Comprehensive analysis of electrochemical biosensors for early ovarian cancer detection.

Ovarian cancer is one of the leading causes of mortality among women worldwide. However, early detection can significantly reduce mortality rates and mitigate subsequent complications related to both economic burden and mental well-being. Despite the development in the field of medical diagnosis, the death rates due to ovarian cancer have sharply increased.

Doxorubicin-loaded methoxy-intercalated kaolinite as a repackaging of doxorubicin for an enhanced breast cancer treatment: in vitro and in vivo investigation.

Doxorubicin is one of the most common wide-spectrum chemotherapeutics. However, its efficacy is limited due to off-target accumulation and selectivity issues. In this study, we compared the anti-cancer effect and biocompatibility of KaoliniteMeOH-Dox, a doxorubicin repackaging, to doxorubicin monotherapy.

Radiation sensor based on a 1D-periodic structure infiltrated by (B-co-MP) a conjugated copolymer.

In this study, a novel gamma-ray radiation sensor has been developed depending on a 1D photonic crystal (1D-PhC). Based on porous silicon (PSi) layer that has been penetrated by a conjugated copolymer (B-co-MP) which consists of BEHP-PPV and MEH-PPV, with a fractional ratio of 60:40. The suggested method for the development of the dosimeter is based on the shift of photonic band-gap to shorter wavelengths, where exposure to gamma-ray radiation at doses ranging from 0 to 20 kGy alters the refractive index of the (B-co-MP) copolymer.

Bidentate bromhexine drug coordination modes with various transition metal ions: Synthesis, characterization, and in vitro antibacterial and anti-breast cancer activity tests.

Background: Bromhexine (BHX) is a mucolytic drug used in treatment the respiratory disorders which are associated with excessive or viscid mucus. Transition metal complexes have made tremendous progress in the treatment of a variety of human ailments, according to reported articles. Transition metal complexes are being developed as medications with a lot of effort.

Linear Morphea in the Context of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Unique Dermatological Manifestation.

Morphea, a rare skin disorder characterized by localized areas of thickened and sclerotic skin, typically presents as circumscribed plaques. The linear variant, however, manifests as linear bands of sclerosis affecting the extremities, and its association with coronavirus disease 2019 (COVID-19) has not been documented until now. In this article, we present the case of a 22-year-old previously healthy female patient who contracted COVID-19 complicated by an erythroedema on the back of the right hand, extending notably to the forearm on the 10th day of the infection.

Single-stage revision for total shoulder arthroplasty infection. Results at a minimum 2 years follow-up.

Introduction: Similar to the management of periprosthetic joint infections of the lower limb, one-stage revision in total shoulder arthroplasty (TSA) infections is an option that has been highlighted in scientific publications since the early 2010s. However, there are only a few studies which validate this treatment and determine its scope of application in relation to two-stage treatment.

Hypothesis: Single-stage revision for infected TSA is a reliable treatment allowing good infection control and satisfactory functional results.

A prospective multicentre evaluation of BioFire® Joint Infection Panel for the rapid microbiological documentation of acute arthritis.

Objectives: To assess the performance of the rapid syndromic BioFire® Joint Infection Panel (BF-JIP) to detect bacterial and fungal pathogens, as well as antibiotic resistance genes, directly in synovial fluid specimens collected from patients with acute arthritis.

Methods: The study was conducted in six French bacteriological laboratories. To assess the performances of BF-JIP, results were compared with those of synovial fluid 14-day culture and, in case of discrepancy, with those of complementary molecular methods and intraoperative samples.

Jahn-Teller Distortions and Phase Transitions in LiNiO: Insights from Ab Initio Molecular Dynamics and Variable-Temperature X-ray Diffraction.

The atomistic structure of lithium nickelate (LiNiO), the parent compound of Ni-rich layered oxide cathodes for Li-ion batteries, continues to elude a comprehensive understanding. The common consensus is that the material exhibits local Jahn-Teller distortions that dynamically reorient, resulting in a time-averaged undistorted 3̅ structure. Through a combination of ab initio molecular dynamics (AIMD) simulations and variable-temperature X-ray diffraction (VT-XRD), we explore Jahn-Teller distortions in LiNiO as a function of temperature.

Angular surface plasmon resonance-based sensor with a silver nanocomposite layer for effective water pollution detection.

For sensing various samples of polluted water and various sodium chloride concentrations using an angular surface plasmon resonance (ASPR), we have introduced a conventional structure and a hybrid heterostructure in the current research. The suggested structures are composed of silver metal, dielectric layers, silver nanocomposite, and a sensing medium. The reflectance spectra of all structures in the visible region were obtained through the utilization of the transfer matrix method by using the angular interrogation method depending on the Kretschmann configuration.

Comparative Evaluation of the Relationship Between Airway Inadequacy, Head Posture, and Craniofacial Morphology in Mouth-Breathing and Nasal-Breathing Patients: A Cephalometric Observational Study.

Background: The process of respiration is the primary factor of the posture of the jaws and tongue. Thus, a changed respiratory form like mouth breathing can change the posture of the head, jaw, and tongue. This, in turn, could change the equilibrium of pressure on the jaws and teeth thus affecting jaw growth and teeth positions.

Does Heat Play a Role in the Observed Behavior of Aqueous Photobatteries?

Light-rechargeable photobatteries have emerged as an elegant solution to address the intermittency of solar irradiation by harvesting and storing solar energy directly through a battery electrode. Recently, a number of compact two-electrode photobatteries have been proposed, showing increases in capacity and open-circuit voltage upon illumination. Here, we analyze the thermal contributions to this increase in capacity under galvanostatic and photocharging conditions in two promising photoactive cathode materials, VO and LiMnO.

Sonochemical synthesis of heterostructured ZnO/BiO for photocatalytic desulfurization.

In this study, metal oxides nanoparticles heterogeneous photocatalysts prepared by coprecipitation and ultrasonic techniques were used for diesel desulfurization. They were characterized by scanning electron microscope, powder X-ray diffraction, energy dispersive analysis, diffused reflectance spectra, photoluminescence analysis and BET surface area. The surface area of catalyst B is larger than catalyst A confirming its higher reactivity.

Some novel bioactivities of carotenoids, isolated from Wadi El-Natrun lakes.

Carotenoids come in second among the most frequent natural pigments and are utilized in medications, nutraceuticals, cosmetics, food pigments, and feed supplements. Based on recent complementary work, Virgibacillus was announced for the first time as a member of Wadi El-Natrun salt and soda lakes microbiota, identified as Virgibacillus halodenitrificans, and named V. halodenitrificans DASH; hence, this work aimed to investigate several medicinal bioactivities of V.

A cost analysis of medical students applying to neurological surgery residency: An analysis of the Texas STAR database.

Introduction: Medical Students applying to neurosurgery residency programs incur substantial costs associated with interviews, away rotations, and application fees. However, few studies have compared expenses prior to and during the COVID-19 pandemic. This study evaluates the financial impact of COVID-19 on the neurosurgery residency application and identifies strategies that may alleviate the financial burden of prospective neurosurgery residents.

Sleep Quality and Its Affecting Factors among Hemodialysis Patients: A Multicenter Cross-Sectional Study.

(1) Background: Sleep quality is one of the most important clinical outcomes of hemodialysis (HD) patients, as it can affect their physical and mental health. This study aimed to investigate sleep quality and its affecting factors among patients with HD. (2) Methods: A cross-sectional design was used to investigate the quality of sleep among HD patients in two cities in Saudi Arabia.

Structural variation, magnetism and single-source deposition of lanthanide-containing polyoxotitanates.

Heterometal-containing polyoxotitanates (POTs) are much-studied single-source precursors (SSPs) for doped TiO. In this work the properties of a wide range of lanthanide-containing POTs are studied to assess their potential use as SSPs for Ln-Ti hybrid oxides. The novel cage compounds [{TiO(OEt)}(EtOH·LnCl)] (Ln = Sm, Gd, Tb, Dy, Ho, Tm and Yb) are structurally characterised.

Health Information on Pre-Exposure Prophylaxis From Search Engines and Twitter: Readability Analysis.

Background: Pre-exposure prophylaxis (PrEP) is proven to prevent HIV infection. However, PrEP uptake to date has been limited and inequitable. Analyzing the readability of existing PrEP-related information is important to understand the potential impact of available PrEP information on PrEP uptake and identify opportunities to improve PrEP-related education and communication.

Dermatological manifestations associated with COVID-19 and COVID-19 vaccination: results from the Lebanese COVID registry.

Background: A number of cutaneous manifestations and adverse cutaneous reactions have been associated with COVID-19 infection and vaccine.

Objectives: A Lebanese national registry was established to characterize the dermatologic manifestations and adverse cutaneous reactions associated with COVID-19 infection and vaccination in a sample of the Lebanese population.

Methods: An observational cross-sectional study was conducted via a web-based clinical form distributed to physicians wishing to report their cases from May 2021 till May 2022.

Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.

The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed knockin mice expressing human TREM2-R47H from one mutant mouse Trem2 allele. TREM2-R47H mice showed increased seizure activity in response to an acute excitotoxin challenge, compared to wildtype controls or knockin mice expressing the common variant of human TREM2.

Understanding the Surface Regeneration and Reactivity of Garnet Solid-State Electrolytes.

Garnet solid-electrolyte-based Li-metal batteries can be used in energy storage devices with high energy densities and thermal stability. However, the tendency of garnets to form lithium hydroxide and carbonate on the surface in an ambient atmosphere poses significant processing challenges. In this work, the decomposition of surface layers under various gas environments is studied by using two surface-sensitive techniques, near-ambient-pressure X-ray photoelectron spectroscopy and grazing incidence X-ray diffraction.

Monitoring and simulation of the fuel irradiation behavior in nuclear reactors based on phononic crystal structure.

We have presented in the current work a novel idea for simulating the irradiation behaviors of the nuclear fuel pellets in nuclear reactors by using a one-dimensional defective phononic crystal (1D-DPnC) design was presented. The transmission spectra of the incident mechanical waves were considered basic data for expressing the characteristics of different nuclear fuel-pellets. Herein, the density, sound speed, and Young's modulus of the fuel-pellets represent the key parameters that are influenced by the irradiation behaviors of these pallets.

Li iontronics in single-crystalline T-NbO thin films with vertical ionic transport channels.

The niobium oxide polymorph T-NbO has been extensively investigated in its bulk form especially for applications in fast-charging batteries and electrochemical (pseudo)capacitors. Its crystal structure, which has two-dimensional (2D) layers with very low steric hindrance, allows for fast Li-ion migration. However, since its discovery in 1941, the growth of single-crystalline thin films and its electronic applications have not yet been realized, probably due to its large orthorhombic unit cell along with the existence of many polymorphs.

Curiosity, Surprise, and the Recall of Tobacco-Related Health Information in Adolescents.

A key goal of health communications designed to prevent smoking initiation during adolescence is for the tobacco-related information to be retained in memory beyond immediate message exposure. Here, we test the role for epistemic emotions, specifically curiosity and surprise, in facilitating memory for tobacco-related health information. Participants ( = 294 never-smoking adolescents, ages 14-16 years) performed a trivia guessing task wherein they guessed the answers to general trivia and smoking-related trivia questions.

Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy.

Objective: Cesarean Section (CS) is associated with an increased risk of hemorrhage. Many drugs are used to decrease this risk. We aim to compare the combination of ethamsylate and tranexamic acid, oxytocin, and placebo in women undergoing CS.