Publications by authors named "Sayegh S"

Background: Obesity is a chronic disease associated with other associated medical problems, including atherogenic dyslipidemia. Metabolic bariatric surgery (MBS) has been shown to reduce long-term cardiovascular risk (CVR). Anti-ApoA-1 antibodies (AAA1) are independently associated with cardiovascular disease, which remains a major cause of death in individuals with obesity.

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Vitamin B12 deficiency is a significant concern among patients with end-stage renal disease undergoing dialysis. However, there hasn't been extensive research conducted on this particular patient group. The reported incidence rates vary widely, ranging from 20% to 90%, reflecting the complexity of its diagnosis.

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  • Opioid use in hospitalized patients with chronic kidney disease (CKD) poses safety concerns, especially as the literature on the topic is limited, making it crucial to understand associated complications for patients with impaired kidney function.
  • A study analyzed data from the National Inpatient Database from 2016 to 2020, focusing on CKD patients and their experiences with opioid prescriptions, finding that as CKD progressed, the likelihood of uncomplicated opioid use decreased, while complicated use increased in patients with milder CKD stages.
  • The results indicate that healthcare providers are more careful when prescribing opioids to those with advanced CKD, leading to fewer prescriptions in this group, while complicated opioid use remains a significant predictor of poisoning, regardless of CKD
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  • Patients with autoimmune diseases, particularly those with inflammatory bowel disease (IBD), face a higher risk of metabolic syndrome (MetS) and cardiovascular disease (CVD), yet research on this is limited.
  • A retrospective study examining data from the National Inpatient Sample over five years found that while IBD patients had lower overall prevalence of MetS components compared to non-IBD patients, ulcerative colitis (UC) patients had a higher prevalence than those with Crohn's disease (CD).
  • The study demonstrated that higher metabolic scores associated with MetS components were linked to increased risks of acute coronary syndrome and arrhythmias, with significant odds ratios indicating a strong correlation between MetS and heart failure in both IBD types.
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Background: Acute heart failure in patients with prosthetic heart valves is a complex problem with clinical and therapeutic challenges. Systemic sclerosis is a chronic autoimmune disease frequently associated with valvular abnormalities. The association between systemic sclerosis and acute heart failure in patients with prosthetic heart valves remains understudied.

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Nivolumab is an immune checkpoint inhibitor (ICI) that treats various malignancies. Although ICIs have proven efficacious, they can also have detrimental side effects. We present a case of nivolumab-induced quadriparesis mimicking Guillain-Barré syndrome in a patient with stage III squamous cell carcinoma (SCC) of the pharynx with a chronic tracheostomy, who presented after being found unconscious at home.

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  • The study investigates how different types of senescent cells in the skin contribute to the development of cancer in patients with Familial Melanoma Syndrome (FMS), who have defects in the CDKN2A gene.
  • Melanocytes from FMS patients show lower p16 levels and higher DNA damage markers compared to fibroblasts, while patient fibroblasts also exhibit unusual behaviors, such as increased replicative capacity and defective senescence.
  • The findings suggest that the combination of DNA damage in melanocytes and impaired senescence in fibroblasts may weaken the immune response and enhance the risk of melanoma in these patients.
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The development of poly(lactic acid) (PLA) nanocomposites incorporating urchin-like WO particles through a cost-effective solution-casting method has led to significant enhancements in structural, thermal, optical, and rheological properties. The incorporation of these WO particles up to 7 wt% resulted in the formation of an irregular honeycomb-like morphology with broad pore sizes ranging from 14.1 to 24.

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  • Understanding the performance of internal combustion engines is essential for improving emissions and fuel efficiency, particularly in urban settings like Shiraz city, where factors like working days versus holidays play a significant role.
  • * The research involved collecting data on vehicle speed and analyzing driving patterns during peak traffic times, utilizing methods like K-means clustering and principal component analysis to create representative driving cycles for testing.
  • * Findings revealed that fuel consumption was about 8% higher on holidays due to increased driving times and speeds, which also led to a notable rise in CO and NOx emissions, while HC emissions were higher on working days, underscoring the need for optimizing driving behavior to promote sustainable transport.
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This study aims to investigate the safety and efficacy of guideline-directed fluid resuscitation (GDFR) compared with conservative fluid management in end-stage renal disease (ESRD) patients with sepsis by evaluating 90-day mortality and intubation rate. Following PRISMA guidelines, a systematic review was conducted across multiple databases using specific keywords and controlled vocabulary. The search strategy, implemented until October 1, 2023, aimed to identify studies examining fluid resuscitation in ESRD patients with sepsis.

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The advancement of renal replacement therapy has significantly enhanced the survival rates of patients with end-stage renal disease (ESRD) over time. However, this prolonged survival has also been associated with a higher likelihood of cancer diagnoses among these patients including breast cancer. Breast cancer treatment typically involves surgery, radiation, and systemic therapies, with approaches tailored to cancer type, stage, and patient preferences.

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  • Disseminated intravascular coagulation (DIC) is a frequent but serious complication in Acute Myeloid Leukemia (AML), linked to increased cardiovascular issues not previously reported.* -
  • In a study analyzing 37,344 AML patients, those with DIC were younger, predominantly male, and showed significantly higher rates of mortality and acute cardiovascular events like myocardial infarction and pulmonary edema.* -
  • The research stresses the need for vigilant cardiovascular monitoring in AML patients with DIC, pointing to complex biological factors that contribute to these complications and suggesting further research for better management strategies.*
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Background: Cardiovascular disease (CVD) is the leading cause of mortality in kidney transplant (KT) patients. The perceived risk of contrast-induced nephropathy (CIN) may create a reluctance to perform coronary angiography in patients presenting with non-ST segment elevation myocardial infarction (NSTEMI).

Methods: National Inpatient Sample (NIS) Database was used to sample individuals presenting with NSTEMI.

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Introduction: The COVID-19 pandemic led to restrictions that prevented physical activity in public places. This study sought to conduct a comprehensive longitudinal analysis of how lockdown policies in an Arabian Gulf country influenced the patterns of physical activity during first wave.

Methods: In a longitudinal study design, members of the ongoing "Step into health" community-based health promotion program who provided valid pedometer data from January to August 2020, covering pre, during and post-covid first wave period met the inclusion criteria.

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The evolving field of photocatalysis requires the development of new functional materials, particularly those suitable for large-scale commercial systems. One particularly promising approach is the creation of hybrid organic/inorganic materials. Despite being extensively studied, materials such as polydopamine (PDA) and titanium oxide continue to show significant promise for use in such applications.

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Vitamin D replacement in older insufficient adults significantly improves their antigen-specific varicella zoster virus (VZV) cutaneous immunity. However, the mechanisms involved in this enhancement of cutaneous immunity are not known. Here, we show for the first time that vitamin D blocks the senescence-associated secretory phenotype (SASP) production by senescent fibroblasts by partially inhibiting the p38 MAPK pathway.

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Primary hyperthyroidism (PHPT) is a relatively uncommon disease and leads to increased calcium levels. Ionized calcium, known as clotting Factor IV, may lead to overt coagulation cascade activation, increasing the risk of venous thromboembolism (VTE). National Inpatient Sample Database was used to sample individuals with primary hyperparathyroidism, and baseline demographics and comorbidities were collected using ICD-10 codes.

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  • Inflammatory bowel disease (IBD) is a chronic condition affecting the gastrointestinal tract, and biologic drugs are commonly used to manage inflammation by targeting the immune system.
  • Recent research indicates a possible connection between these biologic drugs and a higher risk of kidney stones (nephrolithiasis), prompting further investigation into this link.
  • The study analyzed data from 22,895 patients, revealing that those treated with Vedolizumab had a 31% higher likelihood of developing nephrolithiasis, especially when using multiple biologic medications.
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Background: Atrial fibrillation (Afib) is one of the most common and significant risk factors for stroke, with the CHADsVAsc score used as the tool for stroke risk assessment. Pulmonary hypertension (PH) has not been studied as an independent risk factor for stroke in individuals with Afib.

Methods: In this retrospective case-control study, National Inpatient Sample Database was used to sample individuals with atrial fibrillation, and baseline demographics and comorbidities were collected using ICD-10 codes.

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Introduction: Inconvenient administration and side effects of some disease-modifying therapies (DMTs) for relapsing multiple sclerosis (RMS) can deter adherence. We evaluated treatment satisfaction with cladribine tablets (CladT) for RMS in the Arabian Gulf.

Methods: This was a non-interventional, multicentre, prospective observational study in non-pregnant/lactating adults (aged ≥ 18 years) with RMS eligible for 1st treatment with CladT (EU labelling).

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Background: Transgender people experience extreme rates of violence and the electronic medical record (EMR) remains a mostly untapped resource to study the medical sequelae of such experiences.

Objectives: To develop and test a method for identifying experiences of violence using EMR data.

Research Design: Cross-sectional study utilizing EMR data.

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Aim: This study evaluated the color aging of two computer aided design/computer aided manufacturing (CAD/CAM) provisional materials of different compositions (polymethyl methacrylate and composite resin) after exposure to thermal aging and immersion in coffee for 3, 6, and 12 intraoral months.

Setting And Design: The current in vitro study was conducted from September to December 2021 at the Craniofacial laboratory at the Saint Joseph University in Beirut, Lebanon.

Materials And Methods: The shades of 2.

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Objective: The Lebanese Active Healthy Kids Work Group (LAHKWG) synthesized literature published on physical activity (PA) indicators among ages 5- to 17- year-olds, using a recommended harmonized process by the Active Healthy Kids Global Alliance (AHKGA), to explore Lebanon's performance since its previous report card publication.

Methods: Peer reviewed literature, national surveys, and gray literature published since 2017, on 10 common AHKGA and two LAHKWG recommended indicators were examined. Common indicators included overall PA, organized sport and PA, active play, active transportation, community and environment, sedentary behaviors, physical fitness, family and peers, school, and government.

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