Publications by authors named "Sayeh Heidari-Nejad"
Article Synopsis
- * The aim is to determine whether SGLT2i can reduce SNS activity independently from its renal benefits, as previous studies primarily concentrated on its renal effects.
- * The study will involve 20 adult participants receiving empagliflozin for 6 weeks, measuring changes in SNS activity, heart rate variability, and overall endothelial function to explore its mechanisms and efficacy further.
Article Synopsis
- Resistant hypertension is when standard treatment doesn't effectively lower blood pressure, leading to increased health risks.
- The endothelin pathway is critical in this condition, but past attempts to use endothelin antagonists were limited.
- A recent study on aprocitentan, a new dual endothelin-receptor antagonist, showed significant BP reduction and safety, leading to its FDA approval, especially benefiting older patients and those with kidney issues.
Article Synopsis
- Resistant hypertension poses a high cardiovascular risk and needs better treatment options, as current therapies often miss key underlying causes.
- Spironolactone is typically the go-to fourth-line treatment, but its use is limited due to side effects like hyperkalemia in certain individuals.
- New studies highlight promising alternatives, such as aprocitentan, baxdrostat, and finerenone, alongside support for catheter-based renal denervation as an effective treatment for resistant hypertension.
Article Synopsis
- Resistant hypertension (RH) is a condition where blood pressure remains high despite using multiple medications, significantly increasing the risk of cardiovascular and kidney issues.
- Many patients, particularly the elderly and those with chronic kidney disease, struggle to manage RH due to the adverse effects of standard fourth-line treatments.
- Recent research from the PRECISION study suggests that the dual endothelin antagonist Aprocitentan is both safe and effective for reducing blood pressure in patients with RH, potentially paving the way for its use as a standard therapy.
Epidemiological studies indicate that exposure to diesel exhaust (DE) is associated with vascular-based disorders. To investigate the effect of DE on blood-brain barrier (BBB) function and integrity, 8-week-old BALB/c mice were randomized to DE in a cyclical treatment regimen over a 2-week period. Functional integrity of BBB was determined by considering brain parenchymal abundance of IgG within the hippocampal formation and cortex at 6 h and 24 h intervals following final exposure treatment.
View Article and Find Full Text PDFBackground: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion of albumin. However, an association of plasma albumin with cognitive performance has not been reported in otherwise healthy participants with clinically acceptable plasma albumin concentrations.
View Article and Find Full Text PDFObjective: We evaluated the effect of terazosin in the improvement of lower urinary tract symptoms and flank pain in patients with internal ureteral stents.
Methods: In this double-blind randomized clinical trial, 73 patients with unilateral ureteral stone and hydroureteronephrosis who underwent insertion of an internal ureteral stent after transureteral lithotripsy (TUL) were randomized into two groups. 37 patients received terazosin 2 mg (once nightly) for 4 weeks and 36 patients received placebo for the same time duration.