Publications by authors named "Sayuri Guro"
ASP8302 is an orally administered positive allosteric modulator of the muscarinic M receptor. Two Phase 1 studies were conducted, a first-in-human study in Europe and a Japanese phase 1 study. Both were randomized, participant- and investigator-blinded, placebo-controlled, single and multiple ascending oral doses, parallel group, clinical studies in healthy volunteers.
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- The study aimed to identify key factors that affect the effectiveness of exercise training in patients with chronic heart failure by analyzing data from the HF-ACTION study involving 2,130 patients.
- Significant factors influencing exercise effects on mortality and hospitalization included beta-blocker use, pulse pressure, hemoglobin levels, and body mass index, leading to a hypothetical scoring system to identify which patients might benefit most from exercise.
- The research emphasizes the importance of considering individual patient backgrounds when recommending exercise training, while acknowledging that exercise can still benefit many patients with various health issues despite some limitations in the study's findings.
Model-based meta-analysis of changes in circulatory system physiology in patients with chronic heart failure.
CPT Pharmacometrics Syst Pharmacol
September 2021
Article Synopsis
- A model-based meta-analysis (MBMA) was conducted to evaluate how different medications for chronic heart failure (CHF) affect circulatory physiology, focusing on changes in heart rate, blood pressure, and ventricular volumes.
- The study analyzed clinical data from 61 trials primarily involving patients with heart failure with reduced ejection fraction (HFrEF) and investigated medications like carvedilol and enalapril.
- Key findings indicate that estimated myocardial oxygen consumption strongly correlated with mortality rates, supporting the idea that effective CHF treatment reduces cardiac load and enhances patient outcomes.