Chronic imipramine administration reduces apomorphine inhibitory effects.

Changes in activity of dopaminergic and serotonergic systems were assessed after acute and chronic (14 days) imipramine (10 mg/kg) administration in mice. For this purpose, biochemical and behavioural tests were performed at different intervals of time after withdrawal of treatment. Brain levels of 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, homovanillic acid and 3,4-dihydroxyphenylacetic acid were assayed by a fluorometric method.

Are polygraphic and cardiopneumographic respiratory patterns useful tools for predicting the risk for sudden infant death syndrome? A 10-year study.

Between 1974 and 1984 we have studied 204 control infants (C) comparing them with 650 SIDS siblings (SS) and 146 near-miss for SIDS (NM). These 1,000 full-term infants were recorded by day polysomnography (DPSG; n = 417), night polysomnography (NPSG; n = 257) and cardiopneumography (CPG; n = 2,600). Records were visually analyzed.

Differential effects of single and long-term amphetamine and apomorphine administrations on locomotor activity of rats.

The effects of single and long-term administration of apomorphine (AP) and amphetamine (AM) on the locomotor behaviour of rats observed in an open-field (LF), and on the locomotion stereotyped behaviour (LSB) of rats were compared in the present study. Single AP treatment did not modify LF and LSB. Single AM treatment reduced the duration of LSB 2 and 3 days after drug administration, but did not alter the LF.

[Coma in full-term newborn infants following acute fetal distress: electro-clinical evolution].

Twenty full term infants who had birth asphyxia were studied. These infants were in a comatose state for 4 to 15 days and at least 3 EEG recordings were performed during this period. Six infants recovered without sequelae and in 2 cases there were minor abnormalities.

Striatal dopamine receptor sensitivity after subchronic fencamfamine in the rat.

Dopamine (DA) receptor sensitivity was assessed in the rat striatal system following subchronic treatment with fencamfamine or saline for 7 days (10 mg/kg i.p.).

Differential biochemical and behavioral effects of single and chronic administration of amphetamine and apomorphine.

The single and repeated effects of apomorphine (AP) and amphetamine (AM) administrations were compared on rearing behaviour in an open field (RF) and on rearing stereotyped behaviour (RSB). Single AP treatment did not modify RSB while decreased the ability of low doses of AP to inhibit RF. Opposite data were observed after AM single administration.

Influence of phenoxybenzamine on the stereotyped behaviour induced by fencamfamine in rats: evidence for a qualitative alteration.

The interactions between norepinephrine (NE) and dopamine (DA) systems in mediating stereotyped behaviour induced by different doses of fencamfamine (1-30 mg/kg) were studied in male rats. Pretreatment with phenoxybenzamine (5.0 mg/kg) resulted in a significant leftward shift of the control curve for stereotypy.

Differential changes in dopaminergic receptor sensitivity induced by agonist drugs.

Mice were treated acutely or chronically with apomorphine (APO) (0.1 and 1.0 mg/kg) or L-DOPA (150 mg/kg) plus benserazide (50 mg/kg).

On the mechanism of central stimulation action of fencamfamine.

The stereotypy induced by fencamfamine (10 mg/kg i.p.) was compared in different groups of rats which had been pretreated with catecholaminergic drugs.

The urinary excretion of 5-hydroxyindoleacetic acid does not reflect brain levels of this metabolite of 5-hydroxytryptamine.

The present study was undertaken to determine if changes in the serotonergic central nervous system can be reflected by urinary 5-hydroxyindoleacetic acid (5-HIAA) levels. Cerebral, spinal and urinary levels of 5-HIAA were determined and compared in rats whose cerebral 5-HIAA concentration had been depleted by nucleus raphe dorsalis and medialis lesion or increased by L-tryptophan loading. Since no differences were observed in the urinary excretion of 5-HIAA we conclude that this parameter cannot be used to detect changes in the serotonergic central nervous system.

Comparative biochemical and behavioural effects of fencamfamine and dl-amphetamine in rats.

Fencamfamine increased locomotion, rearing and sniffing behaviours at 10 mg/kg intraperitoneal doses in rats. Amphetamine increased rearing, sniffing and locomotion behaviours at respectively higher, same and lesser magnitudes than did fencamfamine at equimolar (5 mg/kg) intraperitoneal doses in rats. Forty-five minutes after fencamfamine (10 mg/kg), the levels of homovanillic acid in the tuberculum olfactorium, nucleus accumbens and striatum, and those of dihydroxyphenylacétic acid in accumbens were increased.

[Giant intracranial arteriovenous malformation and facial lymphangioma (author's transl)].

A 28 days old boy with a lymphangioma located in the scalp of the left frontal and facial zones associated to a giant intracranial arteriovenous malformation (GAVM) is presented. Evacuation of blood was verified specially through the left lateral venous sinus.