Publications by authors named "Saygin M"

Article Synopsis
  • The study investigates the neuroprotective effects of Thymoquinone (TQ) and Metformin (MM) on Parkinson's disease by testing their effects separately and in combination on mice.* -
  • Mice treated with TQ, MM, or both showed significant improvements in motor coordination and reduced markers of oxidative stress and neurodegeneration compared to the control group.* -
  • Findings suggest that TQ and MM together may be more effective than either alone, providing evidence for their potential as a therapy for Parkinson's disease.*
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  • The study explored the effects of Vetiveria zizanioides oil (VET) on oxidative stress and cell death in rats that experienced seizures induced by pentylenetetrazol (PTZ).
  • Four groups of rats were observed: a control group, a PTZ only group, and two groups receiving different doses of VET alongside the PTZ treatment.
  • Findings indicated that PTZ increased seizure activity and caused oxidative stress, but treatment with VET significantly reduced these negative effects and improved the overall condition of the rats' brain tissues.
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Although Blastocystis, a protozoan, is commonly found in all species of animals and in humans, there remains a lack of clear information about its epidemiology and routes of transmission. The aim of this meta-analysis study was to determine the changes in Blastocystis prevalence and subtype distribution in humans in Türkiye according to geographical regions. Databases were searched using the Web of Science, PubMed, Scopus, EBSCO, and TRDizin to identify studies on the prevalence of Blastocystis in humans in Türkiye published from 2009 to 2023.

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Background: Although artificial intelligence technologies are still in their infancy, it is seen that they can bring together both hope and anxiety for the future. In the research, it is focused on examining the ChatGPT-4 version, which is one of the most well-known artificial intelligence applications and claimed to have self-learning feature, within the scope of business establishment processes.

Methods: In this direction, the assessment questions in the Entrepreneurship Handbook, published as open access by the Small and Medium Enterprises Development Organization of Turkey, which focuses on guiding the entrepreneurial processes in Turkey and creating the perception of entrepreneurship, were combined with the artificial intelligence model ChatGPT-4 and analysed within three stages.

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Low-loss photonic integrated circuits (PICs) are the key elements in future quantum technologies, nonlinear photonics and neural networks. The low-loss photonic circuits technology targeting C-band application is well established across multi-project wafer (MPW) fabs, whereas near-infrared (NIR) PICs suitable for the state-of-the-art single-photon sources are still underdeveloped. Here, we report the labs-scale process optimization and optical characterization of low-loss tunable photonic integrated circuits for single-photon applications.

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Objectives: We investigated the harmful effects of high fructose corn syrup (HFCS) on learning and memory in the hippocampus and the ameliorative effects of melatonin (Mel).

Materials And Methods: Thirty-six adult male Sprague Dawley rats were divided into three groups: Group I, control; Group II, HFCS; and Group III, HFCS+Mel. HFCS form F55 was prepared as a 20% fructose syrup solution.

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  • This study aimed to determine how moderate-intensity swimming affects learning and memory using the Morris water maze test in aged rats.
  • The experiment involved 32 male rats divided into four groups that either exercised or served as controls over an 8-week period.
  • Results showed that exercise significantly enhanced swim speeds and increased expressions of important proteins (SIRT-1, CREB, BDNF) linked to memory improvement in older rats.
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We consider waveguide lattices as the architecture to implement a wide range of multiport transformations. In this architecture, a particular transfer matrix is obtained by setting step-wise profiles of propagation constants experienced by a field evolving in a lattice. To investigate the capabilities of this architecture, we numerically study the implementation of random transfer matrices as well as several notable cases, such as the discrete Fourier transform, the Hadamard, and permutation matrices.

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Purpose: The purpose of the study was to explore the possible deleterious effects of Methotrexate (MTX) treatment on the urogenital tissues and the potential protective effects of Astaxanthin (AXA).

Methods: Twenty-four female Wistar Albino rats (12 months old) were divided into 3 groups as follows: Group I (Control group): rats received a single dose of 0.1 ml saline by gavage and intraperitoneal injection.

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Photonic information processing demands programmable multiport interferometers capable of implementing arbitrary transfer matrices, for which planar meshes of error-sensitive Mach-Zehnder interferometers are usually exploited. We propose an alternative design that uses a single-static beam splitter (BS) and a variable phase shift as the building blocks. The design possesses superior resilience to manufacturing errors and losses without extra elements added into the scheme.

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The decomposition of large unitary matrices into smaller ones is important because it provides ways to the realization of classical and quantum information processing schemes. Today, most of the methods use planar meshes of tunable two-channel blocks; however, the schemes turn out to be sensitive to fabrication errors. We study a novel decomposition method based on multichannel blocks.

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Purpose: The aim of the study was to investigate the oxidative damage and inflammatory effects of sepsis on the urogenital system in the Lipopolysaccharide (LPS)-induced sepsis model and ameliorating role of Pregabalin (PGB).

Methods: Twenty-four female Wistar Albino rats (12 months old) were divided into 3 groups as follows: Sepsis group (Group S) (5 mg/kg LPS, i.p, single dose); Sepsis+ PGB group (Group SP) (5 mg/kg LPS, i.

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Purpose: The aim of the study was to evaluate the harmful effects of sepsis on the urogynecological tissues and the ability of Lacosamide (LCM) on Lipopolysaccharide (LPS)-induced cytokine production, oxidative stress and apoptotic pathways, in the experimental rat sepsis model.

Methods: Twenty-four female Wistar albino rats (12 months old) were divided into 3 groups as follows: control group (Group I) (0.1 ml/oral and i.

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We investigated the effects of alpha lipoic acid (ALA) on blood and lung tissue exposed chronically to cigarette smoke (CS). Female Sprague-Dawley rats were divided into three groups. Group 1 was the control group (CON): fresh air was supplied twice daily and 0.

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  • * Rats were divided into three groups: a control group, an EMR-only group, and an EMR + vitamin C group, with findings showing significant increases in oxidative stress markers in the EMR-only group.
  • * Results indicated that vitamin C treatment significantly reduced oxidative stress and the expression of harmful proteins (Caspase-3 and Caspase-8) in the ovaries and uterus, suggesting it may offer protective benefits against EMR-induced damage.
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This study investigated the long-term effects of electric fields (EF) which might cause physiopathological or morphological changes in the testis tissues of rats. We assumed that using resveratrol (RES) might reduce harmful effects of the EF. Thirty-two male Wistar Albino rats were randomly divided into four groups with eight animals in each; control, EF, EF + RES and RES.

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Objectives: Effects of air pollution parameters of sulfur dioxide (SO2) and particulate matter (PM10) values on the respiratory system were investigated.

Material And Methods: Data of SO and PM10 were obtained daily for air pollution and classified into two groups: Group I (2006-2007), coal burning years and Group II (2008-2009), natural gas+ coal burning. Groups I and II were divided into two subgroups according to the months of combustion as combustible (November-April) and noncombustible (May-October).

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Objectives: Obstructive sleep apnea (OSA) and enhanced vascular inflammation coexist in patients with coronary artery disease (CAD). Continuous positive airway pressure (CPAP) is first-line treatment for OSA with daytime sleepiness. This analysis of data from the RICCADSA (Randomized Intervention with CPAP in Coronary Artery Disease and Sleep Apnea) trial investigated the effects of CPAP on inflammatory markers in patients with CAD and nonsleepy OSA.

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Integrated optical waveguides, manufactured with femtosecond laser writing (FSLW) technology, enable precise control and manipulation of light in complicated photonic chips. However, due to the intrinsically low anisotropy of FSLW waveguides, polarizing integrated devices have had a relatively large footprint. In this Letter, we demonstrate an approach based on stress-induced anisotropy, allowing us to decrease the size of polarizing directional couplers down to 3.

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Background: To examine the impact of different types of sleep deprivation on hippocampal-mediated learning and memory in rats.

Methods: Forty-eight Sprague-Dawley male rats were randomly assigned to 1 of 4 equal-size groups: (1) 12 hours of sleep per day (control). (2) total sleep deprivation (TSD), (3) rapid eye movement (REM) deprivation (RD), and (4) sleep restricted to 4 hours per day (SR).

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Background: Obstructive sleep apnea (OSA) has been associated with worse diastolic function in patients with coronary artery disease (CAD). This analysis determined whether continuous positive airway pressure (CPAP) treatment would improve diastolic function in CAD patients with nonsleepy OSA.

Methods: Between December 2005 and November 2010, 244 revascularized CAD patients with nonsleepy OSA (apnea-hypopnea index (AHI) ≥15/h, Epworth Sleepiness Scale [ESS] score<10) were randomly assigned to CPAP or no-CPAP.

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Objective: This study was designed to investigate the effects of 2450 MHz EMR on the heart and blood in rat and possible ameliorating effects of melatonin.

Material And Method: Thirty-two female Wistar Albino rats were randomly grouped (by eight in each group) as follows:  Group I: cage-control group (dimethysulfoxide (DMSO), 10mg/kg/day i.p.

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Article Synopsis
  • - The study aimed to assess how methotrexate (MTX) impacts the lungs through markers of inflammation and cell death, and to explore if gallic acid (GA) can offer protective effects.
  • - Twenty-four male rats were divided into three groups: one receiving saline (control), one given MTX, and one treated with both MTX and GA. Various analyses assessed DNA damage, oxidative stress, and inflammation.
  • - Results indicated that MTX significantly increased DNA damage and inflammatory markers in the lungs, while GA treatment reduced these harmful effects, suggesting that GA may have a protective role against MTX-induced lung damage.
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Objectives: This study was performed on Suleyman Demirel University medical students to determine the quality of sleep and to investigate factors that affect of sleep quality.

Material And Methods: Suleyman Demirel University Medical students at 1, 2, 3, 4, 5 and 6 classes included to this cross-sectional analytical study (n= 720). Refused to fill to the survey (188), and students were not come to faculty (195), applied survey to 337 students (46.

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