: A web-based application for in-depth exploration of multi-omics data with brightfield histology.

Spatial -OMICS technologies facilitate the interrogation of molecular profiles in the context of the underlying histopathology and tissue microenvironment. Paired analysis of histopathology and molecular data can provide pathologists with otherwise unobtainable insights into biological mechanisms. To connect the disparate molecular and histopathologic features into a single workspace, we developed (unctional nit tate dentificati in WSIs [Whole Slide Images]), a web-based tool that provides users with a broad array of visualization and analytical tools including deep learning-based algorithms for in-depth interrogation of spatial -OMICS datasets and their associated high-resolution histology images.

ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology.

Artificial intelligence (AI) has extensive applications in a wide range of disciplines including healthcare and clinical practice. Advances in high-resolution whole-slide brightfield microscopy allow for the digitization of histologically stained tissue sections, producing gigapixel-scale whole-slide images (WSI). The significant improvement in computing and revolution of deep neural network (DNN)-based AI technologies over the last decade allow us to integrate massively parallelized computational power, cutting-edge AI algorithms, and big data storage, management, and processing.

ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology.

Artificial intelligence (AI) has extensive applications in a wide range of disciplines including healthcare and clinical practice. Advances in high-resolution whole-slide brightfield microscopy allow for the digitization of histologically stained tissue sections, producing gigapixel-scale whole-slide images (WSI). The significant improvement in computing and revolution of deep neural network (DNN)-based AI technologies over the last decade allow us to integrate massively parallelized computational power, cutting-edge AI algorithms, and big data storage, management, and processing.

Connecting intercity mobility with urban welfare.

While significant effort has been devoted to understand the role of intraurban characteristics on sustainability and growth, much remains to be understood about the effect of interurban interactions and the role cities have in determining each other's urban welfare. Here we consider a global mobility network of population flows between cities as a proxy for the communication between these regions, and analyze how it correlates with socioeconomic indicators. We use several measures of centrality to rank cities according to their importance in the mobility network, finding PageRank to be the most effective measure for reflecting these prosperity indicators.

Growing urban bicycle networks.

Cycling is a promising solution to unsustainable urban transport systems. However, prevailing bicycle network development follows a slow and piecewise process, without taking into account the structural complexity of transportation networks. Here we explore systematically the topological limitations of urban bicycle network development.

A sampling-guided unsupervised learning method to capture percolation in complex networks.

The use of machine learning methods in classical and quantum systems has led to novel techniques to classify ordered and disordered phases, as well as uncover transition points in critical phenomena. Efforts to extend these methods to dynamical processes in complex networks is a field of active research. Network-percolation, a measure of resilience and robustness to structural failures, as well as a proxy for spreading processes, has numerous applications in social, technological, and infrastructural systems.

Impact of urban structure on infectious disease spreading.

The ongoing SARS-CoV-2 pandemic has been holding the world hostage for several years now. Mobility is key to viral spreading and its restriction is the main non-pharmaceutical interventions to fight the virus expansion. Previous works have shown a connection between the structural organization of cities and the movement patterns of their residents.

Turing patterns mediated by network topology in homogeneous active systems.

Mechanisms of pattern formation-of which the Turing instability is an archetype-constitute an important class of dynamical processes occurring in biological, ecological, and chemical systems. Recently, it has been shown that the Turing instability can induce pattern formation in discrete media such as complex networks, opening up the intriguing possibility of exploring it as a generative mechanism in a plethora of socioeconomic contexts. Yet much remains to be understood in terms of the precise connection between network topology and its role in inducing the patterns.