Semantic Integration Demands Modulate Large-Scale Network Interactions in the Brain.

The ability to integrate semantic information into the context of a sentence is essential for human communication. Several studies have shown that the predictability of a final keyword based on the sentence context influences semantic integration on the behavioral, neurophysiological, and neural level. However, the architecture of the underlying network interactions for semantic integration across the lifespan remains unclear.

Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial.

Background: Rhabdomyosarcoma and other soft tissue sarcomas (STS) with high-risk features are still associated with an unsatisfactory outcome. We evaluated the efficacy of oral maintenance therapy added at the end of standard therapy in patients with high-risk rhabdomyosarcoma and STS.

Methods: CWS-2007-HR was a multicentre, open-label, randomised controlled, phase 3 trial done at 87 centers in 5 countries.

Breaking barriers: The impact of telemedicine on improving soft tissue and bone tumor management in Armenia.

Purpose: Musculoskeletal sarcomas are a rare group of malignant neoplasms, accounting for approximately 12 % of all malignant neoplasms among children. Childhood cancer outcomes vary between developed and developing countries due to financial and educational inequalities. Telemedicine programs have a huge impact on the quality of cancer care, helping to optimize resources for better cancer care in a resource-limited setting.

Inhibition of angiogenesis and regenerative lung growth in mice through adiponectin-VEGF/VEGFR2 signaling.

Introduction: Obesity is associated with impairment of wound healing and tissue regeneration. Angiogenesis, the formation of new blood capillaries, plays a key role in regenerative lung growth after unilateral pneumonectomy (PNX). We have reported that obesity inhibits angiogenesis.

The Other Site of Rhabdomyosarcoma.

Background: Rhabdomyosarcoma (RMS) is a rare malignant soft tissue sarcoma (STS), accounting for almost 50% of pediatric STSs. Due to its heterogeneity, RMS presents challenges in diagnosis and treatment, with prognosis varying depending on multiple factors. Tumors localized in the other site (OTH)-including the paraspinal, perianal, thoracic, abdominal, pelvic, and perineal regions-are generally classified as unfavorable.

Correlated topological flat bands in rhombohedral graphite.

Flat bands and nontrivial topological physics are two important topics of condensed matter physics. With a unique stacking configuration analogous to the Su-Schrieffer-Heeger model, rhombohedral graphite (RG) is a potential candidate for realizing both flat bands and nontrivial topological physics. Here, we report experimental evidence of topological flat bands (TFBs) on the surface of bulk RG, which are topologically protected by bulk helical Dirac nodal lines via the bulk-boundary correspondence.

Nimodipine Used with Vincristine: Protects Schwann Cells and Neuronal Cells from Vincristine-Induced Cell Death but Increases Tumor Cell Susceptibility.

The chemotherapeutic agent vincristine is commonly used for a variety of hematologic cancers, as well as solid tumors of the head and neck, bronchial carcinoma, as part of the procarbazine, lomustine and vincristine (PCV) regimen, for glioma. Damage to nerve tissue (neuropathy) is often dose-limiting and restricts treatment. Nimodipine is a calcium antagonist that has also shown neuroprotective properties in preliminary studies.

Enhancing the Reactivity of an Aromatic cyclo-P Ligand via Electrophilic Activation.

Electrophilic activation of the aromatic cyclo-P ligand in [Cp*Fe(η-P)] is demonstrated to drastically enhance its reactivity towards weak nucleophiles. Unprecedented functionalized, contracted as well as complexly aggregated polyphosphorus compounds are accessed utilizing [Cp*Fe(η-PMe)][OTf] (A), highlighting the great potential of this underexplored mode of reactivity. Addition of carbenes to A affords novel 1,2- or 1,1-difunctionalized cyclo-P complexes [Cp*Fe(η-P(1-L)(2-Me)][OTf] (L=IDipp (1), CAAC (2), IPr (3 b)) and [Cp*Fe(η-P(1-IPr)(1-Me)][OTf] (3 a).

Synthesis of Sb: Crafting a Homoatomic Antimony Nanotorus.

Pure-element cyclic molecules have garnered extensive attention owing to their intriguing structures and promising applications. Among these, carbon-based cyclic molecules such as []carbon (C, = 10-26) and carbon nanotori have ignited significant interest in both experimental and theoretical investigations. However, systematic investigations of analogous cyclic counterparts of heavier main-group elements are limited, with only a few known by theoretical studies.

High-Temperature Solid-State Post-Synthetic Modification of Highly Luminescent Cu(I) Metallacycles toward New Luminescent Thermic Tracers.

A new luminescent Cu(I) tetrametallic metallacycle B is reported that features very rare semi-bridging aqua ligands. When heated markedly above room temperature, this compound undergoes a post-synthetic transformation in the solid-state, affording the new luminescent metallacycle C. Thermogravimetric analysis, IR spectroscopy and single-crystal X-ray diffraction reveal that this alteration preserves the gross tetrametallic macrocycle structure, but is caused by the release of the coordinated water molecules with the concomitant formation of cuprophilic interactions.

Synthesis of bismuthanyl-substituted monomeric triel hydrides.

The syntheses and characterizations of the first bismuthanylborane monomers stabilized only by a donor in D·BHBi(SiMe) (D = DMAP 1a, IDipp 1b, IMe1c; DMAP = 4-dimethylaminopyridine, IDipp = 1,3-bis(2,6-diisopropylphenyl)-imidazolin-2-ylidene, IMe = 1,3,4,5-tetramethylimidazol-2-ylidene) are presented. All compounds were synthesized by salt metathesis reactions between D·BHI and KBi(SiMe)(THF) and represent some of the extremely rare compounds featuring a 2c-2e B-Bi bond in a molecular compound. The products display high sensitivity towards air and light and slowly decompose in solution even at -80 °C.

German translation and cross-cultural adaptation of the Vestibular Schwannoma Quality of Life Index (VSQOL).

Background: Vestibular schwannomas (VSs) are benign tumors of the vestibulocochlear nerve that often cause significant neurological and functional impairment. Patient-reported outcomes, including quality of life (QoL), are essential for understanding the overall impact of VS and its treatment. This study aimed to translate and culturally adapt the Vestibular Schwannoma Quality of Life (VSQOL) Index into German to expand its relevance to German-speaking populations.

Evaluating the Impact of Coaching Through the Transition to Residency.

Background: Coaching has been proposed to support the transition to residency. Clarifying its impact will help define its value and best use.

Objective: To explore the experiences of residents working with coaches through the residency transition.

Potential of Mixed Dipnictogen Molybdenum Complexes in the Self-Assembly of Thallium Coordination Compounds.

The coordination chemistry of the homo- and heterodipnictogen tetrahedrane complexes [{CpMo(CO)}(μ,η-EE')] (E, E' = P, As, Sb) () toward Tl[BArF] ([BArF] = [B(3,5-CH(CF))]) was studied. Controlled by the used tetrahedranes , and thus depending on the respective pnictogen atoms, the monomers [Tl(η-)][BArF] ([]) and [Tl(η-)][BArF] ([]), the double substituted [Tl(η-)][BArF] ([]) or the even higher aggregated compounds [Tl(η-)(μ,η-)(μ,η-)][BArF] ([]), [Tl(η-)(μ,η-)] [BArF] ([]) and [Tl(η-)(μ,η-)][BArF] ([]) were obtained. Utilization of [BArF] promises additional stabilization of Tl via η-coordination of two of its aryl rings as found in compounds [], [] and [].

Homo- and heterobimetallic transition metal cluster derived from [Cp*Fe(η-E)] (E = P, As) - unprecedented structural motifs of the resulting polypnictogen ligands.

A general synthetic procedure to neutral homo- and heterobimetallic cage compounds exhibiting various structural motifs of the polypnictogen ligands starting from [Cp*Fe(η-E)] (E = P (1), As (2); Cp* = CMe) is reported. The impact of the implemented transition metal precursors {Cp'''M} (M = Cr, Mn, Fe, Ni; Cp''' = 1,2,4-BuCH) emphasises the variability of the isolated complexes exhibiting a broad variety of structural motifs of the pnictogen ligands. Spectroscopic, crystallographic, and theoretical investigations provide insight into the structure of the partially unprecedented polypnictogen ligands.

Extension and Fusion of Cyclic Polyantimony Units.

The synthesis and characterization of a series of polyantimony anionic clusters are reported. The products [(NbCp)Sb], [MSb] (M = Ru/Fe), and [MSb] (M = Ru/Fe) were isolated as either K(18-crown-6) or K([2.2.

Synthesis and Characterization of Novel Cobalt Carbonyl Phosphorus and Arsenic Clusters.

Phosphorus- and arsenic-containing cobalt clusters are an interesting class of compounds that continue to provide new structures with captivating bonding patterns. Although the first members of this family were reported 45 years ago, the number of such species is still limited within the broad family of transition metal complexes bearing pnictogen atoms. Herein, we present the reaction of Co(CO) as a cobalt source with a number of phosphorus- and arsenic-containing compounds under variable reaction conditions.

Psychological factors and long-term tinnitus handicap in vestibular schwannoma patients after retrosigmoid microsurgery - a cross-sectional study.

Objective: This study aimed to investigate the connection between psychological factors and postoperative tinnitus in vestibular schwannoma (VS) patients following retrosigmoid microsurgery.

Design: Cross-sectional study.

Study Sample: Ninety-three VS patients participated, completing questionnaires on demographics, tinnitus severity (THI-12), personality traits (TIPI-G), dizziness impact (DHI), perceived health benefits (GBI), somatisation tendencies (SOMS-2), and psychological distress (HADS-D).

Supramolecular compounds assembled from the heteroleptic tetrahedral complex [{CpMo(CO)}(μ,η-AsSb)] and metal salts.

The reaction of the tetrahedral complex [{CpMo(CO)}(μ,η-AsSb)] with Cu and Ag salts is presented which gives unprecedented neutral and cationic supramolecular aggregates featuring mixed As/Sb-donor molecules as ligands/linkers between metal ions.

A Ruthenophosphanorcaradiene as a Synthon for an Ambiphilic Metallophosphinidene.

Reaction of the ruthenium carbene complex Cp*(IPr)RuCl () (IPr = 1,3-bis(Dipp)imidazol-2-ylidene; Dipp = 2,6-diisopropylphenyl) with sodium phosphaethynolate (NaOCP) led to intramolecular dearomatization of one of the Dipp substituents on the Ru-bound carbene to afford a Ru-bound phosphanorcaradiene, . Computations by DFT reveal a transition state characterized by a concerted process whereby CO migrates to the Ru center as the P atom adds to the π system of the aryl group. The phosphanorcaradiene possesses ambiphilic properties and reacts with both nucleophilic and electrophilic substrates, resulting in rearomatization of the ligand aryl group with net P atom transfer to give several unusual metal-bound, P-containing main-group moieties.

Perceived Health Benefits in Vestibular Schwannoma Patients with Long-Term Postoperative Headache: Insights from Personality Traits and Pain Coping-A Cross-Sectional Study.

Postoperative headaches (POHs) following retrosigmoid microsurgery for vestibular schwannoma (VS) can significantly impact patients' perceived health benefits (PHBs). In this cross-sectional observational study, 101 VS patients were investigated. For the assessment of pain, the Rostock Headache Compendium (RoKoKo) and the German pain processing questionnaire (FESV) were used.

Electrophilic Functionalization of a Hexaphosphabenzene Ligand in [(Cp*Mo)(μ,η-P)].

The electrophilic functionalization of the triple-decker sandwich complex [{Cp*Mo}(μ,η-P)] (A) and its mono-oxidized counterpart [{Cp*Mo}(μ,η-P)][SbF] (B) with reactive main-group electrophiles as well as radical scavengers is shown to be a reliable method for the selective functionalization of the hexaphosphabenzene ligand. Depending on the electrophile used, the regioselectivity of the functionalization can be adjusted. Using group 16 electrophiles, the trisubstituted compounds [{Cp*Mo}{(μ,η-P)(μ,η-1,3-(SePh)-2-Br-P)}][TEF] (1), [{Cp*Mo}(μ,η-P)(μ,η-1,2,3-(EPh)-P)][SbF] (E=S (2), Se (3)) as well as the side product [{Cp*Mo}(μ,η-P)(μ,η-P(SPh))][SbF] (4) are obtained.

Twistronics of Kekulé Graphene: Honeycomb and Kagome Flat Bands.

Kekulé-O order in graphene, which has recently been realized experimentally, induces Dirac electron masses on the order of m∼100  meV. We show that twisted bilayer graphene in which one or both layers have Kekulé-O order exhibits nontrivial flat electronic bands on honeycomb and kagome lattices. When only one layer has Kekulé-O order, there is a parameter regime for which the lowest four bands at charge neutrality form an isolated two-orbital honeycomb lattice model with two flat bands.