Publications by authors named "Sazonova O"

Unlabelled: This study investigates the anatomical prerequisites that could contribute to the development of this condition.

Material And Methods: Using multi-slice computed tomography (MSCT), the study examined the structure and relationships of key anatomical features, including the alveolar process, sinus wall thickness, and the position of the teeth in relation to the maxillary sinus.

Results: The results revealed that the lower wall of the maxillary sinus is predominantly formed by the alveolar process, with significant variability in wall thickness, especially between the central and lateral regions.

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Biodegradation of phenol is an effective method for removing this toxicant from contaminated sites. Phenol is a toxic compound for living cells, so many bacteria degrade phenol in relatively low concentrations, up to 0.75 g L.

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Article Synopsis
  • Cytochrome CYP102A1 (P450 BM3) from Priestia megaterium is a promising candidate for directed evolution due to its unique functions and ability to hydroxylate androstanes into bioactive products.
  • The study focused on expressing a mutant form of this enzyme, CYP102A1-LG23, in Mycolicibacterium smegmatis BD, achieving successful conversion of androst-4-ene-3,17-dione into 7β-OH-AD.
  • Co-expressing the mutant enzyme with glucose dehydrogenase (GDH) led to a significant increase in hydroxylation yield, demonstrating the potential for engineered bacteria to produce valuable steroid compounds.
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The complete genome of the naphthalene- and -alkane-degrading strain sp. strain OVF7 was collected and analyzed. Clusters of genes encoding enzymes for the degradation of naphthalene and -alkanes are localized on the chromosome.

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Background: Status epilepticus (SE) is characterized by continuous course of clinical and/or electrographic epileptic seizures. There are little data on the course and outcomes of SE after resection of brain tumors.

Objective: To analyze clinical and electrographic manifestations of SE, its course and outcomes in short-term period after resection of brain tumors.

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Strains of the genus are poorly studied microorganisms. In this work, the complete genome of the naphthalene-degrading strain ULwDis3 isolated from seawater of the Gulf of Finland of the Baltic Sea was assembled. For the first time, genes encoding naphthalene cleavage pathways via salicylate and gentisate were identified in a strain of the genus .

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The impact of geographical factors, functional zoning, and biotope type on the diversity of microbial communities and chemical components in the dust of urban ecosystems was studied. Comprehensive analyses of bacterial and fungal communities, polycyclic aromatic hydrocarbons (PAHs), and metals in road and leaf dust in three urban zones of Murmansk and Moscow with contrasting anthropogenic load were conducted. We found that the structure of bacterial communities affected the functional zoning of the city, biotope type, and geographical components.

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Pollution of the environment by crude oil and oil products (represented by various types of compounds, mainly aliphatic, mono- and polyaromatic hydrocarbons) poses a global problem. The strain Pseudomonas veronii 7-41 can grow on medium-chain n-alkanes (C-C) and polycyclic aromatic hydrocarbons such as naphthalene. We performed a genetic analysis and physiological/biochemical characterization of strain 7-41 cultivated in a mineral medium with decane, naphthalene or a mixture of the hydrocarbons.

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We performed a comparative study of the total bacterial communities and communities of cultivable polycyclic aromatic hydrocarbons (PAH)-degrading bacteria in different functional zones of Moscow and Murmansk that were formed under the influence of the PAH composition in road and leaf dust. The PAHs were determined by high-performance liquid chromatography (HPLC); the bacterial communities' diversity was assessed by metabarcoding. The degraders were isolated by their direct plating on a medium with the PAHs.

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A substantial proportion of the adult United States population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI). We hypothesized that a polygenic score (PGS) may serve as a complementary tool to identify high-risk individuals. The T2D polygenic score maintained predictive utility after adjusting for family history and combining genetics with family history led to even more improved disease risk prediction.

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One of the most frequently used methods for elimination of oil pollution is the use of biological preparations based on oil-degrading microorganisms. Such microorganisms often relate to bacteria of the genus Pseudomonas. Pseudomonads are ubiquitous microorganisms that often have the ability to oxidize various pollutants, including oil hydrocarbons.

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The phylloplane is an integrated part of green infrastructure which interacts with plant health. Taxonomic characterization of the phylloplane with the aim to link it to ecosystem functioning under anthropogenic pressure is not sufficient because only active microorganisms drive biochemical processes. Activity of the phylloplane remains largely overlooked.

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In this study, we investigated antibiotic-resistant microorganisms isolated by the direct plating method from 6 playgrounds in the city of Pushchino, Moscow Region, with different types of coating: sand, soil with sand, grass and a modern playground coating made of pressed rubber crumb. According to the results of the study, sand is the cleanest type of coating, both in terms of the total count of cultivated microorganisms (8 × 10/g of substrate) and in terms of the content of resistant strains. The most contaminated both in terms of the total count of cultivated microorganisms (1.

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Unlabelled: Currently, there is a decrease in the total number of organizations for summer recreation of children in the country while the share of organizations of group II of sanitary and epidemiological well-being among them remains at a consistently high level that determines the potential risk of harm to the health of the child population. At the same time, there is an increase in the number of children with a pronounced health-improving effect. So, it becomes necessary to analyze the information content of modern criteria for assessing the effectiveness of health improvement and to search for ways to resolve the noted contradictions.

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Objective: Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study (GWAS) meta-analysis to identify genetic risk factors for HEM to date.

Design: We conducted a GWAS meta-analysis of 218 920 patients with HEM and 725 213 controls of European ancestry.

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Article Synopsis
  • * Findings: Significant risk factors for T2DM included high BMI, abdominal obesity, fasting hyperglycemia, high triglycerides, hypertension, and family history of diabetes. Secondary education, low physical activity, and cardiovascular disease history were also notable for females.
  • * Tool Development: A T2DM risk calculator was created based on simple, non-laboratory parameters like waist circumference, hypertension history, and family diabetes history, providing an effective way to identify individuals at
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Pulmonary neuroendocrine tumors (NETs) are a heterogeneous family of malignancies whose classification relies on morphology and mitotic rate, unlike extrapulmonary neuroendocrine tumors that require both mitotic rate and Ki-67. As mitotic count is proportional to Ki-67, it is crucial to understand if Ki-67 can complement the existing diagnostic guidelines, as well as discover the benefit of these two markers to unravel the biological heterogeneity. In this study, we investigated the association of mitotic rate and Ki-67 at gene- and pathway-level using transcriptomic data in lung NET malignancies.

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Introduction: Diffuse idiopathic pulmonary neuroendocrine hyperplasia (DIPNECH) is a rare condition that is likely underdiagnosed owing to the lack of established and validated diagnostic criteria. These clinical guidelines are empirical and created on the basis of a limited number of studies. This study was designed to validate the existing criteria and to identify new clinical parameters that can accurately diagnose DIPNECH.

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Introduction: Paradoxical air embolism (PAE) is a rare potentially fatal complication followed by entering of air emboli from the right cardiac chambers and pulmonary artery to large circulation circle.

Objective: To analyze five patients who underwent neurosurgical intervention complicated by PAE and early postoperative convulsive syndrome.

Material And Methods: There were five patients who developed early postoperative convulsive syndrome after previous neurosurgery in sitting position complicated by PAE.

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Pulmonary neuroendocrine neoplasms are classified by WHO as either typical or atypical carcinoids, large cell (LCNEC) or small cell (SCLC) neuroendocrine carcinoma based on mitotic count, morphology, and necrosis assessment. LCNEC with low mitotic count and sharing morphologic features with carcinoids are in a gray zone for classification and their rare prevalence and the paucity of studies precludes proper validation of the current grading system. In this study, we aim to investigate their clinicopathological and transcriptomic profiles.

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Coronary angiography is the standard imaging method for determining the site, extent, and severity of coronary artery disease. Several publications have reported discordance between the degree of coronary artery stenosis determined from post-mortem histologic evaluation and coronary angiography. While the 2-dimensional limitations of coronary angiography are well established, the determination of coronary stenosis based on histologic evaluation of passively fixed samples is also associated with significant biases.

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Nowadays new efficient methods of dental correction and modern methods of abnormal bite correction are suggested. In this regard, seems to be important to study the existence of individual anatomical variability range of the maxilla and its structures. The research has been conducted on 100 bone samples of integral and fragmented skulls from the collections of anatomy department of Kharkiv National Medical University.

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Purpose: Based on a comparative analysis of the key dispersion parametries of spray-aerosol forms of drugs Kameton from different manufacturers the most effective drug in terms of delivery to the mucous membrane of the throat was choosen.

Material And Methods: The objects of study were 5 drugs brand Kameton, produced in the form of a metered-dose spray manufacturers of 'Firm 'VIPSMED' (RF), 'Altayvitaminy' (RF), 'Samaramedprom' (RF), 'ESCO-Pharm' (Armenia) and metered-dose aerosol - of 'Pharmstandard' (RF). Measurement of the dynamic characteristics of the spray and the dispersed composition of the spray was carried out by the method of shadow photography with digital image processing using the 'POLIS' system.

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Unlabelled: Arteriovenous malformations (AVMs) are some of the most frequent congenital abnormalities of the cerebral vascular system and usually occur at a young age. Given the fact that AVMs can manifest, in addition to hemorrhages, as symptomatic epilepsy (17-40%) that occurs more often at a young age and may lead to significant disability, investigation of this pathology remains topical. Particular attention has recently been paid to the management of AVM patients without clinical signs of hemorrhage at the time of pathology diagnosis.

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