Improvement of Russian clinical guidelines and reduction of mortality in perforated ulcers.

Objective: To analyze the results of laparoscopic surgery in patients with perforated ulcers using evidence-based medicine approaches.

Material And Methods: We compared the efficacy and effectiveness of laparoscopic and open surgeries in patients with perforated ulcers. Meta-analysis of mortality after laparoscopic surgeries (randomized controlled trials) and trial sequential analysis were carried out.

Is antipsychotic augmentation associated with improved functioning in patients on clozapine?

Objective: We aimed at exploring the relationship between functional outcomes in patients on clozapine augmented with antipsychotics in treatment-resistant schizophrenia using standard outcome measures Health of Nation Outcome Scales (HoNOS) and Life Skills Profile (LSP-16).

Method: In a cross-sectional study of 83 patients on clozapine treated in a psychiatric rehabilitation hospital, the association between the primary outcome measure, LSP-16 including its subscales, and treatment with antipsychotic augmentation (AA) were analysed using linear regression.

Result: The presence of moderate-to-severe positive symptoms on the HoNOS 6 dichotomised item measure was the only statistically significant predictor of functional impairment as determined by total LSP-16 score.

Does theta burst stimulation have differential benefit for those with melancholic or non-melancholic depression?

Background: To determine if theta burst stimulation (TBS) is of preferential benefit to those with melancholic or non-melancholic depression as an adjunctive treatment for treatment resistant depression (TRD).

Methods: Fifty-two patients receiving TBS at a private psychiatric hospital participated in a naturalistic study. Four diagnostic strategies were used to assign melancholic versus non-melancholic depression subtype status.

[Prospects for development of laparoscopic surgery in the Central Federal District of the Russian Federation].

Objective: To analyze the achievements of laparoscopic surgery in the Central Federal District of Russia and outline perspective trends for further application.

Material And Methods: The study included adult patients with abdominal surgical diseases hospitalized in general surgical departments of the Central Federal District between 2014 and 2021. We analyzed the prevalence of elective and emergency laparoscopic surgeries.

[In-hospital mortality in acute abdominal diseases in the Central Federal District of Russia depending on availability of laparoscopic procedures].

Objective: To study in-hospital mortality in acute abdominal diseases in the Central Federal District and compared effectiveness of laparoscopic and open surgeries.

Material And Methods: The study was based on the previous data for 2017-2021. The odds ratio (OR) was used to assess significance of between-group differences.

[Impact of staffing on the results of treatment among surgical patients. Statistical study].

Objective: To study the influence of staffing index on the results of surgical treatment.

Material And Methods: The study was based on the data of surgical service in the Russian Federation upon 2018 (A.Sh.

[Loop colostomy as a risk factor of postoperative ileus in elective colorectal cancer surgery].

Objective: To identify risk factors of postoperative ileus (POI) in elective colorectal cancer (CRC) surgery.

Material And Methods: A non-randomized retrospective study included 220 patients who underwent elective surgery for colorectal tumors. The indication for surgery was CRC stage 0-IV in 213 (96.

[Surgical care in the Russian Federation during the pandemic - the main results of 2020].

Objective: To study the impact of the SARS-CoV-2 pandemic on surgical care in the Russian Federation.

Material And Methods: A retrospective cohort study of surgical care in state medical organizations of the Russian Federation in 2020 was conducted in comparison with 2019. The electronic database of the annual reports of the Chief surgeon of the Ministry of Health of the Russian Federation was used, which includes data from 3.

Predictors of laxative use in inpatients with schizophrenia on clozapine.

Objectives: Constipation, a clinical manifestation of gastrointestinal hypomotility, is a common and potentially serious complication of clozapine therapy, requiring laxatives for its prevention and treatment. We explored the predictive factors of the increased laxative use in inpatients receiving a long-term clozapine therapy.

Methods: In the cross-sectional study of 93 patients in a psychiatric rehabilitation hospital, we examined a four-week prevalence of laxative use and a range of demographic and clinical factors associated with the number of prescribed laxatives.

[Effectiveness of laparoscopic cholecystectomy for acute cholecystitis].

Objective: To analyze the impact of laparoscopic cholecystectomy on in-hospital and postoperative mortality in patients with acute cholecystitis.

Material And Methods: Comparative analysis was based on primary statistical data presented in public available analytical collections «Surgical care in the Russian Federation» (Revishvili A.Sh.

Predictors of functioning and clinical outcomes in inpatient with schizophrenia on clozapine augmented with antipsychotics.

Objective: We aimed at exploring predictors of improvement in clinical and functional outcomes of patients on clozapine with chronic treatment-resistant schizophrenia admitted into rehabilitation wards.

Method: In a cross-sectional study of 62 patients on clozapine augmented with oral and parenteral antipsychotics, predictors of HoNOS (Health of the Nation Outcome Scales) scores were analysed using ordinal logistic regression.

Result: Augmentation with parenteral antipsychotics was associated with lower psychotic symptom scores (OR 0.

[Modern aspects of the complex treatment of perforated gastric and duodenal ulcer].

Objective: To study the effectiveness of pharmacotherapy for perforated gastric ulcer in a surgical hospital.

Material And Methods: A retrospective analysis of the treatment of 693 patients with perforated gastric and duodenal ulcers was carried out. Laparoscopic and open surgeries were performed.

Influence of the incidence of ulcerative gastroduodenal bleeding on the effectiveness of treatment. Statistical surveillance.

Objective: To study and to justify statistically the influence of the incidence of ulcerative gastroduodenal bleeding on the results of treatment.

Material And Methods: The results of treatment of 56.233 patients with ulcerative gastroduodenal bleeding in the Central Federal district have been analyzed throughout a 5-year follow-up period.

Emotion-Oriented Coping Style Predicts Self-Harm in Response to Acute Psychiatric Hospitalization.

Psychiatric hospitalization can cause significant distress for patients. Research has shown that to cope with the stress, patients sometimes resort to self-harm. Given the paucity of research on self-harm among psychiatric inpatients, a better understanding of transdiagnostic processes as predictors of self-harm during psychiatric hospitalization is needed.

[Current trends in emergency abdominal surgery in the Russian Federation].

Objective: To analyze morbidity and factors affecting mortality in emergency abdominal surgery in the Russian Federation.

Material And Methods: The study included patients with acute abdominal diseases aged 18 years and older. All patients were hospitalized in emergency surgical care departments of 3.

[Large outpatient surgery. Are there prospects?].

Aim: To study frequency of 'hospital registry' operations in the polyclinics of the Central Federal district, to analyze previous experience of outpatient surgical care and to assess perspective directions of its development.

Material And Methods: Over 48 million people who referred to polyclinics for medical care in 17 regions of Central Federal district for 6 years (2011-2016) were studied.

Results: Mean surgical activity in the polyclinics of Central Federal district is 4.

[Surgical treatment of ulcerative pyloroduodenal stenosis].

Aim: To obtain the most reliable information about surgical treatment of ulcerative pyloroduodenal stenosis based on the methodology of evidence-based medicine.

Material And Methods: Searching platforms were elibrary, Cochrane Library and PubMed database. The probability of major systematic errors in randomized controlled trials (RCTs) was evaluated.

[Emergency surgery in Russian Federation (in Russian only)].

In the following article, we present the key trends in emergency surgical care in the Russian Federation between 2000 and 2017. The study used data from federal statistical observations and a survey of state medical institutions in 80 regions encompassing 99.3% of the country's population.

[Current directions in professional training of surgeon].

Aim: To develop 'Cadaveric Course' of operative surgery for severe combined trauma for students, surgical residents, postgraduate students of medical universities and to compare its effectiveness with other approaches.

Material And Methods: 'Cadaveric course' program of operative surgery for severe combined trauma consisted of four stages. The first stage is theoretical course (2 weeks), the second stage - students' work in cadaveric operating theatre with instructors (5 weeks), the third stage - their independent work in 'cadaveric operating theatre (10 weeks), the fourth stage - analysis of the results and their comparison with those of 5 2-year residents (control group).

[Reality and prospects of sepsis epidemiology research].

Current foreign and Russian literature for sepsis epidemiology is reviewed. There is advanced incidence of sepsis in developing countries among young people as a rule. Absent high-quality epidemiological studies lead to overdiagnosis of sepsis and increased morbidity.

[Specialist's training for laparoscopic surgery in Wet-lab educational operating theatre].

Aim: To develop system for students training in laparoscopic surgery by using of Wet-lab educational operating theatre.

Material And Methods: We have launched laparoscopic surgery teaching program for students of Ryazan State Medical University. This system includes several stages.

[Law and educational components of patient's safety in surgery].

Aim: To evaluate law and educational components of patient's safety (PS) in surgery.

Material And Methods: In order to analyze complex causes of adverse outcomes in surgery we performed an interviewing of 110 surgeons, 42 emergency physicians and 25 health care managers. The main keynote consisted in assessing law and educational components of PS.