Publications by authors named "Sayegh H"

Introduction: Calcified bladder foreign bodies are a rare yet clinically significant entity, often introduced voluntarily or in psychiatric contexts. Their diagnosis is frequently delayed due to nonspecific symptoms and the concealed circumstances of their introduction.

Case Presentation: We report the case of a 37-year-old man, treated for schizophrenia, presenting with chronic urinary symptoms.

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Introduction And Importance: Tuberculosis (TB) remains a significant public health issue, especially in developing countries where its incidence is rising due to factors like overcrowding and immunosuppression. Among extrapulmonary TB forms, abdominal TB is common, while retroperitoneal TB is rare and often challenging to diagnose due to its similarity to other retroperitoneal tumors. Diagnosis typically requires invasive procedures such as laparoscopy or laparotomy.

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Introduction: Multilocular cystic nephroma is an uncommon condition with only few cases described in the literature, although its benign nature is well-recognized.

Case Presentation: We present a case of a 28-year-old male patient who presented with a right flank pain, imaging suspected a multicystic renal cell carcinoma. A radical nephrectomy was performed view the size of the cyst and the high tumor complexity, which histology confirmed the diagnosis of multilocular cystic nephroma.

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Purpose: Novel therapies targeting specific genomic alterations are a promising treatment approach for relapsed/refractory cancer. Patients with specific alterations may be more likely to respond. Trial designs should maximize opportunities for such patients to enroll on these trials.

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Introduction: Urethral caruncle is a benign lesion located at the urethral meatus, predominantly affecting postmenopausal women. Though often asymptomatic, it can sometimes present with symptoms that significantly impact the patient's quality of life. Diagnosis is usually straightforward based on physical examination.

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Article Synopsis
  • - Hypertension (HTN) is the most common additional health issue found in cancer patients, affecting both those with pre-existing conditions and those who develop it due to cancer treatments.
  • - Various cancer therapies, such as VEGF inhibitors, Bruton tyrosine kinase inhibitors, and proteasome inhibitors, have been linked to the onset of HTN in patients.
  • - The causes of hypertension from these therapies can be due to direct effects on blood vessels (like with VEGF inhibition) or other unclear mechanisms not fully understood yet.
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In recent years, the utilization of enterocystoplasty for bladder function enhancement has increased, albeit accompanied by risks such as stone formation, necessitating vigilant follow-up. We report a case of a 60-year-old female with a neobladder who presented with back pain, constipation, and pelvic heaviness, revealing multiple large stones in imaging. Stone analysis showed calcium oxalate and magnesium.

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Introduction: Pheochromocytoma is a rare neuroendocrine tumor that arises from chromaffin cells in the adrenal medulla, with an incidence of 2-8 cases per million adults.

Case Presentation: This case study presents the case of a 39-year-old male patient who experienced recurrent headaches, palpitations, and hypertension, ultimately diagnosed with malignant pheochromocytoma after imaging revealed a large adrenal mass with vascular invasion and metastasis.

Discussion: Despite the rarity of malignant pheochromocytomas, they present significant clinical challenges.

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Article Synopsis
  • * A 41-year-old male with chronic left scrotal swelling was diagnosed with testicular tuberculosis after imaging and histopathology revealed caseating granulomas and acid-fast bacilli.
  • * The patient had surgery to remove the affected testicle and received a standard four-drug TB treatment, but follow-up showed he had permanent fertility impairment due to azoospermia.
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Introduction: This case highlights a rare occurrence of combined penile fracture and urethral injury in a 35-year-old male, emphasizing the critical need for accurate diagnosis and precise surgical intervention in such cases.

Case Presentation: After a mishap during sexual intercourse, the patient faced intense penile pain, swelling, and urethrorrhagia. Advanced diagnostic methods, particularly MRI, confirmed a disruption in the tunica albuginea within the left corpora cavernosa.

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Introduction Laparoscopic nephrectomy is the gold standard for kidney removal in living donors, offering advantages such as reduced pain and quicker recovery. In Morocco, where end-stage renal disease (ESRD) is a growing concern, this approach could significantly impact the demand for kidney transplants. This study evaluates the safety and efficacy of laparoscopic live donor nephrectomy in the Moroccan healthcare system.

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Introduction And Importance: Emphysematous cystitis is a rare and serious urinary tract infection with gas in the bladder, commonly affecting elderly diabetic women. Prompt evaluation and management are vital due to its potential life-threatening nature, associated with risk factors like diabetes, neurogenic bladders, and urinary stasis.

Case Presentation: A 55-year-old woman with type 1 diabetes presented confusion, lumbar pain, and urinary symptoms.

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Wilms' tumor (nephroblastoma) is rare in adults, comprising less than 5 % of renal cancers. This report details a 48-year-old male with persistent abdominal pain, weight loss, and fatigue, whose imaging showed a large, heterogeneous left renal mass with regional lymph node involvement. Post-nephrectomy histology confirmed nephroblastoma with a triphasic pattern.

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Article Synopsis
  • Textilomas, or gossypibomas, are rare but serious complications from forgotten surgical sponges that can cause inflammatory reactions, abscesses, and are often mistaken for tumors like sarcomatoid carcinoma.
  • In a case study involving a 58-year-old woman with back pain and a retroperitoneal mass, imaging misidentified the mass as a tumor, but surgery revealed it was actually a textiloma.
  • Accurate diagnosis relies on medical history and imaging techniques, such as CT and MRI, and despite the reduced incidence due to radio-opaque sponges, careful counting remains necessary to prevent these complications.
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Nile tilapia fish skin () has been increasingly used in human and veterinary medicine in xenografts for treatment of burn wounds. The objective of this study was to self-prepare the graft using a Brazilian patent (WO2017/035615 A1) as a guide and apply it to full-thickness wounds in zoological species ( = 4). The wounds, which were all characterized as contaminated wounds in which the entire dermal layer was missing, had all previously been surgically debrided and treated with traditional wound-healing techniques without success.

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  • The study focused on gram-negative bacteremia (GNB) in cancer patients, looking at characteristics, outcomes, and risk factors for multi-drug-resistant (MDR) GNB.
  • Researchers analyzed data from 1,074 patients admitted in 2022, finding that almost half of GNB cases were MDR and linked previous antibiotic use to higher MDR risk.
  • The results showed that MDR-GNB led to longer hospital stays and greater recurrence of infections but did not significantly increase 30-day mortality compared to non-MDR cases.
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Embryonal rhabdomyosarcoma of the prostate in adults is rare and often diagnosed at an advanced stage, with metastases. We report the case of a 23-year-old young adult presenting with low back pain and dysuria, whose imaging revealed a voluminous metastatic prostate mass. Biopsy confirmed embryonal rhabdomyosarcoma.

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Introduction: Renal cell carcinoma is one of the 10 most common malignancies. Partial nephrectomy (PN) is the preferred treatment for localized ones. The incidence of local recurrence (LR) after a PN varies between zero and 17% in the literature.

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Objectives: species frequently cause bloodstream infections; however, there is a lack of epidemiological studies on candidemia in Oman.

Methods: To address this, we conducted a retrospective study at Sultan Qaboos Comprehensive Cancer and Research Center from October 2021 to October 2023.

Results: Our study identified 27 episodes of candidemia among 26 patients with cancer, with an incidence of 4.

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  • The study aimed to investigate the occurrence and management of endocrine disorders resulting from immune checkpoint inhibitors (ICIs) in cancer patients, specifically focusing on PD-1/PD-L1 inhibitors at a cancer center in Oman.
  • Out of 139 patients analyzed, 28% experienced thyroid-related issues, with hypothyroidism being the most common, followed by a few cases of hyperthyroidism and other rarer endocrine complications.
  • The findings highlight that factors like weight and body mass index (BMI) play a significant role in the likelihood of developing these endocrine immune-related adverse events, emphasizing the need for healthcare providers to monitor patients closely for potential endocrine dysfunctions post-treatment.
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Introduction And Importance: This case report describes the successful use of a latissimus dorsi muscle flap attached to the femoral vessels to cover a large mass loss in a 27-year-old woman with bladder exstrophy. The two-stage reconstruction showed excellent results six months after surgery.

Case Presentation: A 27-year-old woman with bladder exstrophy and previous enterocystoplasty with Mitrofanoff-type urinary diversion combined with a late fascial flap presented 10 years later with disembowelment near the pubic symphysis.

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Risk assessment models that are applied to assess the lifetime risk of cancer and pathogenic variant risk are more commonly used in Western populations. Using these models, without validation, for non-Western populations has been questioned. This study aimed to evaluate the use and consistency of the Manchester Scoring System as a risk assessment model for the Omani population.

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Although germ cell tumours can appear in childhood, they are most common around the age of 30. These tumours are highly responsive to chemotherapy, and even cases of relapse have relatively high cure rates. There is limited literature on patients diagnosed after the age of 50, and no specific trials have been carried out in this context.

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Objectives: This study aimed to report the demographic features, clinical presentation, pathological types and long-term outcomes of patients diagnosed with endometrial cancer (EC) in Oman. EC is the sixth most common cancer in women worldwide and the fifth most common cancer in women in Oman. Survival outcomes of EC have not been reported previously from Oman.

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Introduction: Ligation of the renal pedicle is a crucial step in laparoscopic renal harvesting. Currently, two devices are widely used: Hem-o-Lok® clips and staplers. Each has its advantages and disadvantages.

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