Publications by authors named "Sayuri Kokubun"
Objective: Although psychological distress is a prevalent issue among patients with amyotrophic lateral sclerosis (ALS) and can impact survival, the risk factors contributing to this distress remain insufficiently understood.
Methods: Patients with ALS who completed the Profile of Mood States (POMS) between June 2017 and March 2022 were included. Participants with moderate to severe cognitive decline were excluded, resulting in the recruitment of 121 patients.
Article Synopsis
- * Results indicated that 34 patients had DVT, with a notably higher incidence in those with Parkinson's disease (38%) compared to other conditions like ALS (2%) and MSA (5%).
- * Identified risk factors for developing DVT included being female, having Parkinson's disease, increased age, greater disease duration, and high blood pressure variability, suggesting a need for improved patient management regarding anticoagulant use.
Article Synopsis
- The study examines how medial temporal atrophy relates to different onset subtypes of amyotrophic lateral sclerosis (ALS), focusing on bulbar, upper limb, and lower limb types.
- Researchers assessed 119 ALS patients using neuroimaging and functional scales to analyze medial temporal atrophy and its progression over time, particularly examining TDP-43 pathology in autopsied cases.
- Findings indicate that medial temporal atrophy is more pronounced in bulbar and upper limb onset subtypes, with a correlation between atrophy progression and TDP-43 pathology severity.