Microfluidic system for synthesis of nanofibrous conductive hydrogel and muscle differentiation.

Microscale hydrogels can be synthesized within microfluidic systems and subsequently assembled to make tissues composed of units such as myofibers in muscle tissue. Importantly, the nanofibrous surface of hydrogels is essential for tissue engineering aims due to inducing beneficial cell-surface interactions. In this study, a new microfluidic platform, embedded with a hydrogel, was introduced that allowed for performing multiple non-parallel steps for the synthetic approaches.

The activation of satellite cells by nanofibrous poly ε-caprolacton constructs.

Nanoscale patterning of scaffolds provides broad surface for adhesion and differentiation of stem cells. As we know, the combination of tissue engineering with stem cells technology hold the key for regeneration of damaged tissues for example skeletal muscle tissues. On the other hand, the mechanical assessments of poly ε-caprolacton nanofibers determined the required features of biomedical scaffold for skeletal muscle tissue.