Endometrial intraepithelial carcinoma in association with polyp: review of eight cases.

Background: The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC).

Patients And Methods: Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76 years (av.

Granulosa cell tumor with activated mTOR-HIF-1alpha-VEGF pathway.

The DNA-binding activity of hypoxia-inducible factor-1 alpha (HIF-1alpha) has been analyzed for various gynecological tumors. Among the tumors that were studied, there was a finding of a high level of DNA-binding HIF-1alpha activity, although it was limited to one case of adult type granulosa cell tumor (GCT). In this case a 60-year-old female had marked immunohistochemical expression of HIF-1alpha.