Introduction: Sjögren's syndrome (SS) is a chronic autoimmune disorder primarily characterized by dysfunction of the exocrine glands, leading to dryness of the eyes and mouth (sicca symptoms). Labial salivary gland biopsy (LSGB) is a key diagnostic tool used to confirm SS through histopathological analysis. LSGB evaluates lymphocytic infiltration in the salivary glands, a hallmark of SS.
View Article and Find Full Text PDFIntroduction: Endometrial carcinoma, the most prevalent gynecologic malignancy in developed countries, represents a significant public health issue worldwide. DNA mismatch repair (dMMR) deficiency is an important molecular mechanism in endometrial carcinoma development, clinical course, and prognosis.
Aims And Objectives: This study aimed to determine the incidence and histological subtypes of endometrial carcinoma among Bahraini women, evaluate the prevalence of MMR deficiency using immunohistochemistry in these patients and analyze the association between MMR deficiency and clinicopathological features, including potential links to Lynch syndrome.
Breast cancer is the most common cancer among women and the leading cause of cancer-related deaths globally. Ductal carcinoma of no special type is the most prevalent, followed by lobular carcinoma. Finding a triple-negative breast cancer of intermediate grade on core biopsies should raise the possibility of dealing with one of the rare subtypes such as microglandular adenosis (MGA)-associated carcinoma.
View Article and Find Full Text PDFGastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the alimentary tract in adults. The most common site is the stomach, followed by the small intestine. The clinical presentation varies from an incidental finding in asymptomatic patients to a large palpable mass causing complications such as bowel obstruction or viscus perforation.
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