopsis
- This study looked at how inflammation affects heart health in people with rheumatoid arthritis (RA), focusing on something called myocardial flow reserve (MFR), which is important for heart function.! -
- Researchers examined 66 patients with RA who started a new treatment and checked their heart blood flow before and after the treatment, finding that nearly half had issues with their heart's small blood vessels.! -
- Although there was no improvement in heart flow after treatment, they saw some links between lower inflammation markers and a tiny drop in one specific marker related to heart health.
Article Synopsis
- Angina and dyspnea in patients with normal coronary arteries present a diagnostic challenge, with many possibly suffering from coronary microvascular dysfunction (CMD) rather than traditional coronary artery disease.
- Positron emission tomography (PET) is used to measure myocardial blood flow (MBF) and reserve (MFR), which helps noninvasively detect CMD, leading to better understanding of patients' symptoms.
- A consensus document is in development to standardize the diagnosis and reporting for CMD to improve treatment decisions and patient outcomes, involving experts from around the world.
A 3-year-old, previously healthy girl started having clusters of seizures, not responsive to multiple antiepileptic medications. High-dose prednisone and intravenous immunoglobulin could partially control the seizures. Lumbar puncture and CT were normal.
View Article and Find Full Text PDFA 71-year-old man underwent 18F-FDG and 68Ga-FAPI-46 PET/CT for initial staging prior to surgery of a squamous cell carcinoma of the lower esophagus under the prospective study NCT04147494. Both scans showed increased uptake in the mid and distal esophagus without evidence of metastatic disease. A soft tissue right infrascapular mass with mild 18F-FDG and moderate 68Ga-FAPI-46 uptake was incidentally found.
View Article and Find Full Text PDFBackground: To evaluate the cerebral metabolism in patients with heart failure (HF).
Methods: One hundred and two HF patients were prospectively enrolled, who underwent gated Tc-sestamibi single photon emission computed tomography (SPECT)/CT, cardiac and cerebral F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Fifteen healthy volunteers served as controls.
Article Synopsis
- - The study aimed to assess the safety and effectiveness of F-labeled flurpiridaz for PET imaging in healthy individuals during both rest and stress conditions (either exercise or adenosine).
- - Twelve subjects received varying doses of flurpiridaz, and researchers recorded radiation exposure and biodistribution over five hours, concluding that heart walls received the highest radiation dose.
- - Results indicated flurpiridaz is both safe and well-tolerated, making it a viable option for clinical use in myocardial perfusion imaging without significant adverse effects.
Article Synopsis
- The editors of the Journal reflect on current relevant topics, including prognostication, paradigm shifts, and the handling of serial testing data.
- They discuss ischemia-guided therapy options like fractional flow reserve and various imaging techniques using Rubidium-82, N-13 ammonia, and F-18 Flurpiridaz.
- Additionally, they explore issues related to radiation exposure, camera system differences, and the benefits of hybrid imaging techniques in diagnostic practices.
Background: The incidence of myocardial inflammation in patients with unexplained cardiomyopathy referred for ventricular arrhythmias (VAs) is unknown.
Objective: The purpose of this study was to report fasting positron emission tomographic (PET) scan findings in consecutive patients referred with unexplained cardiomyopathy and VA.
Methods: Fluorine-18 fluoro-2-deoxyglucose (18-FDG) PET/computed tomographic (CT) scans with a >16-hour fasting protocol were prospectively ordered for patients referred for VA and unexplained cardiomyopathy (ejection fraction <55%).
Article Synopsis
- * Our approach involved collaboration across various scientific fields to gather necessary applications and supporting data.
- * This method successfully transitioned three (18)F-fluoro-arabinofuranosylcytosine (FAC) analog PET probes into phase 1 clinical trials, meeting FDA regulations efficiently.
Angiographic severity of coronary artery stenosis has historically been the primary guide to revascularization or medical management of coronary artery disease. However, physiologic severity defined by coronary pressure and/or flow has resurged into clinical prominence as a potential, fundamental change from anatomically to physiologically guided management. This review addresses clinical coronary physiology-pressure and flow-as clinical tools for treating patients.
View Article and Find Full Text PDF