Procedural efficiency is enhanced combining the pentaspline pulsed field ablation catheter with three-dimensional electroanatomical mapping system for pulmonary vein isolation.

Background: Pulsed field ablation (PFA) offers a safe, non-thermal alternative for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). Currently, the pentaspline PFA-system relies heavily on fluoroscopy for catheter manipulation, which poses challenges due to the complexity of left atrium anatomy. Incorporating three-dimensional electroanatomical mapping (3D-EAM) could improve procedural efficiency reducing dependency on fluoroscopy guidance.

Epistemic domination by data extraction: questioning the use of biometrics and mobile phone data analysis in asylum procedures.

In a growing number of destination countries state authorities have started to use various digital devices such as analysis of data captured from mobile phones to verify asylum seekers' claimed country of origin. This move has prompted some critics to claim that asylum decision-making is increasingly delegated to machines. Based on fieldwork at a reception centre in Germany, this paper mobilises insights from science and technology studies (STS) to develop a framework that allows for more nuanced analyses and modes of critiques of the digitisation of asylum procedures.

miRNA profiling of esophageal adenocarcinoma using transcriptome analysis.

Esophageal adenocarcinoma (EAC) occurs following a series of histological changes through epithelial-mesenchymal transition (EMT). A variable expression of normal and aberrant genes in the tissue can contribute to the development of EAC through the activation or inhibition of critical molecular signaling pathways. Gene expression is regulated by various regulatory factors, including transcription factors and microRNAs (miRs).

Order-Invariant Two-Photon Quantum Correlations in PT-Symmetric Interferometers.

Multiphoton correlations in linear photonic quantum networks are governed by matrix permanents. Yet, surprisingly few systematic properties of these crucial algebraic objects are known. As such, predicting the overall multiphoton behavior of a network from its individual building blocks typically defies intuition.

[Pulsed Field Ablation shows promise - Experiences from the first 100 patients in Sweden].

Pulmonary vein isolation (PVI) of symptomatic atrial fibrillation is an effective method of maintaining sinus rhythm. Radiofrequency ablation and cryotechnology have been used for this purpose for many years. One disadvantage of these methods is the risk of serious complications such as pulmonary vein stenosis, phrenic nerve palsy and atrio-oesophageal fistula.

Perspectives on weak interactions in complex materials at different length scales.

Nanocomposite materials consist of nanometer-sized quantum objects such as atoms, molecules, voids or nanoparticles embedded in a host material. These quantum objects can be exploited as a super-structure, which can be designed to create material properties targeted for specific applications. For electromagnetism, such targeted properties include field enhancements around the bandgap of a semiconductor used for solar cells, directional decay in topological insulators, high kinetic inductance in superconducting circuits, and many more.

Digitisation and Sovereignty in Humanitarian Space: Technologies, Territories and Tensions.

Debates are ongoing on the limits of - and possibilities for - sovereignty in the digital era. While most observers spotlight the implications of the Internet, cryptocurrencies, artificial intelligence/machine learning and advanced data analytics for the sovereignty of nation states, a critical yet under examined question concerns what digital innovations mean for authority, power and control in the humanitarian sphere in which different rules, values and expectations are thought to apply. This forum brings together practitioners and scholars to explore both conceptually and empirically how digitisation and datafication in aid are (re)shaping notions of sovereign power in humanitarian space.

Intermediate-Range Casimir-Polder Interaction Probed by High-Order Slow Atom Diffraction.

At nanometer separation, the dominant interaction between an atom and a material surface is the fluctuation-induced Casimir-Polder potential. We demonstrate that slow atoms crossing a silicon nitride transmission nanograting are a remarkably sensitive probe for that potential. A 15% difference between nonretarded (van der Waals) and retarded Casimir-Polder potentials is discernible at distances smaller than 51 nm.

Reconstruction of nanoscale particles from single-shot wide-angle free-electron-laser diffraction patterns with physics-informed neural networks.

Single-shot wide-angle diffraction imaging is a widely used method to investigate the structure of noncrystallizing objects such as nanoclusters, large proteins, or even viruses. Its main advantage is that information about the three-dimensional structure of the object is already contained in a single image. This makes it useful for the reconstruction of fragile and nonreproducible particles without the need for tomographic measurements.

Asymmetric Rydberg blockade of giant excitons in Cuprous Oxide.

The ability to generate and control strong long-range interactions via highly excited electronic states has been the foundation for recent breakthroughs in a host of areas, from atomic and molecular physics to quantum optics and technology. Rydberg excitons provide a promising solid-state realization of such highly excited states, for which record-breaking orbital sizes of up to a micrometer have indeed been observed in cuprous oxide semiconductors. Here, we demonstrate the generation and control of strong exciton interactions in this material by optically producing two distinct quantum states of Rydberg excitons.

Doing statistics, enacting the nation: The performative powers of categories.

It has been widely acknowledged in debates about nationalism and ethnicity that identity categories used for classifying people along the lines of culture, race, and ethnicity help to enact, that is, bring into being, the collective identities they name. However, we know little about how categories acquire their performative powers. The contribution of this paper is twofold: first, it proposes a conceptual framework based on concepts and insights from science and technology studies for investigating the performative powers of statistical identity categories and possibly also other domains.

Cryoablation as standard treatment of atrial flutter: a prospective, 2-center study (CASTAF).

Background: Cryoablation (CRYO) of cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) has been shown to be non-inferior to radiofrequency ablation (RF) in terms of ablation success and is associated with less pain. However, procedural time has been significantly longer with CRYO compared to RF. A possible explanation for this could be that operators had less experience with CRYO than with RF.

Rydberg Excitons in the Presence of an Ultralow-Density Electron-Hole Plasma.

We study the Rydberg exciton absorption of Cu_{2}O in the presence of free carriers injected by above-band-gap illumination. Already at plasma densities ρ_{EH} below one hundredth electron-hole pair per μm^{3}, exciton lines are bleached, starting from the highest observed principal quantum number, while their energies remain constant. Simultaneously, the band gap decreases by correlation effects with the plasma.

Signatures of Quantum Coherences in Rydberg Excitons.

Coherent optical control of individual particles has been demonstrated both for atoms and semiconductor quantum dots. Here we demonstrate the emergence of quantum coherent effects in semiconductor Rydberg excitons in bulk Cu_{2}O. Because of the spectral proximity between two adjacent Rydberg exciton states, a single-frequency laser may pump both resonances with little dissipation from the detuning.

Heterozygous inactivating CaSR mutations causing neonatal hyperparathyroidism: function, inheritance and phenotype.

Background: Homozygous inactivating mutations of the calcium-sensing receptor (CaSR) lead to neonatal severe hyperparathyroidism (NSHPT), whereas heterozygous inactivating mutations result in familial hypocalciuric hypercalcemia (FHH). It is unknown why in some cases heterozygous CaSR mutations cause neonatal hyperparathyroidism (NHPT) clinically similar to NSHPT but with only moderately elevated serum calcium.

Methods: A literature survey was conducted to identify patients with heterozygous CaSR mutations and NHPT.

Friction forces on atoms after acceleration.

The aim of this paper is to revisit the calculation of atom-surface quantum friction in the quantum field theory formulation put forward by Barton (2010 New J. Phys. 12 113045).

Giant Rydberg excitons in the copper oxide Cu2O.

A highly excited atom having an electron that has moved into a level with large principal quantum number is a hydrogen-like object, termed a Rydberg atom. The giant size of Rydberg atoms leads to huge interaction effects. Monitoring these interactions has provided insights into atomic and molecular physics on the single-quantum level.

Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells.

Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition. Additionally, cellular stress is accompanied by endoplasmic reticulum-stress which induces an unfolded protein response.

Carbon ion radiotherapy of human lung cancer attenuates HIF-1 signaling and acts with considerably enhanced therapeutic efficiency.

Carbon ion irradiation is an emerging therapeutic option for various tumor entities. Radiation resistance of solid tumors toward photon irradiation is caused by attenuation of DNA damage in less oxygenated tumor areas and by increased hypoxia-inducible factor (HIF)-1 signaling. Carbon ion irradiation acts independently of oxygen; however, the role of HIF-1 is unclear.

Comparing impedance cardiography and echocardiography in the assessment of reduced left ventricular systolic function.

Background: An early and accurate diagnosis of chronic heart failure is a big challenge for a general practitioner. Assessment of left ventricular function is essential for the diagnosis of heart failure and the prognosis. A gold standard for identifying left ventricular function is echocardiography.

[Are diurnal and nocturnal intraocular pressure measurements over 48 h justified?].

Purpose: Diurnal intraocular pressure (IOP) measurements are recommended in cases of visual field deterioration in glaucoma patients. In this study the rationale of 24 h versus 48 h IOP measurements was investigated.

Patients And Methods: Mean IOP and maximum IOP values were obtained in 80 patients over a period of 48 h.

Self-esteem fluctuations and cardiac vagal control in everyday life.

It has been proposed that self-esteem buffers threat-responding. The same effect is ascribed to the vagus nerve, which is a primary nerve of the parasympathetic nervous system. Consequently, it has been suggested that self-esteem and cardiac vagal tone are interconnected on a trait, as well as on a state, level.

Temperature-independent Casimir-Polder forces despite large thermal photon numbers.

We demonstrate that Casimir-Polder potentials can be entirely independent of temperature even when allowing for the relevant thermal photon numbers to become large. This statement holds for potentials that are due to low-energy transitions of a molecule placed near a plane metal surface whose plasma frequency is much larger than any atomic resonance frequencies. For a molecule in an energy eigenstate, the temperature independence is a consequence of strong cancellations between nonresonant potential components and those due to evanescent waves.

Mutations in the WTX-gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers.

Background: Genetically, colorectal cancers (CRCs) can be subdivided into tumors with chromosomal instability (CIN) or microsatellite instability (MSI). In both types of CRCs genes that are involved in the degradation of beta-CATENIN are frequently mutated. Whereas in CIN CRCs APC (Adenomatous Polyposis Coli) is affected in most cases, high grade MSI (MSI-H) CRCs frequently display mutations in various genes, like the APC-, AXIN2- or CTNNBI (beta-CATENIN) gene itself.