Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial.

Background: Cardiotoxicity is a concern for cancer survivors undergoing anthracycline chemotherapy. Enalapril has been explored for its potential to mitigate cardiotoxicity in cancer patients. The dose-dependent cardiotoxicity effects of anthracyclines can be detected early through the biomarker cardiac troponin.

Genomic insights into : a review of progress in the genomics era.

Genomics has emerged as a great tool in enhancing our understanding of the biology of Verticillium species and their interactions with the host plants. Through different genomic approaches, researchers have gained insights into genes, pathways and virulence factors that play crucial roles in both Verticillium pathogenesis and the defense responses of their host organisms. This review emphasizes the significance of genomics in uncovering the mechanisms that underlie pathogenicity, virulence, and host resistance in Verticillium fungi.

The Global Road Traffic Death Rate and Human Development Index from 2000 to 2019: A Trend Analysis.

Background: Numerous studies on the association between the human development index (HDI) and road traffic death rate (RTDR) merely focus on developed countries, not reflecting the relationship between the HDI components and RTDR in a time-trend analysis. Accordingly, this study analyzes the trends of RTDR and their association with the HDI and its components from 2000 to 2019.

Methods: The RTDR data of 154 countries were imported into the unconditional latent growth model (LGM) to assess the RTDR trends.

Factors contributing to the burnout of the faculties of a medical university in Iran: A cross-sectional study.

Background And Aims: Faculty members confront a variety of obstacles over time, the most recent of which is the coronavirus disease 2019 pandemic, which may increase their vulnerability to burnout (BO). This study aims to examine BO in medical school faculties, as well as the factors that lead to BO and well-being in them.

Methods: This cross-sectional study was conducted in 2021 using online questionnaires completed by 222 faculty members of a medical university in Iran.

Emotional intelligence and happiness in clinical medical students: A cross-sectional multicenter study.

Background And Aims: Emotional intelligence (EI) has improved job performance and has been associated with the success of individuals. The interfering role of happiness in this equation is unneglectable; however, this association has not been established in clinical medical students exposed to work pressures and stressful hospital atmospheric. The present perusal was conducted to evaluate the relationship between EI and happiness in clinical medical students.

Rhizobacterial inoculation to improve the responses of olive cultivars to drought stress.

Tunisia is known as an underprivileged country in water resources, and water scarcity is evident in certain regions. In the long term, this situation could become more exacerbated, considering the increased risk of aridity. In this context, this work was carried out to study and compare the ecophysiological behavior of five olive cultivars facing drought stress and to evaluate the contribution of rhizobacteria to mitigate the effects of drought stress on these cultivars.

Effects of on hepatic and renal extracellular compounds turnover under diabetes in rat.

Hepatic and renal extracellular matrix (ECM) turnover associated with diabetes and potential beneficial effects of yellow lupin extract (YLE) need further investigations. The aim of this study was to explore the effect of yellow extract (YLE) on renal and hepatic ECM under diabetes. Composition of YLE performed by LC-ESI-MS.

Risk Factors Affecting 90-day Readmission of Patients with Inflammatory Bowel Disease.

: The rate of hospital readmission is seen as a measure of quality and accountability. Knowing the risk factors that can be changed could reduce the cost burden on patients with inflammatory bowel disease (IBD) and the health system. : Retrospective analysis was performed on the data extracted from hospital records during a 4-year period.

Resilient Nurses in the COVID-19 Compared With Non-COVID-19 Wards.

Introduction: Owing to daily exposure to high job stress, nurses need to use coping techniques. One of the coping strategies helping a person to cope with stressful situations effectively is resiliency skills. The aim of this cross-sectional study was to examine the factors related to nurses' resiliency during the coronavirus disease 2019 (COVID-19) epidemic.

Estimating willingness to pay for diabetes complications.

Background: Maximum willingness to pay (WTP) for a health benefit is connected to perceived value. This two-center study aims to analyse diabetic patients' WTP for obtaining a specific preventive treatment package to reduce severe diabetic complications and determine the factors that impact this value.

Methods: This cross-sectional research included 557 diabetics from two cities in Iran.

Genome-Based Analysis of Polyketide Synthase Gene Clusters.

Polyketides are structurally diverse and physiologically active secondary metabolites produced by many organisms, including fungi. The biosynthesis of polyketides from acyl-CoA thioesters is catalyzed by polyketide synthases, PKSs. Polyketides play roles including in cell protection against oxidative stress, non-constitutive (toxic) roles in cell membranes, and promoting the survival of the host organisms.

Preserving natural teeth versus extracting them: a willingness to pay analysis.

Background: Maximum willingness to pay (WTP) for a health benefit is related to perceived value. The goal of this study was to find out how much Iranian healthy people would be willing to pay to keep their natural teeth instead of having them pulled. This was done separately for the anterior and posterior teeth.

Impact of Octreotide on Early Complications After Liver Transplant: A Randomized, Double-Blind Placebo-Controlled Trial.

Objectives: Acute kidney injury and early allograft dysfunction are 2 common complications after liver transplant. Octreotide, through its various mechanisms, may have a role in preventing these complications.

Materials And Methods: In this randomized, double- blind placebo-controlled clinical trial, we randomly assigned 50 patients who underwent deceased donor liver transplant and fulfilled the study inclusion requirements to receive either octreotide infusion for 3 days in the first 3 days after transplant in the intensive care unit or placebo.

Burnout in hospital staff using partial least squares path modeling for job-person fit: The case of a tertiary referral hospital in southwest Iran.

Recent studies on burnout (BO) have included both individual and situational factors, referred to as job-person fit (JPF). The present study aimed to evaluate the prevalence rate of BO in the hospital staff working at a tertiary referral hospital in southwest Iran and then to highlight the importance of the person in the context of his/her work life. This cross-sectional study was conducted in 2020 on all hospital staff using a three-part questionnaire comprised of personal and work-situational factors, the Perceived Stress Scale (PSS), and the Psychological Empowerment Scale (PES).

Colectomy in Ulcerative Colitis: Trends in Southern Iran in a Decade.

Background: Colectomy is considered as a part of therapeutic armamentarium in ulcerative colitis. The availability of new biologic treatments might have affected the trend of using this modality.

Methods: The hospital records of all tertiary centers in Shiraz, which are the main centers for the treatment of ulcerative colitis (UC) in southern Iran, were reviewed to estimate the total number of admissions for the treatment of severe UC and colectomy among patients from 2009 to 2019.

Rapid PCR-based method for herbivore dietary evaluation using plant-specific primers.

Polyphagous pests cause significant economic loss worldwide through feeding damage on various cash crops. However, their diets in agricultural landscapes remain largely unexplored. Pest dietary evaluation in agricultural fields is a challenging task currently approached through visual observation of plant feeding and microscopic identification of semi-digested plant material in pest's guts.

NOXA Is Important for 's Penetration Ability and Virulence.

NADPH oxidase (Nox) genes are responsible for Reactive Oxygen Species (ROS) production in living organisms such as plants, animals, and fungi, where ROS exert different functions. ROS are critical for sexual development and cellular differentiation in fungi. In previous publications, two genes encoding thioredoxin and NADH-ubiquinone oxidoreductase involved in maintaining ROS balance were shown to be remarkably induced in a highly versus a weakly aggressive isolate.

Role of Exopolygalacturonase-Related Genes in Potato- Interaction.

is a hemibiotrophic pathogen responsible for great losses in dicot crop production. An gene (VDAG_03463,) identified using subtractive hybridization/cDNA-AFLP, showed higher expression levels in highly aggressive than in weakly aggressive isolates. We used a vector-free split-marker recombination method with PEG-mediated protoplast to delete the gene in This is the first instance of using this method for transformation.

Gene Expression of Putative Pathogenicity-Related Genes in in Response to Elicitation with Potato Extracts and during Infection Using Quantitative Real-Time PCR.

Quantitative real-time PCR was used to monitor the expression of 15 's genes, putatively involved in pathogenicity, highly (HAV) and weakly aggressive (WAV) isolates after either (i) elicitation with potato leaf, stem, or root extracts, or (ii) inoculation of potato detached petioles. These genes, i.e.

Social, economic, and legislative factors and global road traffic fatalities.

Background: Road traffic fatalities (RTF) is the 8th cause of mortality around the world. At the end of the Decade of Action, it would be of utmost importance to revisit our knowledge on the determinants of RTF. The aim of this study is to assess factors related to RTF at global level.

Draft genome sequences of five species from plantations in China, , and .

Draft genome sequences of five species [including , , , and ], , and are presented. Species of are the causal agents of Eucalyptus leaf blight disease, threatening the growth and sustainability of plantations in China. is the causal agent of stem canker in native and exotic in South Africa.

Agrobacterium-mediated transformation of Ceratocystis albifundus.

Functional association between genomic loci and specific biological traits remains lacking in many fungi, including the African tree pathogen Ceratocystis albifundus. This is mainly because of the absence of suitable transformation systems for allowing genetic manipulation of this and other fungi. Here, we present an optimized protocol for Agrobacterium tumefaciens-mediated transformation of C.

Distribution and Evolution of Nonribosomal Peptide Synthetase Gene Clusters in the .

In filamentous fungi, genes in secondary metabolite biosynthetic pathways are generally clustered. In the case of those pathways involved in nonribosomal peptide production, a nonribosomal peptide synthetase (NRPS) gene is commonly found as a main element of the cluster. Large multifunctional enzymes are encoded by members of this gene family that produce a broad spectrum of bioactive compounds.