Association of Free-to-Total PSA Ratio and F-DCFPyL Prostate-Specific Membrane Antigen PET/CT Findings in Patients with Biochemical Recurrence After Radical Prostatectomy: A Prospective Single-Center Study.

In Canada and across the globe, access to PSMA PET/CT is limited and expensive. For patients with biochemical recurrence (BCR) after treatment for prostate cancer, novel strategies are needed to better stratify patients who may or may not benefit from a PSMA PET scan. The role of the free-to-total prostate-specific antigen (PSA) ratio (FPSAR) in posttreatment prostate cancer, specifically in the PSMA PET/CT era, remains unknown.

Assessing the therapeutic and toxicological profile of novel GLP-1 receptor agonists for type 2 diabetes.

Introduction: GLP-1 receptor agonists provide multiple benefits for patients with type 2 diabetes. Nonetheless, there are also several significant adverse effects associated with these agents. A thorough understanding of both therapeutic and toxicological profiles of GLP-1 receptor agonists is crucial for appropriate utilization of this medication class.

Reentrant melting of lanes of rough circular disks.

We consider binary suspension of rough, circular particles in two dimensions under athermal conditions. The suspension is subject to a time-independent external drive in response to which half of the particles are pulled along the field direction, whereas the other half is pushed in the opposite direction. Simulating the system with different magnitude of external drive in steady state, we obtain oppositely moving macroscopic lanes only for a moderate range of external drive.

Parametric Analysis of Epoxy/Crumb Rubber Composite by Using Taguchi-GRA Hybrid Technique.

Effect of parameters affecting solid particle erosion of crumb rubber epoxy composite is investigated. Five important process parameters-impact velocity, impingement angle, standoff distance, erodent size, and crumb rubber content-are taken into consideration. Erosion rate and erosion efficiency are included as the chief objectives.

Perplexing case of lung mass perfectly mimicking a malignancy.

A 35-year-old man, a known asthmatic and with a history of smoking presented with a history of recurrent episodes of mild haemoptysis. On examination, there was decreased intensity of breath sounds on the right infraclavicular area. The chest X-ray and CT chest showed a mass in right upper lobe with nodules in the other lobe.

Experimental Evaluation of Interfacial Surface Cracks in Friction Welded Dissimilar Metals through Image Segmentation Technique (IST).

Surface cracks on the friction welded interface of dissimilar metals are one of the earliest indications of degradation of the joint, which is a critical aspect for the welding strength. By manual inspection of the friction welded joint, observations of irregularities, porosity voids, crack lengths, cracked surfaces, and depth penetrations of two dissimilar metals can be made. Manual inspection purely depends on a quality expert's experience of quantitative analysis and knowledge.

Design, Development and FE Thermal Analysis of a Radially Grooved Brake Disc Developed through Direct Metal Laser Sintering.

The present research work analyzed the effect of design modification with radial grooves on disc brake performance and its thermal behavior by using additive manufacturing based 3D printed material maraging steel. Temperature distribution across the disc surface was estimated with different boundary conditions such as rotor speed, braking pressure, and braking time. Design modification and number of radial grooves were decided based on existing dimensions.

Active particle condensation by non-reciprocal and time-delayed interactions.

We consider the flocking of self-propelling agents in two dimensions, each of which communicates with its neighbors within a limited vision-cone. Also, the communication occurs with some time-delay. The communication among the agents are modeled by Vicsek rules.

Tuberculosis presenting as broncho-oesophageal fistula in a young healthy man.

A 21-year-old Saudi man presented with a history of dysphagia and choking. CT scan of the chest showed clear evidence of chronic recurrent aspiration pneumonia in the left lung. It also showed a fistula connecting the left main bronchus to the oesophagus.

Host-guest interaction of 3-hydroxyflavone and 7-hydroxyflavone with cucurbit [7]uril: A spectroscopic and calorimetric approach.

The modulation of photophysical behaviour of small organic molecules in the presence of macrocycles is one of the most interesting areas of research. In this work we reported the interaction of two biologically active molecules 3-hydroxyflavone and 7-hydroxyflavone with macrocyclic host cucurbit [7]uril in aqueous medium. To investigate the change of photophysical properties of these two flavones, we have used steady state absorption, fluorescence, time resolved fluorescence emission spectroscopy and isothermal titration calorimetric technique.

Study on risk factors (predisposing factors) for poor diabetes control during Hajj (1436/2015) in people with diabetes.

Background And Objective: Each year millions of Muslims perform pilgrimage to Makkah, Saudi Arabia. It is particularly stressful during the peak five days, when all rituals have to be performed at specific periods of time at different sites. Poor diabetes control in people with diabetes predisposes to morbidity and increases risk of acute complications.

Salvage myocardial revascularisation in spontaneous left main coronary artery dissection with cardiogenic shock - the role of mechanical circulatory support.

Spontaneous left main coronary artery dissection is a rare cause of acute coronary events or sudden cardiac death, constituting less than 1% of all epicardial coronary artery dissections. It is often fatal and is mostly recognized at post-mortem examination in young victims of sudden death. More than 70% of the reported cases occurred in women, particularly during pregnancy and the peripartum period and those on oral contraceptives.

Interaction of Biologically Active Flavins inside Bile Salt Aggregates: Molecular Level Investigation.

In this work we have studied the photophysics of biologically active flavin molecule lumichrome (LCM) in different bile-salt aggregates. With alteration of the functional groups of the bile salts, the photophysics of confined fluorophore is largely affected and shows difference in their spectral behavior. This study also reveals the selective prototropic species of LCM present in bile salt aggregates.

First-order phase transition in a model of self-propelled particles with variable angular range of interaction.

We have carried out a Monte Carlo simulation of a modified version of Vicsek model for the motion of self-propelled particles in two dimensions. In this model the neighborhood of interaction of a particle is a sector of the circle with the particle at the center (rather than the whole circle as in the original Vicsek model). The sector is centered along the direction of the velocity of the particle, and the half-opening angle of this sector is called the "view angle.

Surfactants induced release of a red emitting dye from the nanocavity of a molecular container: A spectroscopic and calorimetric study.

Supramolecular interaction of a red emitting dye Nile blue A (NBA) with Cucurbit[7]uril (CB7) in aqueous solution was studied and the release of the dye from the hydrophobic cavity of CB7 was reported. To investigate the supramolecular host-guest complex formation and release of dye, we have used the steady state absorption, fluorescence and time resolved fluorescence emission spectroscopy, (1)H NMR spectroscopy and isothermal titration calorimetry (ITC). The spectral properties of NBA were changed in the presence of CB7.

Safety Analysis of Adjuvant Chemotherapy with Docetaxel Administered with or without Anthracyclines to Early Stage Breast Cancer Patients: Combined Results from the Asia- Pacific Breast Initiatives I and II.

Background: The Asia-Pacific Breast Initiatives (APBI) I and II registries were established to collect safety data for patients with early stage breast cancer receiving adjuvant docetaxel-based regimens in the Asia-Pacific region.

Materials And Methods: Data from the two registries were combined to perform a safety analysis. Participants in the registry were women with early stage operable breast cancer with an intermediate or high risk of recurrence.

Docetaxel-based adjuvant therapy for breast cancer patients in Asia-Pacific region: Results from 5 years follow-up on Asia-Pacific Breast Initiative-I.

Aim: To acquire patient characteristics, safety, relapse and survival outcomes of early-stage breast cancer patients receiving docetaxel (Taxotere(R))-based regimen in adjuvant setting from the Asia-Pacific region.

Methods: This was an open-label, international, longitudinal, multicenter, observational, prospective cohort of consecutive early breast cancer (EBC) patients with a high risk of recurrence being treated with various docetaxel-containing anthracycline and non-anthracycline adjuvant regimens during 2006-2013.

Results: In this study, 1542 patients were enrolled.

Supramolecular interaction of a cancer cell photosensitizer in the nanocavity of cucurbit[7]uril: A spectroscopic and calorimetric study.

The interaction of small biologically active molecules in the nanocavity of supramolecular host is very interesting and thriving research area. In the presence of supramolecular host the absorption and emission properties of small biologically active molecules were modulated several folds compared to bulk solution. In this study we have investigated the supramolecular interaction of a cancer cell photosensitizer molecule harmane in the presence of cucurbit[7]uril (CB7) as host in aqueous buffer solution (pH∼7.

Photophysics and Rotational Dynamics of a Hydrophilic Molecule in a Room Temperature Ionic Liquid.

We have studied the photophysics and rotational diffusion of hydrophilic solute 7-(N, N'-diethylamino)coumarin-3-carboxylic acid (7-DCCA) in a room temperature ionic liquid methyltrioctylammonium bis(trifluoromethylsulfonyl) imide ([N1888 ][NTf2 ]). Comparison of activation energies of viscous flow and nonradiative decay shows that the photophysical properties of 7-DCCA are not guided by the bulk viscosity of the medium but are dependent on the specific solute solvent interaction and structural heterogeneity of the medium. The rotational relaxation behaviour of 7-DCCA in [N1888 ][NTf2] shows significant deviation from the Stokes Einstein Debye hydrodynamic model of rotational diffusion.

Interaction of the nonsteroidal anti-inflammatory drug indomethacin with micelles and its release.

In this study, we have reported the binding interaction and photophysics of a nonsteroidal anti-inflammatory drug (NSAID) indomethacin (IMC) in the presence of different micelles. We have used several spectroscopic techniques such as UV-vis absorption, steady state fluorescence and time-resolved fluorescence emission spectroscopy. The spectral properties of IMC were modulated in the presence of micelles compared to that in neat water.

Photophysics and rotational diffusion of hydrophilic molecule in polymer and polyols.

In this work we report the photophysics and rotational diffusion of a hydrophilic solute 7-(N,N'-diethylamino)coumarin-3-carboxylic acid (7-DCCA) in four protic solvents: poly(ethylene glycol), ethylene glycol, tetraethylene glycol, and glycerol, with variation of temperature. The cumulative effect of polarity, viscosity, and structural features of these solvents, as well as specific solute-solvent interaction on the photophysical properties of 7-DCCA was discussed. We observed significant differences in both steady-state and time-resolved emission properties.