Publications by authors named "Sayuko Shiraishi"
Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.
Chem Pharm Bull (Tokyo)
March 2017
Article Synopsis
- The study aimed to evaluate how chlorogenic acid (CGA) can suppress the bitterness of the drug diphenhydramine hydrochloride (DPH) using artificial taste sensors and human taste tests.
- The research found that both quinic acid (QNA) and CGA effectively reduced the bitterness of DPH, while caffeic acid (CFA) was less effective.
- H-NMR spectroscopy revealed that the suppression occurs through an electrostatic interaction between the carboxyl group in QNA and CGA with the amine group of DPH, suggesting they could be useful in masking bitterness.
The purpose of this study was to evaluate the taste-masking effects of chlorogenic acid (CGA) on bitter drugs using taste sensor measurements and surface plasmon resonance (SPR) analysis of CGA-drug interactions. Six different bitter drugs were used: amlodipine besylate (AMD), diphenhydramine hydrochloride (DPH), donepezil hydrochloride (DNP), rebamipide (RBM), diclofenac sodium (DCF) and etodolac (ETD). Taste sensor outputs were significantly inhibited by the addition of CGA to all drugs.
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