[The influence of a beta-adrenergic receptor blocking drug and a calcium antagonist on heart function in normal subjects (author's transl)].

In 13 healthy volunteers, ergometric examinations in the supine position after intake of 2 x 40 mg/d (-)-1-(tert.-butyl-amino)-3-(o-cyclopentylphenoxy)-2-propanol (penbutolol, Betapressin), a new beta-adrenergic receptor blocking substance, or 3 x 60 mg/d N-(3,3-diphenylpropyl)-alpha-methyl-phenethylamine (prenylamine, Segontin) showed no alteration of the exercise tolerance compared to controls. Also there was a significant decrease of heart rate and systolic pressure and an increase of the maximal heart volume at rest and during exercise after intake of the beta-adrenergic receptor blocking drug.

Nonlinearities in auditory-nerve fiber responses to bandlimited noise.

Discharge rate was measured as a function of spectral level for noise bursts of one bandwidth and center frequency. Such rate-level functions were measured for a number of bandwidths; either the low- or high-cutoff frequencies were set at fiber characteristic frequency (CF). Rate-level functions were also measured, simultaneously, for single tones at CF.