Highlights from the family of journals.
View Article and Find Full Text PDFLineage switch (LS) refers to the immunophenotypic transformation of one leukemia lineage to another (ie, lymphoid to myeloid) with retention of baseline genetics. This phenomenon was originally observed in infants with B-lymphoblastic leukemia (B-ALL) with rearrangements following chemotherapy, but is now increasingly being observed as a form of immune escape following targeted therapies among children and adults with B-ALL with and without rearrangements. In this report, we present two cases of adolescents with B-ALL harboring rearrangements (Philadelphia-like phenotype) who developed LS to acute myeloid leukemia following CD19 targeted therapy.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFBackground: Intra-axial brain tumors persist as significant clinical challenges. Aggressive surgical resection carries risk of morbidity, and the blood-brain barrier (BBB) prevents optimal pharmacological interventions. There is a clear clinical demand for innovative and less invasive therapeutic strategies for patients, especially those that can augment established treatment protocols.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFOptimal athletic performance relies on meeting specific nutritional requirements, encompassing adequate calorie intake, macronutrient intake, and hydration. Misinformation or misconceptions about these necessities are prevalent among young athletes. This study investigated nutrition and hydration knowledge and practices among 28 male rugby union players aged 16 to 17, participating in Munster Rugby's 2023 Summer Age-Grade Development Programme, specifically the U18's Schools Squad.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDFHighlights from the family of journals.
View Article and Find Full Text PDF